PDF(Pubmed)
Abstract：
OBJECTIVE: Inflammatory myofibroblastic tumors (IMTs) are rare, solid, potentially malignant lesions of uncertain etiology. Histologically, IMTs exhibit a combination of lymphocytes and inflammatory cells within a fibroblastic myxoid layer. The diagnosis of IMTs poses a challenge for various medical specialties, including surgeons, pathologists, and oncologists, due to their non-specific clinical presentation. Furthermore, radiologists face difficulties in interpreting computed tomography (CT) or magnetic resonance imaging (MRI) results, which often yield polymorphic and inconclusive findings. Ultimately, histopathologists play a crucial role in reaching a definitive diagnosis based on the tumor\'s histological characteristics. They are detected in every system of the human body, most commonly in the lungs. Here, we report an uncommon occurrence of IMT in the spleen of a patient with nonspecific abdominal pain.
METHODS: A 56-year-old Caucasian female presented to Konstantopouleio General Hospital of Nea Ionia, Athens, Greece, with abdominal pain and discomfort. The patient had no significant medical history and normal laboratory tests. An abdominal CT revealed a large mass in the spleen. A splenectomy was performed. Histopathological analysis of the tumor revealed IMTS.
CONCLUSIONS: Splenic IMT is a rare benign tumor with moderate malignant potential. It lacks a distinct clinical presentation and is typically identified either incidentally or during the examination of abdominal pain.
METHODS: A 56-year-old Caucasian female presented to Konstantopouleio General Hospital of Nea Ionia, Athens, Greece, with abdominal pain and discomfort. The patient had no significant medical history and normal laboratory tests. An abdominal CT revealed a large mass in the spleen. A splenectomy was performed. Histopathological analysis of the tumor revealed IMTS.
CONCLUSIONS: Splenic IMT is a rare benign tumor with moderate malignant potential. It lacks a distinct clinical presentation and is typically identified either incidentally or during the examination of abdominal pain.
摘要：
目的：炎性肌纤维母细胞瘤（IMT）是罕见的，固体,病因不明的潜在恶性病变。组织学上,IMT在成纤维细胞粘液样层内表现出淋巴细胞和炎性细胞的组合。IMT的诊断对各种医学专业提出了挑战，包括外科医生,病理学家,和肿瘤学家，由于他们的非特异性临床表现。此外，放射科医生在解释计算机断层扫描（CT）或磁共振成像（MRI）结果方面面临困难，通常会产生多态性和不确定的发现。最终,组织病理学家在根据肿瘤的组织学特征做出明确诊断方面起着至关重要的作用。它们在人体的每个系统中都被检测到，最常见的是肺部。这里,我们报道了1例非特异性腹痛患者脾脏IMT的罕见发生.
方法：一名56岁的白种人女性被送到NeaIonia的Konstantopouleio总医院，雅典,希腊,腹痛和不适。患者没有明显的病史和正常的实验室检查。腹部CT显示脾脏有大量肿块。进行了脾切除术。肿瘤的组织病理学分析显示IMTS。
结论：脾IMT是一种具有中度恶性潜能的罕见良性肿瘤。它缺乏独特的临床表现，通常是偶然或在腹痛检查期间发现的。
方法：一名56岁的白种人女性被送到NeaIonia的Konstantopouleio总医院，雅典,希腊,腹痛和不适。患者没有明显的病史和正常的实验室检查。腹部CT显示脾脏有大量肿块。进行了脾切除术。肿瘤的组织病理学分析显示IMTS。
结论：脾IMT是一种具有中度恶性潜能的罕见良性肿瘤。它缺乏独特的临床表现，通常是偶然或在腹痛检查期间发现的。
