目的:本报告的目的是审查口腔FLH,重点是腭部病变。
方法:在PubMed上进行了全面搜索,以获取在英语文献中发表的病例报告和病例系列FLH。从整理的文章中寻找相关数据,包括病人的人口统计,临床表现,成像方式和发现,合并症,病因,遗产管理,和病变的结果。还提供了一个新的pa病例来说明该病变的几个特征。
结果:总计,收集32例病例以建立临床病理相关性,代表已发布案例的最大集合。大多数受影响的患者至少60岁,并且具有决定性的女性偏爱。大部分病灶≤3cm,表现为正常颜色,紫红色或红色,从软到硬。值得注意的是,32%的腭部FLH与义齿磨损相关,16%的病例记录病灶复发。迄今为止,报告的腭部FLH病例均未发生恶变。
结论:腭部FLH常作为反应性过程出现。关键的组织病理学和组织化学评估对于建立良性是必要的。术后,临床医生应跟踪患者至少5年的复发,并对肿瘤改变保持警惕,因为一些已发表的非口腔FLHs已发生恶性转化,通常是淋巴瘤。
OBJECTIVE: The aim of this report was to review oral follicular lymphoid hyperplasia, with emphasis on palatal lesions.
METHODS: A comprehensive search was performed on PubMed for case reports and case series of palatal follicular lymphoid hyperplasia published in the English language literature. Relevant data from collated articles was sought, including patient demographics, clinical manifestations, imaging modalities and findings, comorbidities, etiopathogenesis, lesional management, and lesional outcome. A new palatal case has also been provided to illustrate several features of this lesion.
RESULTS: In total, 32 cases were assembled to establish clinicopathologic correlations, representing the largest aggregation of published cases. Most of the affected patients were at least 60 years old and with a decisive female predilection. The majority of lesions were ≤ 3 cm, appearing as normal color, purple-red or red, and varied from soft to firm. Notably, 32% of palatal follicular lymphoid hyperplasias were associated with denture wear, and lesional recurrence was recorded in 16% of cases. To date, none of the reported cases of palatal follicular lymphoid hyperplasia has undergone malignant transformation.
CONCLUSIONS: Palatal follicular lymphoid hyperplasias often arise as a reactive process. Critical histopathologic and histochemical assessments are necessary to establish benignity. Postoperatively, clinicians should follow patients for at least 5 years for recurrence and remain vigilant for neoplastic change as several published accounts of non-oral follicular lymphoid hyperplasias have undergone malignant transformation, usually to lymphoma.