PDF(Pubmed)
Abstract：
Cutaneous reactive lymphoid proliferation (CRLP) is a condition that resembles cutaneous lymphoma, and differentiating the two is necessary for proper diagnosis and treatment. It can be idiopathic or caused by viruses, drugs, or skin trauma, resulting in reactive lymphoid hyperplasia. Several clinical and histopathological features are helpful for differentiating CRLP from lymphoma, and they must be considered as a whole to reach the correct diagnosis. The number, location, and progression of CRLP lesions are important clinical clues, while the type, size, arrangement, surface markers, and clonality of the cellular infiltrate are key histopathological clues. We present a case in which CRLP arose in the setting of concomitant antidepressant and antihypertensive use, which are both potential causes of CRLP. In this case, excision served as both diagnosis and treatment. The benign presentation and lack of clonality led to the diagnosis of CRLP. While the cause is unknown, drug exposure was a possible inciting factor, and the patient will be monitored for recurrence.
摘要：
皮肤反应性淋巴增生（CRLP）是一种类似于皮肤淋巴瘤的疾病，区分两者对于正确的诊断和治疗是必要的。它可以是特发性的或由病毒引起的，毒品,或者皮肤创伤,导致反应性淋巴增生。一些临床和组织病理学特征有助于区分CRLP和淋巴瘤。必须将它们作为一个整体来考虑，以达到正确的诊断。数字,location,CRLP病变的进展是重要的临床线索，而类型,尺寸,安排,表面标记,细胞浸润的克隆性是关键的组织病理学线索。我们提出了一个案例，其中CRLP在伴随抗抑郁和抗高血压使用的情况下出现，都是CRLP的潜在原因。在这种情况下,切除既是诊断又是治疗。良性表现和缺乏克隆性导致CRLP的诊断。虽然原因不明，药物暴露是一个可能的煽动因素，将监测患者的复发情况。
