皮肤假性淋巴瘤(C-PSL)被定义为主要由B细胞或T细胞组成的反应性多克隆良性淋巴增生过程。本地化或传播。它在停止致病因素(例如药物)后或在非积极治疗后自发愈合。作者在此介绍了一个C-PSL的病例,并进行了免疫组织化学研究。一位78岁的男性因手臂皮肤轻微瘙痒肿胀而咨询了我们医院。他否认昆虫咬伤和外伤。他通常摄入的药物是高血压药物,高脂血症,糖尿病,和情绪障碍。体格检查显示am轻度糜烂性肿胀。病变测量为1x1x0.2cm。对病变进行了活检,它显示了小淋巴细胞的过度增殖。淋巴样细胞缺乏明显的非典型特征并且出现成熟。带有核仁的淋巴母细胞散布。在下真皮中也看到结节结构。免疫组织化学,淋巴样细胞的波形蛋白呈阳性,CD3、CD4、CD5、CD8、CD10、CD15、CD20、CD23、CD30、CD43、CD38、CD138、CD45RO、CD79α,Bcl-2,Bcl-6,κ链,λ链,和Ki-67(标记指数=7%)。没有观察到轻链限制。淋巴细胞CD15和CD30呈阳性标记。可见大量CD38、CK79α和CD138阳性的浆细胞。细胞角蛋白(CK)CAM5.2,CKAE1/3,CK34BE12,CK5/6,CK7,CK8,CK18,CK19,CK20,EMA,CEA,CD56,CD57,p53,KIT,PDGFRA,和细胞周期蛋白D1。因为组成细胞都是B细胞,包括浆细胞和T细胞,没有看到轻链限制,没有看到组织学上的异型,诊断为皮肤假性淋巴瘤。低Ki-67标记和p53阴性也提示诊断。病变的大小略有缩小(从1厘米到0.7厘米),活检后11个月的病原体仍然未知.
Cutaneous
pseudolymphoma (C-PSL) is defined as reactive polyclonal benign lymphoproliferative process predominantly composed of either B-cells or T-cells, localized or disseminated. It heals spontaneously after cessation of the causative factor (e.g. drugs) or after non-aggressive treatment. The author herein presents a case of C-PSL with an immunohistochemical
study. A 78-year-old man consulted our hospital because of slightly itching skin swelling on the arm. He denied insect bite and traumatic injury. His usual intake drugs were drugs of hypertension, hyperlipidemia, diabetes mellitus, and emotional disorders. Physical examination showed mildly erosive swelling of the am. The lesion measured 1 x 1 x 0.2 cm. Biopsy of the lesion was taken, and it revealed excessive proliferation of small lymphoid cells. The lymphoid cells lacked apparent atypical features and appeared matures. Lymphoblastic cells with nucleoli were scattered. Nodular structures were also seen in the lower dermis. Immunohistochemically, the lymphoid cells were positive for vimentin, CD3, CD4, CD5, CD8, CD10, CD15, CD20, CD23, CD30, CD43, CD38, CD138, CD45RO, CD79α, bcl-2, bcl-6, κ-chain, λ-chain, and Ki-67 (labeling index=7%). No light chain restriction is seen. The lymphoblastic cells were positively labeled for CD15 and CD30. Plasma cells positive for CD38, CK79α and CD138 were seen in a significant amounts. They were negative for cytokeratin (CK) CAM5.2, CKAE1/3, CK34BE12, CK5/6, CK7, CK8, CK18, CK19, CK20, EMA, CEA, CD56, CD57, p53, KIT, PDGFRA, and cyclin D1. Because the constituent cells were both B-cells including plasm cells and T-cells, no light-chain restriction was seen, and no histological atypia was seen, a diagnosis of cutaneous
pseudolymphoma was made. The low Ki-67 labeling and negative p53 also suggested the diagnosis. The lesion slightly reduced in size (from 1 cm to 0.7 cm), the causative agent was still unknown 11 months after the biopsy.