背景:假淋巴瘤是一种罕见的,良性,形成以非肿瘤性淋巴细胞增殖为特征的团块样病变的非特异性病症。缺乏特定的临床症状,血清学标记,和成像功能,诊断是困难的。我们报告了5例肝假性淋巴瘤,并对现有文献进行了系统回顾,以提高我们对这种罕见肝病的认识。
方法:随访2002年1月至2022年1月华西医院5例肝假性淋巴瘤。我们还通过PubMed数据库总结了1981年1月至2021年12月的肝假性淋巴瘤病例,并全面分析了病例特征。
结果:5例病理特征为良性淋巴组织增生,淋巴滤泡形成,和两极分化的生发中心。免疫组织化学,原位杂交,基因重排显示非恶性淋巴瘤。此外,从1981年到2021年,PubMed数据库共报告了116例病例.肝假性淋巴瘤在中年和老年妇女中的发病率较高,并且在亚洲有更多的报道。所有病例均经病理诊断,其中85.95%的患者接受手术治疗。
结论:肝假性淋巴瘤是一种极为罕见的良性疾病,主要是中老年妇女。没有独特的临床和影像学特征,病理诊断是目前可靠性高的方法。因此,在中老年妇女中没有原发性肝肿瘤或转移性肿瘤的危险因素的情况下,应考虑假性淋巴瘤的可能性,以避免广泛的治疗。
BACKGROUND: Pseudolymphoma is a rare, benign, nonspecific condition that forms a mass-like lesion characterized by the proliferation of non-neoplastic lymphocytes. Lacking of specific clinical symptoms, serological markers, and imaging features, the diagnosis is difficult. We reporte five cases of hepatic
pseudolymphoma and provide a systematic review of existing literatures to improve our understanding of this rare liver disease.
METHODS: We followed-up five cases of hepatic
pseudolymphoma in West
China Hospital from January 2002 to January 2022. We also summarized the cases of hepatic
pseudolymphoma from January 1981 to December 2021 through the PubMed database and comprehensively analyzed the characteristics of the cases.
RESULTS: The pathologic features of the five cases were characterized by benign lymphoid tissue hyperplasia, lymphoid follicle formation, and a polarized germinal center. Immunohistochemistry, in situ hybridization, and gene rearrangement revealed non-malignant lymphoma. Besides, a total of 116 cases have been reported in the PubMed database from 1981 to 2021. The incidence of hepatic
pseudolymphoma is higher in middle-aged and elderly women and has been reported more frequently in Asia. All cases were pathologically diagnosed, among which 85.95% of the patients were treated by surgery.
CONCLUSIONS: Hepatic pseudolymphoma is an extremely rare benign disease, mainly in middle-aged and elderly women. Without distinctive clinical and imaging characteristics, pathological diagnosis is the highly reliable method at present. Thus, in the absence of risk factors for a primary liver tumor or metastatic tumor in middle-aged and elderly women, the possibility of pseudolymphoma should be considered to avoid extensive treatments.