目的:探讨富血小板血浆(PRP)和富血小板纤维蛋白(PRF)在耳鼻咽喉科不同专科的应用及疗效。
方法:使用Cochrane中央对照试验注册进行了系统搜索,PubMed,EMBASE,Medline,Clinicaltrials.gov,Scopus,和谷歌学者截至2024年3月。具有原始数据的英语随机对照试验评估PRP和PRF在与耳鼻喉科亚专科相关的各种手术和非手术过程中的使用。数据集仅限于随机对照试验(RCTs),以具有最佳的证据质量和可能的建议。
结果:我们的数据库搜索产生了591份手稿。审查标题和摘要后,主要排除了四百二十六项研究。其余165篇文章进行了完整的研究,51篇文章符合纳入标准。所有研究均为RCT,日期为2001年至2024年。他们包括19项与耳科学有关的研究,与鼻学有关的10项研究,与面部整形手术有关的7项研究,6项与头颈部手术相关的研究,3项与普通耳鼻咽喉科相关的研究,3项与儿科有关的研究,2项与喉科有关的研究,和1项与睡眠医学有关的研究。
结论:PRP和PRF是安全的,易于使用,以及多种耳鼻咽喉科病理的潜在有效治疗选择。作为一种自体材料,没有免疫反应的风险,因此已被许多耳鼻喉科医师选择为可行的治疗选择。更大的研究将有助于确认功效并允许针对该治疗选择的优化患者选择。
OBJECTIVE: To explore utilization and efficacy of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in different sub-specialties of otolaryngology.
METHODS: A systematic search was performed using Cochrane Central Register of Controlled Trials, PubMed, EMBASE, Medline, Clinicaltrials.gov, Scopus, and Google Scholar up to March 2024. English language randomized controlled trials with original data evaluating the use of PRP and PRF in various surgical and non-surgical procedures related to otolaryngologic sub-specialties. Dataset was limited to randomized controlled trials (RCTs) to have the best quality of evidence and possible recommendation.
RESULTS: Our database search resulted in 591 manuscripts. Four hundred twenty-six studies were primarily excluded after reviewing the title and abstract. The remaining 165 articles were studied completely, and 51 articles met the inclusion criteria. All the studies were RCTs and dated from 2001 to 2024. They included 19 studies related to otology, 10 studies related to rhinology, 7 studies related to facial plastic surgery, 6 studies related to head and neck surgery, 3 studies related to general otolaryngology, 3 studies related to pediatrics, 2 studies related to laryngology, and 1 study related to sleep medicine.
CONCLUSIONS: PRP and PRF are safe, easy to use, and potentially effective treatment options for multiple otolaryngology pathologies. As an autologous material, there is no risk of immune reaction, and thus has been selected as a viable treatment option by many otolaryngologists. Larger studies would be helpful to confirm efficacy and allow for optimized patient selection for this treatment option.