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Abstract：
Background. Medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis (ORN) are associated with severe disability and continuous pain, both of which are very difficult to control. This study aims to evaluate the outcome of platelet-rich fibrin (PRF) treatment compared to iodoform gauze packing and the primary suture of oral mucosa in patients with both MRONJ and ORN. Methods. Patients suffering from MRONJ and ORN who were treated in the Oral and Maxillofacial Surgery Clinic of Cluj-Napoca in the last 10 years were selected for this study from the hospital database. Results. PRF treatment proved to be a reliable method to help heal the necrotic bone sites. High-ASA risk patients and immunosuppressed patients are more prone to recurrence and persistent signs and symptoms. Intravenous bisphosphonates produce more intense symptomatology compared to oral administration. The posterior mandible is more difficult to treat compared to other sites. Conclusions. The quality of life of MRONJ and ORN patients may be improved by a protocol that reduces pain and hospitalization.
摘要：
背景。药物相关的颌骨坏死（MRONJ）和放射性骨坏死（ORN）与严重的残疾和持续的疼痛有关，两者都很难控制。这项研究旨在评估MRONJ和ORN患者与碘仿纱布填塞和口腔粘膜初级缝合相比，富血小板纤维蛋白（PRF）治疗的结果。方法。从医院数据库中选择了最近10年在Cluj-Napoca口腔颌面外科诊所接受治疗的MRONJ和ORN患者进行这项研究。结果。PRF治疗被证明是帮助坏死骨部位愈合的可靠方法。ASA高危患者和免疫抑制患者更容易复发和持续的体征和症状。与口服施用相比,静脉内双膦酸盐产生更强烈的症状学。与其他部位相比，后下颌骨更难治疗。Conclusions.MRONJ和ORN患者的生活质量可以通过减少疼痛和住院的方案来改善。
