■研究氧化平衡评分(OBS)与子宫内膜异位症之间的关系。
■这项横断面研究使用了国家健康和营养检查调查(NHANES)的四个周期(1999-2000年,2001-2002年,2003-2004年和2005-2006年)。OBS涉及16种膳食营养素和4种生活方式因素,包括5种前氧化剂和15种抗氧化剂。根据加权四分位数,OBS分为四类:<12.54、12.54-18.70、18.71-24.68和>24.68。根据生殖健康问卷的问题诊断子宫内膜异位症。采用加权多因素Logistic分析探讨OBS与子宫内膜异位症的相关性。根据月经规律和女性激素使用情况进行亚组分析。
■共包括5095名妇女,1140(22.37%),1232(24.18%),1224(24.02%),OBS<12.54,12.54-18.70,18.71-24.68和>24.68类别中的1499名(29.42%)女性,分别。调整年龄后,种族,家庭贫困收入比(PIR),教育水平,子宫肌瘤,月经规律,卵巢切除术,使用女性荷尔蒙,高血压,血脂异常,和类固醇药物,与低OBS(<12.54)相比,高OBS(>24.68)与子宫内膜异位症的几率较低相关[优势比(OR)=0.70,95%置信区间(CI):0.50-0.97,P=0.033].在月经不调(OR=0.58,95%CI:0.37-0.91,P=0.020)和使用女性激素(OR=0.71,95%CI:0.52-0.98,P=0.037)的女性中也发现了类似的结果。
■高OBS与子宫内膜异位症的几率较低有关,尤其是月经不调和女性荷尔蒙使用的女性。
UNASSIGNED: To investigate the association between the oxidative balance score (OBS) and endometriosis.
UNASSIGNED: This cross-sectional study used four cycles of the National Health and Nutrition Examination Survey (NHANES) (1999-2000, 2001-2002, 2003-2004, and 2005-2006). OBS involved 16 dietary nutrients and 4 lifestyle factors, including 5 pro-oxidants and 15 anti-oxidants. According to weighted quartiles, the OBS was divided into four categories: < 12.54, 12.54-18.70, 18.71-24.68, and > 24.68. Endometriosis was diagnosed based on a question from the reproductive health questionnaire. Weighted multivariate logistic analysis was used to investigate the association between OBS and endometriosis. Subgroup analysis was performed based on menstrual regularity and female hormone use.
UNASSIGNED: A total of 5095 women were included, with 1140 (22.37%), 1232 (24.18%), 1224 (24.02%), and 1499 (29.42%) women in the OBS < 12.54, of 12.54-18.70, of 18.71-24.68, and > 24.68 categories, respectively. After adjusting age, race, family poverty-to-income ratio (PIR), education level, uterine fibroids, menstrual regularity, oophorectomy, female hormone use, hypertension, dyslipidemia, and steroid drug, a high OBS (> 24.68) was found to be associated with lower odds of endometriosis [odds ratio (OR) = 0.70, 95% confidence interval (CI): 0.50-0.97, P = 0.033] compared to a low OBS (< 12.54). The similar result was also found in women with irregular menstruation (OR = 0.58, 95% CI: 0.37-0.91, P = 0.020) and with female hormone use (OR = 0.71, 95% CI: 0.52-0.98, P = 0.037).
UNASSIGNED: A high OBS was associated with lower odds of endometriosis, especially in women with irregular menstruation and female hormone use.