PDF(Pubmed)
Abstract：
BACKGROUND: No research report has been conducted to investigate the impact of oxidation balance score (OBS) on the estimated pulse wave velocity(ePWV).We aimed to examine the association between OBS and ePWV.
METHODS: We evaluated data for 13,073 patients from the National Health and Nutrition Examination Survey (NHANES). The exposure variable was OBS. The outcome variables was combination of ePWV and arterial stiffness.
RESULTS: We observed a significant negative correlation between OBS (Per 1SD increase) and ePWV in the gradually adjusted models. Based on the aforementioned results, a two-piecewise logistic regression adjusted model was subsequently employed to establish the association between OBS and elevated ePWV, and the inflection point was determined as 5. The increased risk of elevated ePWV (OR:0.70; 95%CI:0.51-0.94) gradually decreases with the increase of OBS on the left side of the inflection point; however, when OBS exceeds 5, this decrease in risk of elevated ePWV(OR:1.00; 95%CI:0.96-1.04) is no longer observed (P for log likelihood ratio test = 0.028).
CONCLUSIONS: There exists a significant association between OBS and ePWV in the context of American adults. Specifically, OBS exhibits a negative correlation with ePWV; however, when considering an elevated ePWV, a saturation effect is observed in relation to OBS.
METHODS: We evaluated data for 13,073 patients from the National Health and Nutrition Examination Survey (NHANES). The exposure variable was OBS. The outcome variables was combination of ePWV and arterial stiffness.
RESULTS: We observed a significant negative correlation between OBS (Per 1SD increase) and ePWV in the gradually adjusted models. Based on the aforementioned results, a two-piecewise logistic regression adjusted model was subsequently employed to establish the association between OBS and elevated ePWV, and the inflection point was determined as 5. The increased risk of elevated ePWV (OR:0.70; 95%CI:0.51-0.94) gradually decreases with the increase of OBS on the left side of the inflection point; however, when OBS exceeds 5, this decrease in risk of elevated ePWV(OR:1.00; 95%CI:0.96-1.04) is no longer observed (P for log likelihood ratio test = 0.028).
CONCLUSIONS: There exists a significant association between OBS and ePWV in the context of American adults. Specifically, OBS exhibits a negative correlation with ePWV; however, when considering an elevated ePWV, a saturation effect is observed in relation to OBS.
摘要：
背景：尚未进行任何研究报告来研究氧化平衡评分（OBS）对估计的脉搏波速度（ePWV）的影响。我们旨在研究OBS和ePWV之间的关联。
方法：我们评估了来自国家健康和营养调查（NHANES）的13,073名患者的数据。暴露变量为OBS。结果变量是ePWV和动脉僵硬度的组合。
结果：我们在逐渐调整的模型中观察到OBS（每1SD增加）与ePWV之间存在显着的负相关。根据上述结果,随后采用两分段逻辑回归调整模型来建立OBS与ePWV升高之间的关联，拐点确定为5。随着拐点左侧OBS的增加，ePWV升高的风险（OR：0.70;95CI：0.51-0.94）逐渐降低；然而，当OBS超过5时,将不再观察到ePWV升高风险的降低(OR:1.00;95CI:0.96~1.04)(对数似然比检验P=0.028).
结论：在美国成年人的背景下，OBS和ePWV之间存在显著关联。具体来说,OBS与ePWV呈负相关；然而，当考虑升高的PWV时，观察到与OBS有关的饱和效应。
方法：我们评估了来自国家健康和营养调查（NHANES）的13,073名患者的数据。暴露变量为OBS。结果变量是ePWV和动脉僵硬度的组合。
结果：我们在逐渐调整的模型中观察到OBS（每1SD增加）与ePWV之间存在显着的负相关。根据上述结果,随后采用两分段逻辑回归调整模型来建立OBS与ePWV升高之间的关联，拐点确定为5。随着拐点左侧OBS的增加，ePWV升高的风险（OR：0.70;95CI：0.51-0.94）逐渐降低；然而，当OBS超过5时,将不再观察到ePWV升高风险的降低(OR:1.00;95CI:0.96~1.04)(对数似然比检验P=0.028).
结论：在美国成年人的背景下，OBS和ePWV之间存在显著关联。具体来说,OBS与ePWV呈负相关；然而，当考虑升高的PWV时，观察到与OBS有关的饱和效应。
