■为了研究氧化平衡评分(OBS)、心血管死亡率(CVM),2型糖尿病(T2DM)患者的全因死亡率(ACM)。
■我们包括来自2005-2020年国家健康和营养检查调查(NHANES)的6,119名T2DM参与者。参与者的CVM和ACM状态一直持续到2019年12月31日。多变量Cox回归模型,卡普兰-迈耶曲线,对数秩检验,限制三次样条回归,和亚组分析,用于评估OBS之间的关系,CVM,和ACM。
■在100.9个月的中位随访期间,发生了1,790例ACM病例,其中508是由于心血管疾病。根据OBS的四分位数将T2DM参与者分为四组。第四季度的参与者往往更年轻,经济状况更好,已婚,受过高等教育,酒精消耗率较低,是不吸烟者,并表现出较低的ACM和CVM可能性。在多元Cox回归模型中,与Q4患者相比,Q1患者ACM风险增加30%(Q1,参考;Q4,HR:0.70,95CI:0.58~0.86),CVM风险增加43%(Q1,参考;Q4,HR:0.57,95CI:0.36~0.88).受限三次样条回归模型与OBS、CVM,和ACM。Kaplan-Meier生存曲线显示,Q4患者发生ACM和CVM的风险较低(log-rankP<0.05)。
■我们发现在T2DM患者中ACM和CVM随着OBS升高而增加。此外,OBS之间存在线性关系,ACM,和CVM。
UNASSIGNED: To investigate the association between oxidative balance score (OBS), cardiovascular mortality (CVM), and all-cause mortality (ACM) in type 2 diabetes mellitus (T2DM) patients.
UNASSIGNED: We included 6,119 participants with T2DM from the 2005-2020 National Health and Nutrition Examination Surveys (NHANES). The status of CVM and ACM of participants was followed through December 31, 2019. Multivariable Cox regression models, Kaplan-Meier curves, log-rank test, restricted cubic spline regression, and subgroup analysis, were used to evaluate the relationship between OBS, CVM, and ACM.
UNASSIGNED: During a median of 100.9 months follow-up, 1,790 ACM cases had occurred, 508 of which were due to cardiovascular disease. The T2DM participants were divided into four groups based on the quartiles of OBS. Participants with Q4 tended to be younger, financially better-off, married, highly educated, had lower alcohol consumption rates, were non-smokers, and exhibited a lower likelihood of ACM and CVM. In multivariate Cox regression models, compared with the patients with Q4, those with Q1 had a 30% increased risk for ACM (Q1, reference; Q4, HR: 0.70, 95%CI: 0.58-0.86) and a 43% increased risk for CVM (Q1, reference; Q4, HR: 0.57, 95%CI: 0.36-0.88). The restricted cubic spline regression models have no nonlinear relationship between OBS, CVM, and ACM. Kaplan-Meier survival curves showed that patients with Q4 had a lower risk of ACM and CVM (log-rank P < 0.05).
UNASSIGNED: We find that ACM and CVM increase with higher OBS in T2DM patients. Moreover, there are linear relationships between OBS, ACM, and CVM.