PDF(Pubmed)
Abstract：
UNASSIGNED: The oxidative balance score (OBS) is a comprehensive concept that includes 20 oxidative stressors and can be used to assess individual pro-oxidant versus antioxidant exposure, and the aim of the present study was to investigate the association between OBS and the risk of diabetic kidney disease (DKD), low estimated glomerular filtration rate (low-eGFR) and albuminuria in patients with diabetes mellitus (DM).
UNASSIGNED: This cross-sectional study included nationally representative consecutive National Health and Nutrition Examination Survey DM patients aged 18 years and older from 2003-2018. The continuous variable OBS was converted into categorical variables by quartiles, and weighted multiple logistic regression analyses and restricted triple spline models were used to explore the relationships. We also performed subgroup analyses and interaction tests to verify the stability of the results.
UNASSIGNED: A total of 5389 participants were included, representing 23.6 million non-institutionalized US residents. The results from both multivariate logistic regression analysis and restricted cubic spline models indicated that OBS and dietary OBS levels were negatively associated with the risk of DKD, low-eGFR, and albuminuria, without finding a significant correlation between lifestyle OBS and these clinical outcomes. Compared to the lowest OBS quartile group, the prevalence risk of DKD (OR = 0.61, 95% CI: 0.46-0.80), low-eGFR (OR = 0.46, 95% CI: 0.33-0.64) and albuminuria (OR = 0.68, 95% CI: 0.51-0.92) decreased by 39%, 54% and 32%, respectively, in the highest OBS quartile group. The results remained stable in subgroup analyses and no interaction between subgroups was found.
UNASSIGNED: Higher levels of OBS and dietary OBS were associated with a lower risk of DKD, low-eGFR, and albuminuria. These findings provided preliminary evidence for the importance of adhering to an antioxidant-rich diet and lifestyle among individuals with diabetes.
UNASSIGNED: This cross-sectional study included nationally representative consecutive National Health and Nutrition Examination Survey DM patients aged 18 years and older from 2003-2018. The continuous variable OBS was converted into categorical variables by quartiles, and weighted multiple logistic regression analyses and restricted triple spline models were used to explore the relationships. We also performed subgroup analyses and interaction tests to verify the stability of the results.
UNASSIGNED: A total of 5389 participants were included, representing 23.6 million non-institutionalized US residents. The results from both multivariate logistic regression analysis and restricted cubic spline models indicated that OBS and dietary OBS levels were negatively associated with the risk of DKD, low-eGFR, and albuminuria, without finding a significant correlation between lifestyle OBS and these clinical outcomes. Compared to the lowest OBS quartile group, the prevalence risk of DKD (OR = 0.61, 95% CI: 0.46-0.80), low-eGFR (OR = 0.46, 95% CI: 0.33-0.64) and albuminuria (OR = 0.68, 95% CI: 0.51-0.92) decreased by 39%, 54% and 32%, respectively, in the highest OBS quartile group. The results remained stable in subgroup analyses and no interaction between subgroups was found.
UNASSIGNED: Higher levels of OBS and dietary OBS were associated with a lower risk of DKD, low-eGFR, and albuminuria. These findings provided preliminary evidence for the importance of adhering to an antioxidant-rich diet and lifestyle among individuals with diabetes.
摘要：
■氧化平衡评分（OBS）是一个综合概念，包括20种氧化应激源，可用于评估个体的促氧化剂与抗氧化剂暴露，本研究的目的是调查OBS与糖尿病肾病（DKD）风险之间的关系，糖尿病（DM）患者的低估计肾小球滤过率（低eGFR）和白蛋白尿。
■这项横断面研究包括2003-2018年全国代表性的连续18岁及以上的DM患者。连续变量OBS按四分位数转换为分类变量，并使用加权多元逻辑回归分析和有限的三次样条模型来探索这些关系。我们还进行了亚组分析和相互作用测试，以验证结果的稳定性。
■共包括5389名参与者，代表2360万非制度化的美国居民。多变量logistic回归分析和有限三次样条模型的结果表明，OBS和膳食OBS水平与DKD的风险呈负相关。低eGFR，和蛋白尿，没有发现生活方式OBS与这些临床结果之间存在显着相关性。与最低的OBS四分位数组相比，DKD的患病率风险（OR=0.61，95%CI：0.46-0.80），低eGFR（OR=0.46，95％CI：0.33-0.64）和蛋白尿（OR=0.68，95％CI：0.51-0.92）降低了39％，54%和32%,分别,在最高的OBS四分位数组中。亚组分析结果保持稳定，未发现亚组之间的相互作用。
■较高水平的OBS和饮食OBS与较低的DKD风险相关，低eGFR，和蛋白尿。这些发现为糖尿病患者坚持富含抗氧化剂的饮食和生活方式的重要性提供了初步证据。
■这项横断面研究包括2003-2018年全国代表性的连续18岁及以上的DM患者。连续变量OBS按四分位数转换为分类变量，并使用加权多元逻辑回归分析和有限的三次样条模型来探索这些关系。我们还进行了亚组分析和相互作用测试，以验证结果的稳定性。
■共包括5389名参与者，代表2360万非制度化的美国居民。多变量logistic回归分析和有限三次样条模型的结果表明，OBS和膳食OBS水平与DKD的风险呈负相关。低eGFR，和蛋白尿，没有发现生活方式OBS与这些临床结果之间存在显着相关性。与最低的OBS四分位数组相比，DKD的患病率风险（OR=0.61，95%CI：0.46-0.80），低eGFR（OR=0.46，95％CI：0.33-0.64）和蛋白尿（OR=0.68，95％CI：0.51-0.92）降低了39％，54%和32%,分别,在最高的OBS四分位数组中。亚组分析结果保持稳定，未发现亚组之间的相互作用。
■较高水平的OBS和饮食OBS与较低的DKD风险相关，低eGFR，和蛋白尿。这些发现为糖尿病患者坚持富含抗氧化剂的饮食和生活方式的重要性提供了初步证据。
