目的:本研究旨在评估与早发性败血症(EOS)和晚发性败血症(LOS)相关的细菌感染的患病率和抗菌药物敏感性模式。
方法:这项描述性回顾性监测研究是对所有入住新生儿ICU的细菌性败血症新生儿进行的,从Tawam医院的无菌部位(脑脊液或血液)中分离出阳性培养物,AlAin,阿布扎比酋长国,阿联酋,从2012年1月到2021年12月。进行抗菌药物敏感性分析。
结果:与EOS(5.56%)相比,LOS(94.43%)的发生率更高。最流行的分离株(59.2%)是革兰氏阳性菌,革兰阴性菌占40.8%。主要分离株包括凝固酶阴性葡萄球菌(CONS,40.98%),克雷伯菌(16.04%),金黄色葡萄球菌(8.46%),大肠杆菌(8.24%),假单胞菌(7.57%),和B组链球菌(GBS,5.12%)。CONS在LOS病例中占主导地位(42.9%),而GBS是EOS病例的主要病原体(44%)。
结论:我们观察到CONS对氨苄西林的耐药水平降低,青霉素,克林霉素,红霉素,夫西地酸,庆大霉素,苯唑西林,利福平,和甲氧苄啶/磺胺。金黄色葡萄球菌对红霉素的耐药性增加,夫西地酸,庆大霉素,和左氧氟沙星,虽然大肠杆菌对头孢菌素的耐药性下降,庆大霉素,和甲氧苄啶/磺胺。根据经验,目前使用的抗生素似乎可以充分覆盖导致早期和晚期新生儿感染的最普遍的细菌。
OBJECTIVE: This study aims to assess the prevalence and antimicrobial susceptibility patterns of bacterial infections associated with both early-onset sepsis (EOS) and late-onset sepsis (LOS).
METHODS: This descriptive retrospective surveillance research was conducted on all neonates admitted to the neonatal ICU with bacterial sepsis, where positive cultures were isolated from sterile sites (either cerebrospinal fluid or blood) at Tawam Hospital, Al Ain, Emirate of Abu Dhabi, UAE, from January 2012 and December 2021. Antimicrobial susceptibility analysis was performed.
RESULTS: The incidence of LOS (94.43%) was higher compared to EOS (5.56%). The most prevalent isolates (59.2%) were gram-positive bacteria, with gram-negative bacteria accounting for 40.8%. The leading isolates included coagulase-negative Staphylococci (CONS, 40.98%), Klebsiella (16.04%), Staphylococcus aureus (8.46%), Escherichia coli (8.24%), Pseudomonas (7.57%), and Group B Streptococcus (GBS, 5.12%). CONS were predominant in LOS cases (42.9%), while GBS was the main pathogen in EOS cases (44%).
CONCLUSIONS: We observed reduced resistance levels of CONS against ampicillin, benzylpenicillin, clindamycin, erythromycin, fusidic acid, gentamicin, oxacillin, rifampicin, and trimethoprim/sulfa. S. aureus exhibited increased resistance to erythromycin, fusidic acid, gentamicin, and levofloxacin, while E. coli demonstrated decreased resistance against cephalothin, gentamicin, and trimethoprim/sulfa. The antibiotics currently employed empirically appear to provide adequate coverage against the most prevalent bacteria causing early- and late-onset neonatal infections.