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Abstract：
Burn is one of the leading causes of death and disability in children worldwide, and wound infection is an excellent challenge in burn treatment. We performed a retrospective review of pediatric burn patients with wound infections to reveal their clinical data and investigate pathogens\' distribution and drug resistance patterns to provide references for treatment. As a result, 330 pediatric burn patients with wound infections were identified; 65.8% (217/330) were < 2 years old. Most of the injuries were scalded and involved <10% total body surface area in size (TBSA), mainly causing II-degree burn and II + III-degree burn. Three hundred and fifty nine strains of pathogens were isolated, the primary pathogens were Staphylococcus aureus (45.4%) and Pseudomonas aeruginosa (18.7%). Both S. aureus and P. aeruginosa isolated from 2012 to 2016 were more likely to be multi-resistant than those isolated from 2017 to 2021, as they were significantly associated with resistance to ≥4 Clinical and Laboratory Standard Institute (CLSI) classes (p = 0.040 and 0.006, respectively). In conclusion, children aged <2 years old were the main pediatric burn patients with wound infections. The primary bacteria isolated from the wound were S. aureus and P. aeruginosa, with a decreasing tendency of multi-resistance.
摘要：
烧伤是全世界儿童死亡和残疾的主要原因之一，伤口感染是烧伤治疗的一大挑战。我们对小儿烧伤患者的创面感染进行了回顾性分析，以揭示其临床资料，调查病原菌的分布和耐药模式，为治疗提供参考。因此,330名患有伤口感染的小儿烧伤患者；65.8％（217/330）<2岁。大多数损伤是烫伤，涉及<10％的全身表面积（TBSA），主要引起II度烧伤和II+III度烧伤。分离出三百五十九株病原菌,主要病原菌为金黄色葡萄球菌(45.4%)和铜绿假单胞菌(18.7%)。与2017年至2021年分离的金黄色葡萄球菌和铜绿假单胞菌相比，2012年至2016年分离的金黄色葡萄球菌和铜绿假单胞菌更可能具有多重耐药性，因为它们与≥4个临床和实验室标准研究所（CLSI）类别的耐药性显着相关（分别为p=0.040和0.006）。总之,<2岁儿童是小儿烧伤创面感染的主要患者。从伤口分离的主要细菌是金黄色葡萄球菌和铜绿假单胞菌，多电阻呈下降趋势。
