目的:关于超重和肥胖儿童和青少年的皮肤特异性发现知之甚少。这项研究评估了皮肤体征与关键的营养和内分泌学参数的关联及其对肥胖年轻人生活质量的影响。
方法:最初招募到三级医院的体重控制计划的所有患者都参加了这一跨学科研究,单中心,横断面研究。所有参与者都接受了详细的皮肤病学检查,人体测量和实验室检查。使用经过验证的问卷评估生活质量。
结果:共有103名儿童和青少年(年龄11.6±2.5岁,41%女性,25%的青春期前,BMISDS2.6±0.5,HOMA评分3.3±4.2;平均值±SD)在12个月的研究期内招募。皮肤影响与BMI增加和年龄增加呈线性相关。最常见的皮肤发现是[%]条(71.0),毛发角化病(64.7),黑棘皮病(45.0),寻常痤疮(39.2),顶索(25.5)和足底角化过度(17.6)。HOMA评分与黑棘皮病相关(p=0.047),毛发角化病(p=0.019)和寻常痤疮(p<0.001)。一般平均生活质量评分,根据WHO-5的评估,100人中有70人。总共38.9%的参与者报告皮肤病学QoL受损。
结论:这项研究表明儿童和青少年肥胖患者皮肤病变的患病率很高。皮肤损伤和HOMA评分之间的关联表明皮肤表现是胰岛素抵抗的标志。为了预防继发性疾病和提高生活质量,彻底的皮肤检查和跨学科合作是必要的。
UNASSIGNED: Little is known about specific cutaneous findings in children and adolescents with overweight and obesity. This study assessed the association of skin signs with pivotal auxological and endocrinological parameters and their influence on the quality of life (QoL) of young people with obesity.
UNASSIGNED: All patients initially recruited for a tertiary hospital\'s weight control program were offered participation in this interdisciplinary, single-center, cross-sectional study. All participants underwent a detailed dermatological examination, anthropometric measurements and laboratory examinations. QoL was assessed with validated questionnaires.
UNASSIGNED: A total of 103 children and adolescents (age 11.6 ±2.5 years, 41% female, 25% prepubertal, BMI SDS 2.6 ± 0.5, homeostatic model assessment (HOMA) score 3.3 ± 4.2; mean ± s.d.) were recruited in a 12-month study period. Skin affections were linearly associated with increasing BMI and higher age. The most common skin findings were (%) striae distensae (71.0), keratosis pilaris (64.7), acanthosis nigricans (45.0), acne vulgaris (39.2), acrochordons (25.5) and plantar hyperkeratosis (17.6). The HOMA score was associated with acanthosis nigricans (P = 0.047), keratosis pilaris (P = 0.019) and acne vulgaris (P < 0.001). The general mean QoL(QoL) score, as assessed by the WHO-5, was 70 out of 100. A total of 38.9% of participants reported impaired dermatological QoL.
UNASSIGNED: This study shows the high prevalence of skin lesions in children and adolescents with obesity. The association between skin lesions and the HOMA score indicates that skin manifestations are a marker of insulin resistance. To prevent secondary diseases and improve QoL, thorough skin examinations and interdisciplinary cooperation are necessary.