背景:毛发角化病(KP)是一种毁容性疾病,对治疗有抵抗力。有几种治疗方法,但疗效有限。这个未来,评估者失明,分体对比研究探讨了长脉冲755nm翠绿宝石激光治疗KP的疗效和安全性。
方法:本研究纳入了22例双侧臂KP患者。所有参与者都被随机分配,并在间隔3周的四个疗程中,在左或右臂上使用长脉冲755nm的翠绿宝石激光治疗。统一的保湿乳液每天一次施用于左臂和右臂。记录医师评估得分和患者自我评估得分,皮肤镜检查的皮肤影像学改变,高频超声,在基线和第四次治疗后4周获得皮肤活检。
结果:在完成研究的21名患者中,15人是女性,6人是男性。在第四次治疗后4周,激光侧显示出明显较低的总量(2.0比4.5),粗糙度(1.0对2.0),根据医生的评估,红肿(1.0对2.0)评分(所有P<0.05)。此外,激光侧显示出明显较低的总量(2.0对4.0),粗糙度(1.0对2.0),根据患者的自我评估,红肿评分(1.0对2.0)(均P<0.05)。通过皮肤镜和超声检查获得卵泡塞改善的患者比例(57.1%对14.3%),毛囊周围红斑(52.4%对9.5%),卵泡周色素沉着过度(47.6%对14.3%),激光侧的表皮凸起数量(57.1%对19.1%)明显高于对照组(均P<0.05)。组织病理学显示,末次访视时滤泡塞和炎性细胞浸润得到改善。三名患者表现出可逆性的炎症后色素沉着过度。
结论:长脉冲755nm翠绿宝石激光治疗对KP皮肤粗糙和发红均有效且安全。
背景:ChiCTR2100054489。
BACKGROUND: Keratosis pilaris (KP) is a disfiguring disease and is resistant to treatment. Several treatment methods are available, but the efficacy is limited. This prospective, rater-blinded, split-body comparative
study investigated the efficacy and safety of long-pulsed 755-nm alexandrite laser in the treatment of KP.
METHODS: Twenty-two patients with KP of bilateral arms were enrolled in this
study. All participants were randomized and treated with a long-pulsed 755-nm alexandrite laser on the left or right arm in four sessions held 3 weeks apart. The unified moisturizing lotion was applied on both left and right arms once a day. Physicians\' assessment scores and patients\' self-assessment scores were recorded, and skin imaging changes in dermoscopy, high-frequency ultrasound, and skin biopsy were obtained at baseline and 4 weeks after the fourth treatment.
RESULTS: Of the 21 patients who completed the
study, 15 were women and 6 were men. At 4 weeks after the fourth treatment, the laser side showed significantly lower total (2.0 versus 4.5), roughness (1.0 versus 2.0), and redness (1.0 versus 2.0) scores according to physicians\' assessment (all P < 0.05). Furthermore, the laser side showed significantly lower total (2.0 versus 4.0), roughness (1.0 versus 2.0), and redness scores (1.0 versus 2.0) according to the patients\' self-assessment (all P < 0.05). The proportions of patients who achieved dermoscopically and ultrasonographically showed excellent improvements in follicular plugs (57.1% versus 14.3%), perifollicular erythema (52.4% versus 9.5%), perifollicular hyperpigmentation (47.6% versus 14.3%), and the number of epidermal bulges (57.1% versus 19.1%) in the laser side was significantly higher than those who achieved such improvements in the control side (all P < 0.05). Histopathology showed that the follicular plugs and inflammatory cell infiltration were improved at the final visit. Three patients exhibited reversible postinflammatory hyperpigmentation.
CONCLUSIONS: Long-pulsed 755-nm alexandrite laser treatment is effective and safe in treating both skin roughness and redness in KP.
BACKGROUND: ChiCTR2100054489.