Abstract：
BACKGROUND: Keratosis pilaris (KP) is a disfiguring disease and is resistant to treatment. Several treatment methods are available, but the efficacy is limited. This prospective, rater-blinded, split-body comparative study investigated the efficacy and safety of long-pulsed 755-nm alexandrite laser in the treatment of KP.
METHODS: Twenty-two patients with KP of bilateral arms were enrolled in this study. All participants were randomized and treated with a long-pulsed 755-nm alexandrite laser on the left or right arm in four sessions held 3 weeks apart. The unified moisturizing lotion was applied on both left and right arms once a day. Physicians\' assessment scores and patients\' self-assessment scores were recorded, and skin imaging changes in dermoscopy, high-frequency ultrasound, and skin biopsy were obtained at baseline and 4 weeks after the fourth treatment.
RESULTS: Of the 21 patients who completed the study, 15 were women and 6 were men. At 4 weeks after the fourth treatment, the laser side showed significantly lower total (2.0 versus 4.5), roughness (1.0 versus 2.0), and redness (1.0 versus 2.0) scores according to physicians\' assessment (all P < 0.05). Furthermore, the laser side showed significantly lower total (2.0 versus 4.0), roughness (1.0 versus 2.0), and redness scores (1.0 versus 2.0) according to the patients\' self-assessment (all P < 0.05). The proportions of patients who achieved dermoscopically and ultrasonographically showed excellent improvements in follicular plugs (57.1% versus 14.3%), perifollicular erythema (52.4% versus 9.5%), perifollicular hyperpigmentation (47.6% versus 14.3%), and the number of epidermal bulges (57.1% versus 19.1%) in the laser side was significantly higher than those who achieved such improvements in the control side (all P < 0.05). Histopathology showed that the follicular plugs and inflammatory cell infiltration were improved at the final visit. Three patients exhibited reversible postinflammatory hyperpigmentation.
CONCLUSIONS: Long-pulsed 755-nm alexandrite laser treatment is effective and safe in treating both skin roughness and redness in KP.
BACKGROUND: ChiCTR2100054489.
METHODS: Twenty-two patients with KP of bilateral arms were enrolled in this study. All participants were randomized and treated with a long-pulsed 755-nm alexandrite laser on the left or right arm in four sessions held 3 weeks apart. The unified moisturizing lotion was applied on both left and right arms once a day. Physicians\' assessment scores and patients\' self-assessment scores were recorded, and skin imaging changes in dermoscopy, high-frequency ultrasound, and skin biopsy were obtained at baseline and 4 weeks after the fourth treatment.
RESULTS: Of the 21 patients who completed the study, 15 were women and 6 were men. At 4 weeks after the fourth treatment, the laser side showed significantly lower total (2.0 versus 4.5), roughness (1.0 versus 2.0), and redness (1.0 versus 2.0) scores according to physicians\' assessment (all P < 0.05). Furthermore, the laser side showed significantly lower total (2.0 versus 4.0), roughness (1.0 versus 2.0), and redness scores (1.0 versus 2.0) according to the patients\' self-assessment (all P < 0.05). The proportions of patients who achieved dermoscopically and ultrasonographically showed excellent improvements in follicular plugs (57.1% versus 14.3%), perifollicular erythema (52.4% versus 9.5%), perifollicular hyperpigmentation (47.6% versus 14.3%), and the number of epidermal bulges (57.1% versus 19.1%) in the laser side was significantly higher than those who achieved such improvements in the control side (all P < 0.05). Histopathology showed that the follicular plugs and inflammatory cell infiltration were improved at the final visit. Three patients exhibited reversible postinflammatory hyperpigmentation.
CONCLUSIONS: Long-pulsed 755-nm alexandrite laser treatment is effective and safe in treating both skin roughness and redness in KP.
BACKGROUND: ChiCTR2100054489.
摘要：
背景：毛发角化病（KP）是一种毁容性疾病，对治疗有抵抗力。有几种治疗方法，但疗效有限。这个未来,评估者失明，分体对比研究探讨了长脉冲755nm翠绿宝石激光治疗KP的疗效和安全性。
方法：本研究纳入了22例双侧臂KP患者。所有参与者都被随机分配，并在间隔3周的四个疗程中，在左或右臂上使用长脉冲755nm的翠绿宝石激光治疗。统一的保湿乳液每天一次施用于左臂和右臂。记录医师评估得分和患者自我评估得分，皮肤镜检查的皮肤影像学改变，高频超声,在基线和第四次治疗后4周获得皮肤活检。
结果：在完成研究的21名患者中，15人是女性，6人是男性。在第四次治疗后4周，激光侧显示出明显较低的总量（2.0比4.5），粗糙度（1.0对2.0），根据医生的评估，红肿（1.0对2.0）评分（所有P<0.05）。此外，激光侧显示出明显较低的总量（2.0对4.0），粗糙度（1.0对2.0），根据患者的自我评估，红肿评分（1.0对2.0）（均P<0.05）。通过皮肤镜和超声检查获得卵泡塞改善的患者比例（57.1％对14.3％），毛囊周围红斑（52.4%对9.5%），卵泡周色素沉着过度（47.6％对14.3％），激光侧的表皮凸起数量（57.1％对19.1％）明显高于对照组（均P<0.05）。组织病理学显示，末次访视时滤泡塞和炎性细胞浸润得到改善。三名患者表现出可逆性的炎症后色素沉着过度。
结论：长脉冲755nm翠绿宝石激光治疗对KP皮肤粗糙和发红均有效且安全。
背景：ChiCTR2100054489。
方法：本研究纳入了22例双侧臂KP患者。所有参与者都被随机分配，并在间隔3周的四个疗程中，在左或右臂上使用长脉冲755nm的翠绿宝石激光治疗。统一的保湿乳液每天一次施用于左臂和右臂。记录医师评估得分和患者自我评估得分，皮肤镜检查的皮肤影像学改变，高频超声,在基线和第四次治疗后4周获得皮肤活检。
结果：在完成研究的21名患者中，15人是女性，6人是男性。在第四次治疗后4周，激光侧显示出明显较低的总量（2.0比4.5），粗糙度（1.0对2.0），根据医生的评估，红肿（1.0对2.0）评分（所有P<0.05）。此外，激光侧显示出明显较低的总量（2.0对4.0），粗糙度（1.0对2.0），根据患者的自我评估，红肿评分（1.0对2.0）（均P<0.05）。通过皮肤镜和超声检查获得卵泡塞改善的患者比例（57.1％对14.3％），毛囊周围红斑（52.4%对9.5%），卵泡周色素沉着过度（47.6％对14.3％），激光侧的表皮凸起数量（57.1％对19.1％）明显高于对照组（均P<0.05）。组织病理学显示，末次访视时滤泡塞和炎性细胞浸润得到改善。三名患者表现出可逆性的炎症后色素沉着过度。
结论：长脉冲755nm翠绿宝石激光治疗对KP皮肤粗糙和发红均有效且安全。
背景：ChiCTR2100054489。
