BACKGROUND: The pathological examination of a medicolegal autopsy is a great learning opportunity for a pathologist as well as for a forensic expert, where the cause of death remains unknown. Liver disease epidemiology differs from one geographic area to another.
METHODS: This was a prospective observational study with 100 medicolegal autopsy cases over a one-year period conducted in the Department of Forensic Medicine and Toxicology (FMT) and Pathology. Representative tissue from the liver was collected in 10% neutral buffered formalin and sent for histopathological examination.
RESULTS: The mean age of the cases was 41.98 ± 15.39 years, and ages ranged from 20 to 90 years with male preponderance. The most common histopathology and gross findings noted were mild to moderate chronic hepatitis (CH) (54%) and fatty change (36%), respectively. There was a significant association (p ≤ 0.05) between histopathology and gross findings, cause, and manner of death.
CONCLUSIONS: Gross and histopathological examination of the liver in a medicolegal autopsy has a significant role in ascertaining the cause and manner of death.

BACKGROUND: Most cancer patients undergoing chemotherapy develop anemia during their course of treatment. There is a need for early treatment for chemotherapy-induced anemia to prevent morbidity and mortality.
METHODS: This is a hospital-based study, conducted over one year and included 59 children who are known cases of hematological malignancy aged up to 18 years. Standard methods were used to measure micronutrients and complete blood count. Statistical analysis was done using SPSS for Windows, Version 15.0 (Released 2006; SPSS Inc., Chicago, United States).
RESULTS: The majority of subjects (n=21; 35.6%) were aged six to nine years with male dominance. Micronutrient deficiency and significant anemia were noted in 40-50% and 64.4% of cases, respectively. Both malignancy and blood indices showed no association with micronutrients.
CONCLUSIONS: Anemia with micronutrient deficiency is common in children with hematopoietic malignancies receiving chemotherapy. However, no significant association was noted between red cell indices and levels of micronutrients.

Background Long-term metformin treatment in individuals with type 2 diabetes mellitus causes vitamin B12 insufficiency, which is typically neglected, undetected, and under-treated. A severe deficit may cause life-threatening neurological problems. This study assessed the prevalence of vitamin B12 deficiencies among T2DM patients and its factors at a tertiary hospital in the Tamil Nadu district of Salem. Materials and Methods This is an analytical cross-sectional study conducted in a tertiary care hospital in the Salem district, Tamil Nadu, India. Patients with type 2 diabetes mellitus who were prescribed metformin at the outpatient department of general medicine took part in the trial. Our research instrument was a structured questionnaire. We used a questionnaire containing information on sociodemographic characteristics, metformin use among diabetic mellitus patients, diabetes mellitus history, lifestyle behaviors, anthropometric measurement, examination findings, and biochemical markers. Prior to administering the interview schedule, each participant\'s parents provided written informed consent. A thorough medical history, physical exam, and anthropometric examination were performed. Data were entered in Microsoft Excel (Microsoft Corporation, Redmond, WA) and analyzed using SPSS version 23 (IBM Corp., Armonk, NY). Results Among the study participants, we diagnosed nearly 43% of diabetes cases in participants between the ages of 40-50 years, while we diagnosed 39% aged under 40 years. Nearly 51% had diabetes for 5-10 years, while only 14% had diabetes for over 10 years. In addition, 25% of the study sample had a positive family history of type 2 diabetes. Nearly 48% and 13% of the study group had been on metformin for 5-10 years and >10 years, respectively. The majority, 45%, were found to take 1000 mg of metformin per day, whereas just 15% take 2 g per day. In our study, the prevalence of vitamin B12 insufficiency was 27%, and nearly 18% had borderline levels. The duration of diabetes mellitus, the duration of metformin intake, and the dose of metformin were statistically significant (p-value = 0.05) among the variables associated with diabetes mellitus and vitamin B12 deficiency. Conclusion The results of the study show that a deficiency in vitamin B12 increases the likelihood that diabetic neuropathy would worsen. Therefore, individuals with diabetes who take larger dosages of metformin (more than 1000mg) for an extended period must have their vitamin B12 levels monitored often. Preventative or therapeutic vitamin B12 supplementation can mitigate this issue.

Background Sugar is a ubiquitous element in processed meals and is a major source of the energy we derive from them. The risk of obesity and other chronic conditions, such as high blood pressure, cardiovascular disease, type 2 diabetes mellitus, tooth destruction, as well as dental cavities, increases proportionally with the consumption of sugar-sweetened beverages (SSBs). This study intends to determine the prevalence of SSB intake among adults in the Perambalur area of Tamil Nadu, India, as well as the factors that influence it. Methodology We surveyed 1007 individuals using a cross-sectional design from June to November 2022. We included residents who were at least 18 years old and less than 80 years old. Using a convenience sample method, we gathered responses from the public in the urban and rural field practice areas of a teaching medical college in the district of Perambalur, India. We conducted in-person interviews to get data regarding the consumption of SSBs. Among other socio-demographic information, the participants\' names, ages, religions, levels of education and employment, household incomes, family compositions, marital statuses, lifestyle behaviors, and comorbid conditions were also gathered. We measured the SSB consumption frequency and duration, and we also considered the contexts in which they consumed SSBs. We examined the factors that play a role in SSB consumption and questioned the participants\' familiarity with SSBs\' constituents, adverse effects, and cumulative toll. Besides examining the effects of SSB use, the research also explores the possibility of reducing or stopping it altogether. Results The prevalence of SSB use among the current study population was 96.3%. Half of the population has consumed SSBs, between 100 and 200 ml, for over 10 years. Taste and peer pressure are the primary reasons for facilitating SSBs, whereas the media has a minor impact. Most of the population (69%) began consuming SSBs, mostly during vacations and at parties. About one-fifth of the population experiences negative consequences after ingesting SSBs, while only half of the population is aware of the contents of SSBs. Likewise, just 50% of the population is aware of the long-term implications of SSBs. Nearly 16.7% of the population attempted to stop using SSBs. Being overweight, belonging to a high socioeconomic class, and dwelling in a rural location are risk factors related to the consumption of SSBs. Conclusion The prevalence of SSB use among the current study population is exceptionally high. Being overweight, belonging to a high socioeconomic class, and dwelling in a rural location are risk factors related to the consumption of SSBs. There is a need to educate the public about the short- and long-term negative effects of consuming SSBs. Government and non-government entities must work together to generate public behavior change communication.

Pathological examination (PE) encompasses a gross or macroscopy and histopathological or microscopic examination. It is prudent in finding the cause of death (COD) in clinical and medicolegal autopsies. There are various auxiliary techniques in the form of clinical history, communication, specialized training, and protocols for consolidation of the PE results. After a thorough search of the literature in PubMed with relevant keywords along with further analysis of the results, it emerged that even with the modernization of forensic medicine, a PE is unbeatable in detecting the COD. It has various useful aspects, apart from regular finding the COD, such as in student teaching, epidemiology of disease, audit tool, and quality assurance. There are also limitations of PE, which should be dealt with great caution. Hence, limitations must be understood by a forensic expert as well as a pathologist. In this review, all factors that are related to PE in any manner are discussed in detail, and the scope for improving the quality of PE to be relevant in the present scenario is reviewed. It is a comprehensive reassessment of the literature review that also casts light on the future along with a critical analysis of the facts that deal with PE.