目的:为了评估供体配子的利用率,患者满意度,和使用供体配子进行治疗的患者的生育治疗结果,根据配子供体的期望种族和种族进行分层。
方法:调查研究对象:计划在2015年至2020年间在美国东南部的一家学术生育诊所使用供体精子和/或供体卵母细胞进行治疗的患者。
■无主要结果指标:供体配子的利用率,对供体配子选择和生育治疗结果的满意度按患者的种族和种族分层,以及他们的配子捐赠者。
结果:四百五十名患者符合纳入条件,有170名(38%)对调查做出了回应。在受访者中,59%希望非西班牙裔白配子供体,20%希望非西班牙裔黑配子供体。与寻求非西班牙裔白人配子供体的个体相比,寻求非西班牙裔黑人配子供体的患者使用供体配子的几率较低(OR=0.13,95%CI0.04-0.40)。在评估对供体配子选择的满意度时,寻求非西班牙裔黑人配子供体的患者报告的满意度低于寻求非西班牙裔白人配子供体的患者(OR0.19,95%CI[0.09-0.43]).在评估生育结果时,与非西班牙裔白人患者(OR=0.18,95%CI0.07-0.46)和寻求非西班牙裔白人配子供体的个体相比,非西班牙裔黑人患者和使用非西班牙裔黑人配子供体的成功受孕几率较低。(OR=0.26,95%CI0.09-0.75),分别。
结论:寻求非西班牙裔黑人供体配子的患者利用率较低,对配子供体选择的满意度较低,与寻求非西班牙裔白人配子捐赠者的人相比,受孕几率较低。这些发现强调了捐助者配子银行内部需要更多的种族多样性,以及通过机构和生育诊所提供的捐助者池中。
OBJECTIVE: To evaluate donor gamete utilization, patient satisfaction, and fertility treatment outcomes of patients pursuing treatment with donor gametes stratified by the desired race and ethnicity of the gamete
donor.
METHODS: Survey study SUBJECTS: Patients planning to undergo treatment using donor sperm and/or donor oocytes at a single academic fertility clinic in the Southeastern United States between 2015 and 2020.
UNASSIGNED: None MAIN OUTCOME MEASURES: Utilization rates of donor gametes, satisfaction with donor gamete selection and fertility treatment outcomes stratified by race and ethnicity of patient, as well as that of their gamete
donor.
RESULTS: Four hundred fifty patients were eligible for inclusion and 170 (38%) responded to the survey. Amongst the respondents, 59% desired a non-Hispanic White gamete donor and 20% desired a non-Hispanic Black gamete
donor. Patients seeking a non-Hispanic Black gamete
donor had lower odds of utilizing
donor gametes (OR = 0.13, 95% CI 0.04 - 0.40) compared to individuals seeking a non-Hispanic White gamete donor. When evaluating satisfaction with donor gamete selection, patients seeking a non-Hispanic Black gamete
donor reported lower satisfaction compared to individuals seeking a non-Hispanic White gamete
donor (OR 0.19, 95% CI [0.09-0.43]). When evaluating fertility outcomes, Non-Hispanic Black patients and those utilizing non-Hispaninc Black gamete donors were found to have a lower odds of successful conception compared to non-Hispanic White patients (OR=0.18, 95% CI 0.07-0.46) and individuals seeking non-Hispanic White gamete donors (OR=0.26, 95% CI 0.09-0.75), respectively.
CONCLUSIONS: Patients seeking non-Hispanic Black donor gametes have lower utilization rates, less satisfaction with gamete donor selection, and lower odds of conception when compared to those seeking non-Hispanic White gamete donors. These findings highlight the need for more racial diversity within donor gamete banks, as well as within the donor pools available through agencies and fertility clinics.