PDF(Pubmed)
Abstract：
The novelty and the essential purpose of this research is the preparation of new anti-inflammatory iron complexes in water green solvent using critical micelle concentration of anionic surface active agent (SAA). Three new anti-inflammatory iron complexes have been prepared. Thiophene-electron (es) donor (D) Schiff base (2-(2-OH-benzylidene)-amino)-4, 5, 6, 7-tetrah ydrobenzo[b] thiophene-3-carbonitrile) has been prepared. Molecular structures of all samples were confirmed based on CNH analysis, 1H NMR and 13C NMR spectra. The molecular structure of Schiff base is further confirmed by computational chemistry using the DFT-B3LYP method, 6-31G (d) basis set. Observed and simulated 1H NMR, UV-Vis. IR/Raman spectra confirmed the molecular structure of D. This Schiff base is intercalated to ferric chloride (FeCl3) giving pure iron charge transfer complex (CTCs). In vitro and kinetic studies confirmed Fe-CTC complexes had (concentration-dependent) potent antimicrobial-, good anti-inflammatory activities. Free radical scavenging activity nitrous oxide (NO.) of Fe (III)CTCs is attributed to geometry Fe(III) ions as distorted octahedral (either monoclinic or triclinic single crystals) via functional groups (-C]N-O, NH2). Elemental analysis and EDS spectra confirmed strong binding between iron and hetero atoms (N, S, O) of D molecules.
摘要：
本研究的新颖性和基本目的是使用阴离子表面活性剂（SAA）的临界胶束浓度在水绿色溶剂中制备新型抗炎铁配合物。已经制备了三种新的抗炎铁复合物。噻吩电子给体（D）席夫碱（2-（2-OH-亚苄基）-氨基）-4，5，6，7-四羟基苯并[b]噻吩-3-甲腈）已制备。基于CNH分析确认了所有样品的分子结构,1HNMR和13CNMR光谱。通过使用DFT-B3LYP方法的计算化学进一步证实了席夫碱的分子结构，6-31G(D)基准集。观察和模拟1HNMR，UV-Vis。红外/拉曼光谱证实了D的分子结构。将该席夫碱插入氯化铁（FeCl3）中，得到纯铁电荷转移络合物（CTC）。体外和动力学研究证实Fe-CTC复合物具有（浓度依赖性）有效的抗微生物剂-，良好的抗炎活性。自由基清除活性一氧化二氮（NO。）的Fe（III）CTC归因于几何形状的Fe（III）离子通过官能团（-C]N-O变形为八面体（单斜晶系或三斜晶系单晶），NH2)。元素分析和EDS光谱证实了铁与杂原子之间的强结合（N，S,D分子的O)。
