■这项研究是为了研究玉米丝提取物在尼古丁给药的雄性小鼠中的降血脂和保肝作用。
■尼古丁可通过氧化应激和损伤细胞在肝组织中产生病理生理作用。玉米丝具有抗氧化作用,可改善肝功能。
■在本实验研究中,将30只雄性NMRI小鼠(25-30gr)分为5组:对照组,sham,尼古丁2.5mg/kg,尼古丁+玉米丝的水提取物400毫克/千克,和尼古丁+玉米丝的甲醇提取物400mg/kg,持续1个月。在最后一次尼古丁和提取物消耗后的一天,血清样本进行生化测量,和匀浆肝脏的上清液用于抗氧化变量评估。
■不同组的体重没有显着差异。与对照组相比,烟碱组肝脏重量和GSH降低(P<0.05)。甘油三酯,总胆固醇,HDL-C,LDL-C,肝酶,与对照组相比,烟碱组MDA升高(P<0.05)。此外,正弦曲线的扩张,炎症细胞的存在,与对照组相比,尼古丁组观察到肝细胞坏死。在接受尼古丁的小鼠中使用玉米丝的水性和甲醇提取物导致所述变量的改善(P<0.05)。
■这项研究的结果表明,使用尼古丁可导致肝毒性的诱导。玉米丝的水性和甲醇提取物的使用通过其抗氧化活性改善了它们。
UNASSIGNED: This study is done to investigate the hypolipidemic and hepatoprotective effects of corn silk extract in nicotine-administered male mice.
UNASSIGNED: Nicotine can induce pathophysiological effects in the liver tissue through oxidative stress and damage cells. Corn silk can improve liver function with its antioxidant effects.
UNASSIGNED: In this experimental study, 30 male NMRI mice (25-30 gr) were divided into 5 groups: controls, sham, nicotine 2.5 mg/kg, nicotine+aqueous extract of corn silk 400 mg/kg, and nicotine+methanolic extract of corn silk 400 mg/kg for 1 month. One day after the last nicotine and extracts consumption, the serum samples were performed for biochemical measurement, and the supernatant of the homogenized liver was administered for antioxidant variables assessment.
UNASSIGNED: There was no significant difference in the body weight of different groups. Liver weight and GSH decreased in the nicotine group compared to the control group (P<0.05). Triglycerides, total cholesterol, HDL-C, LDL-C, liver enzymes, and MDA increased in the nicotine group compared to the control group (P<0.05). Also, the expansion of sinusoids, the presence of inflammatory cells, and necrosis of liver cells were observed in the nicotine group compared to the control group. Using aqueous and methanolic extracts of corn silk in mice receiving nicotine led to the improvement of the mentioned variables (P<0.05).
UNASSIGNED: The results of this study showed that the use of nicotine can lead to the induction of hepatotoxicity. The use of aqueous and methanolic extracts of corn silk improved them through its antioxidant activity.