■使用磁共振成像(MRI)对脊髓损伤(SCI)个体的脊髓病变和备用神经组织进行量化的全球兴趣越来越大。这项研究的主要目的是评估MRI评估的脊髓病变特征与肠道之间的关系,膀胱,和SCI后的整体独立性。
■回顾性,探索性研究。
■从2010年至2017年在美国当地模型系统SCI数据库中登记的93例宫颈SCI患者。
■获得了潜在参与者的临床和MRI数据,并对符合条件的参与者进行了MRI分析.解释变量,在核磁共振成像上捕获,包括髓内病变长度(IMLL),正中矢状腹侧组织桥宽度(VTBW),正中矢状背组织桥宽度(DTBW),和轴向损伤比(ADR)。
■肠和膀胱管理量表的功能独立性测量(FIM)和FIM总运动评分。
■当考虑所有四个变量时,只有ADR与肠独立性显著相关(OR=0.970,95%CI:0.942-0.997,P=0.030),ADR和IMLL均与膀胱独立性密切相关(OR=0.967,95%CI:0.936-0.999,P=0.046和OR=0.948,95%CI:0.919-0.978,P=0.0007)。所有四个预测变量都解释了总体独立性得分的32%的变化,但在考虑所有其他预测变量后,只有ADR与整体独立性显着相关(β=-0.469,95%CI:-0.719,-0.218,P=0.0004)。
■我们的结果表明,MRI测量的脊髓病变程度可以预测肠道,膀胱,宫颈SCI后的整体独立性。
UNASSIGNED: There is a growing global interest in quantifying spinal cord lesions and spared neural tissue using magnetic resonance imaging (MRI) in individuals with spinal cord injury (SCI). The primary objective of this study was to assess the relationships between spinal cord lesion characteristics assessed on MRI and
bowel, bladder, and overall independence following SCI.
UNASSIGNED: Retrospective, exploratory study.
UNASSIGNED: 93 individuals with cervical SCI who were enrolled in a local United States Model Systems SCI database from 2010 to 2017.
UNASSIGNED: Clinical and MRI data were obtained for potential participants, and MRIs of eligible participants were analyzed. Explanatory variables, captured on MRIs, included intramedullary lesion length (IMLL), midsagittal ventral tissue bridge width (VTBW), midsagittal dorsal tissue bridge width (DTBW), and axial damage ratio (ADR).
UNASSIGNED: Bowel and bladder management scale of the Functional Independence Measure (FIM) and FIM total motor score.
UNASSIGNED: When accounting for all four variables, only ADR was significantly associated with
bowel independence (OR = 0.970, 95% CI: 0.942-0.997, P = 0.030), and both ADR and IMLL were strongly associated with bladder independence (OR = 0.967, 95% CI: 0.936-0.999, P = 0.046 and OR = 0.948, 95% CI: 0.919-0.978, P = 0.0007, respectively). 32% of the variation in overall independence scores were explained by all four predictive variables, but only ADR was significantly associated with overall independence after accounting for all other predictive variables (β = -0.469, 95% CI: -0.719, -0.218, P = 0.0004).
UNASSIGNED: Our results suggest that the MRI-measured extent of spinal cord lesion may be predictive of
bowel, bladder, and overall independence following cervical SCI.