PDF(Pubmed)
Abstract：
BACKGROUND: Anastomotic leaks remain one of the most dreaded complications in gastrointestinal surgery causing significant morbidity, that negatively affect the patients\' quality of life. Experimental studies play an important role in understanding the pathophysiological background of anastomotic healing and there are still many fields that require further investigation. Knowledge drawn from these studies can lead to interventions or techniques that can reduce the risk of anastomotic leak in patients with high-risk features. Despite the advances in experimental protocols and techniques, designing a high-quality study is still challenging for the investigators as there is a plethora of different models used.
OBJECTIVE: To review current state of the art for experimental protocols in high-risk anastomosis in rats.
METHODS: This systematic review was performed according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. To identify eligible studies, a comprehensive literature search was performed in the electronic databases PubMed (MEDLINE) and Scopus, covering the period from conception until 18 October 2023.
RESULTS: From our search strategy 102 studies were included and were categorized based on the mechanism used to create a high-risk anastomosis. Methods of assessing anastomotic healing were extracted and were individually appraised.
CONCLUSIONS: Anastomotic healing studies have evolved over the last decades, but the findings are yet to be translated into human studies. There is a need for high-quality, well-designed studies that will help to the better understanding of the pathophysiology of anastomotic healing and the effects of various interventions.
OBJECTIVE: To review current state of the art for experimental protocols in high-risk anastomosis in rats.
METHODS: This systematic review was performed according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. To identify eligible studies, a comprehensive literature search was performed in the electronic databases PubMed (MEDLINE) and Scopus, covering the period from conception until 18 October 2023.
RESULTS: From our search strategy 102 studies were included and were categorized based on the mechanism used to create a high-risk anastomosis. Methods of assessing anastomotic healing were extracted and were individually appraised.
CONCLUSIONS: Anastomotic healing studies have evolved over the last decades, but the findings are yet to be translated into human studies. There is a need for high-quality, well-designed studies that will help to the better understanding of the pathophysiology of anastomotic healing and the effects of various interventions.
摘要：
背景：吻合口瘘仍然是胃肠道手术中最可怕的并发症之一，会导致严重的发病率，对患者的生活质量产生负面影响。实验研究在了解吻合口愈合的病理生理学背景中起着重要作用，仍有许多领域需要进一步研究。从这些研究中获得的知识可以导致干预措施或技术，可以降低具有高风险特征的患者的吻合口瘘风险。尽管实验方案和技术取得了进展，对于研究者来说,设计高质量的研究仍然具有挑战性,因为使用了大量不同的模型.
目的：回顾目前在大鼠中进行高风险吻合的实验方案。
方法：本系统评价是根据系统评价和荟萃分析指南的首选报告项目进行的。为了确定符合条件的研究，在电子数据库PubMed(MEDLINE)和Scopus中进行了全面的文献检索，涵盖从受孕到2023年10月18日的时期。
结果：从我们的搜索策略中，纳入了102项研究，并根据用于创建高风险吻合的机制进行了分类。提取吻合口愈合的评估方法，并进行单独评估。
结论：吻合口愈合研究在过去的几十年中不断发展，但是这些发现尚未转化为人类研究。需要高质量的，精心设计的研究，这将有助于更好地了解吻合口愈合的病理生理学和各种干预措施的效果。
目的：回顾目前在大鼠中进行高风险吻合的实验方案。
方法：本系统评价是根据系统评价和荟萃分析指南的首选报告项目进行的。为了确定符合条件的研究，在电子数据库PubMed(MEDLINE)和Scopus中进行了全面的文献检索，涵盖从受孕到2023年10月18日的时期。
结果：从我们的搜索策略中，纳入了102项研究，并根据用于创建高风险吻合的机制进行了分类。提取吻合口愈合的评估方法，并进行单独评估。
结论：吻合口愈合研究在过去的几十年中不断发展，但是这些发现尚未转化为人类研究。需要高质量的，精心设计的研究，这将有助于更好地了解吻合口愈合的病理生理学和各种干预措施的效果。
