背景:阴性症状(消除,快感缺失,性)是精神病患者中普遍存在的症状,在普通人群中也出现在亚临床水平。最近的工作已经开始研究环境背景(例如位置)如何影响负面症状。然而,有限的工作已经评估了环境如何导致临床精神病(CHR)高危青少年的阴性症状.当前的研究使用生态瞬时评估来评估四个环境背景(位置,活动,社交互动,社会互动方法)影响CHR和健康对照(CN)参与者阴性症状的状态波动。
方法:CHR青年(n=116)和CN(n=61)完成了为期6天的8项每日调查,评估阴性症状和背景。
结果:混合效应模型表明,在两组中,阴性症状在不同情况下差异很大。在大多数情况下,CHR参与者的阴性症状高于CN参与者,但是在娱乐活动和电话互动中,两组的症状减轻相似。在CHR参与者中,阴性症状在几种情况下升高,包括学习/工作,通勤,吃,跑腿,在家.
结论:结果表明,在CHR参与者中,阴性症状在某些情况下动态变化。在某些情况下,阴性症状更完整,而其他情况下,特别是一些用于促进功能恢复,可能会加剧CHR的阴性症状。研究结果表明,在了解CHR参与者的阴性症状的状态波动时,应考虑环境因素。
BACKGROUND: Negative symptoms (avolition, anhedonia,
asociality) are a prevalent symptom in those across the psychosis-spectrum and also occur at subclinical levels in the general population. Recent work has begun to examine how environmental contexts (e.g. locations) influence negative symptoms. However, limited work has evaluated how environments may contribute to negative symptoms among youth at clinical high risk for psychosis (CHR). The current study uses Ecological Momentary Assessment to assess how four environmental contexts (locations, activities, social interactions, social interaction method) impact state fluctuations in negative symptoms in CHR and healthy control (CN) participants.
METHODS: CHR youth (n = 116) and CN (n = 61) completed 8 daily surveys for 6 days assessing negative symptoms and contexts.
RESULTS: Mixed-effects modeling demonstrated that negative symptoms largely varied across contexts in both groups. CHR participants had higher negative symptoms than CN participants in most contexts, but groups had similar symptom reductions during recreational activities and phone call interactions. Among CHR participants, negative symptoms were elevated in several contexts, including studying/working, commuting, eating, running errands, and being at home.
CONCLUSIONS: Results demonstrate that negative symptoms dynamically change across some contexts in CHR participants. Negative symptoms were more intact in some contexts, while other contexts, notably some used to promote functional recovery, may exacerbate negative symptoms in CHR. Findings suggest that environmental factors should be considered when understanding state fluctuations in negative symptoms among those at CHR participants.