PDF(Pubmed)
Abstract：
Negative symptoms (i.e., anhedonia, avolition, asociality, blunted affect, alogia) are frequently observed in the schizophrenia-spectrum (SZ) and associated with functional disability. While semi-structured interviews of negative symptoms represent a gold-standard approach, they require specialized training and may be vulnerable to rater biases. Thus, brief self-report questionnaires measuring negative symptoms may be useful. Existing negative symptom questionnaires demonstrate that this approach may be promising in schizophrenia, but no measure has been devised for use across stages of psychotic illness. The present study reports initial psychometric validation of the Negative Symptom Inventory-Self-Report (NSI-SR), the self-report counterpart of the Negative Symptom Inventory-Psychosis Risk clinical interview. The NSI-SR is a novel transphasic negative symptoms measure assessing the domains of anhedonia, avolition, and asociality. The NSI-SR and related measures were administered to two samples: 1) undergraduates (n = 335), 2) community participants, including: SZ (n = 32), clinical-high risk for psychosis (CHR, n = 25), and healthy controls matched to SZ (n = 31) and CHR (n = 30). The psychometrically trimmed 11-item NSI-SR showed good internal consistency and a three-factor solution reflecting avolition, asociality, and anhedonia. The NSI-SR demonstrated convergent validity via moderate to large correlations with clinician-rated negative symptoms and related constructs in both samples. Discriminant validity was supported by lower correlations with positive symptoms in both samples; however, correlations with positive symptoms were still significant. These initial psychometric findings suggest that the NSI-SR is a reliable and valid brief questionnaire capable of measuring negative symptoms across phases of psychotic illness.
摘要：
阴性症状(即，快感缺失,废除,asociality,钝的影响，alogia）在精神分裂症谱（SZ）中经常观察到，并与功能障碍有关。虽然负面症状的半结构化访谈代表了一种黄金标准方法，他们需要专门的培训，可能容易受到评估者的偏见。因此，简短的自我报告问卷测量阴性症状可能是有用的。现有的阴性症状问卷表明，这种方法在精神分裂症中可能是有希望的，但是还没有设计出适用于不同阶段精神病的措施。本研究报告了阴性症状清单-自我报告(NSI-SR)的初步心理测量验证，阴性症状量表-精神病风险临床访谈的自我报告副本。NSI-SR是一种新型的跨相阴性症状指标，用于评估快感缺失的领域，废除,和自我意识。对两个样本进行了NSI-SR和相关测量：1)本科生(n=335)，2）社区参与者，包括：SZ(n=32)，精神病的临床高风险(CHR，n=25),健康对照与SZ(n=31)和CHR(n=30)匹配。经过心理测量的11项NSI-SR显示出良好的内部一致性和反映消除的三因素解决方案，asociality,和快感缺乏症。NSI-SR通过与临床医生评估的阴性症状和两个样本中的相关结构的中等到大的相关性证明了收敛有效性。两个样本中与阳性症状的相关性较低，支持了判别有效性；然而，与阳性症状的相关性仍然显着。这些初步的心理测量结果表明，NSI-SR是一种可靠且有效的简短问卷，能够测量精神病各个阶段的阴性症状。
