METHODS: Fifty-two outpatients with SZ and 55 healthy controls (CN) completed 6 days of EMA. Multilevel models examined concurrent and time-lagged associations between DPB and negative symptoms in daily life.
RESULTS: SZ displayed greater DPB in daily life than CN. Furthermore, greater DPB were associated with greater concurrently assessed negative symptoms (anhedonia, avolition, and asociality) in daily life. Time-lagged analyses indicated that in both groups, greater DPB at time t led to elevations in negative symptoms (anhedonia, avolition, or asociality) at t + 1 above and beyond the effects of negative symptoms at time t.
CONCLUSIONS: Results support the ecological validity of the Cognitive Model of Negative Symptoms and identify a temporally specific association between DPB and subsequent negative symptoms that is consistent with the model\'s hypotheses and a putative mechanistic pathway in Cognitive Behavioral Therapy for negative symptoms. Findings suggest that DPB are a psychological factor contributing to negative symptoms in real-world environments. Implications for measuring DPB in daily life and providing just-in-time mobile health-based interventions to target this mechanism are discussed.
方法:52名SZ门诊患者和55名健康对照(CN)完成了6天的EMA治疗。多水平模型检查了DPB与日常生活中阴性症状之间的并发和时滞关联。
结果:SZ在日常生活中显示出比CN更高的DPB。此外,更高的DPB与更高的同时评估的阴性症状相关(快感缺失,废除,和可用性)在日常生活中。时滞分析表明,在两组中,在时间t增加DPB导致阴性症状升高(快感缺失,废除,在t1时高于或超出时间t时阴性症状的影响。
结论:结果支持阴性症状认知模型的生态有效性,并确定了DPB与随后的阴性症状之间的时间特异性关联,这与模型的假设和阴性症状认知行为治疗中假定的机制途径一致。研究结果表明,DPB是导致现实环境中负面症状的心理因素。讨论了在日常生活中测量DPB并提供基于实时移动健康的干预措施以针对该机制的含义。