■最近的研究表明,精神分裂症阴性症状有五个方面:快感缺失,asociality,废除,钝的影响,和alogia。在社区居住的患者中,意识到了一种特征性症状。然而,很少有研究探讨这些症状与长期住院的关系.
■本研究探讨了两组精神分裂症患者(长期住院患者和社区居住患者)的五个阴性症状领域中每一个的相对关联。
■参与者包括日本Nasukougen医院的56名长期住院患者和111名社区居住患者。使用卡尺内的最近邻匹配。按年龄匹配参与者后,性别,疾病持续时间,和多年的教育,每组分配30名参与者.模型1用5个子域作为自变量的逻辑回归分析进行分析。模型2在添加阳性症状后进行分析,认知功能,功能技能,以及在模型1中显著的子结构域的功能结果。
■结果表明,性生活与长期住院显著相关。当增加精神分裂症的特征性临床因素时,asociality,日常生活技能,社会和角色功能被发现是长期住院的特征。在阴性症状中,在预后不良的人群中,缺乏社会动机更具特征。
■在与长期住院相关的阴性症状中,asociality,缺乏社会动机,与社区居住患者的功能结局密切相关,而不是消除。需要进一步的研究来建立因果关系,因为它可能具有治疗意义。
UNASSIGNED: Recent studies suggest five domains for negative schizophrenia symptoms: anhedonia,
asociality, avolition, blunted affect, and alogia. Avolition has been considered a characteristic symptom in community-dwelling patients. However, few studies have explored the association of these symptoms with long-term hospitalization.
UNASSIGNED: This study explored the relative association of each of the five domains of negative symptoms in two groups of patients with schizophrenia: long-term hospitalized and community-dwelling patients.
UNASSIGNED: Participants included 56 long-term inpatients and 111 community-dwelling patients at Nasukougen Hospital in Japan. The nearest neighbor matching within caliper was used. After matching participants by age, sex, disease duration, and years of education, each group was assigned 30 participants. Model 1 was analyzed with a logistic regression analysis with 5 subdomains as independent variables. Model 2 was analyzed after adding positive symptoms, cognitive function, functional skills, and functional outcomes to the subdomains that were significant in model 1.
UNASSIGNED: The results indicated that
asociality was significantly associated with long-term hospitalization. When the characteristic clinical factors of schizophrenia were added,
asociality, daily living skills, and social and role functions were found to be characteristic of long-term hospitalization. Among the negative symptoms, lack of social motivation was more characteristic among the group with a poor prognosis.
UNASSIGNED: Of the negative symptoms associated with long-term hospitalization,
asociality, lack of social motivation, rather than avolition was found to be most strongly associated with community-dwelling patients\' functional outcomes. Further studies are required to establish a causal association as it may have therapeutic implications.