PDF(Pubmed)
Abstract：
Evidence regarding the association of Negative Symptoms (NS) dimensions with Health-related Quality of Life (HRQoL) is limited and no prior study has looked into contributions of NS domains on HRQoL. This study bridges the gap by examining the associations of NS, its two dimensions (Motivation and Pleasure, and Emotional Expressivity) and five domains (Anhedonia, Avolition, Asociality, Blunted affect and Alogia) with HRQoL in schizophrenia. 274 individuals with schizophrenia were assessed on the Positive and Negative Syndrome Scale (PANSS) and Brief Negative Symptom Scale (BNSS). PANSS scores were mapped to EuroQol five-dimensional (EQ-5D-5L) utility scores using an algorithm previously validated in Singapore, and the resulting EQ-5D-5L scores were used as a measure of HRQoL. Multiple linear regression analyses of the two NS dimensions and five NS domains against EQ-5D-5L showed that a lower severity of NS, specifically that of the Motivation and Pleasure (MAP) dimension and asociality domain was associated with higher HRQoL. Our findings highlight the importance of targeting NS, particularly MAP and asociality, in improving HRQoL in schizophrenia.
摘要：
关于阴性症状（NS）维度与健康相关生活质量（HRQoL）关联的证据有限，并且之前没有研究研究NS域对HRQoL的贡献。本研究通过检查NS的关联来弥合差距，它的两个维度(动机和快乐，和情绪表现力)和五个领域(Anhedonia，个人行为,非社会性,精神分裂症患者的HRQoL伴弱视和Alogia）。对274例精神分裂症患者进行了阳性和阴性症状量表（PANSS）和简短阴性症状量表（BNSS）评估。使用先前在新加坡验证的算法，将PANSS分数映射到EuroQol五维（EQ-5D-5L）效用分数，所得EQ-5D-5L评分用作HRQoL的量度。对EQ-5D-5L的两个NS维度和五个NS域的多元线性回归分析显示，NS的严重程度较低，特别是动机和快乐(MAP)维度和有效性领域与较高的HRQoL相关。我们的发现强调了靶向NS的重要性，特别是MAP和社交，改善精神分裂症患者的HRQoL。
