目的:探讨茶、咖啡,和咖啡因的消费和女性不孕的风险。
方法:我们分析了2099名18至44岁女性的数据,参加2013-2018年国家健康和营养检查调查(NHANES)。我们使用广义线性模型(GLM)和广义加性模型(GAM)来研究茶,咖啡,咖啡因摄入和不孕症,调整潜在的混杂因素。
结果:在饮茶和不孕症之间检测到非线性关系,拐点为2杯/天。在拐点的右侧,我们没有发现显著的相关性.然而,在左边,我们发现饮茶与不孕症之间存在负相关关系(OR:0.73;95%CI:0.57至0.93;P=0.0122)。同时,我们的研究发现,咖啡(0.96,0.81~1.13,P=0.6189)或咖啡因摄入量(1.15,0.93~1.42,P=0.2148)与女性不孕症之间无显著关联.
结论:茶消费与不孕症呈非线性相关,而咖啡之间没有发现显著的关联,咖啡因消费和不孕。
OBJECTIVE: To explore the association between tea, coffee, and caffeine consumption and the risk of female infertility.
METHODS: We analyzed data from 2099 females aged 18 to 44 years, participating in the National Health and Nutrition Examination Survey (NHANES) 2013-2018. We used generalized linear models (GLM) and generalized additive model (GAM) to investigate the dose-response relationship between the tea, coffee, and caffeine consumption and infertility, adjusting for potential confounders.
RESULTS: A non-linear relationship was detected between tea consumption and infertility and the inflection point was 2 cups/day. On the right side of the inflection point, we did not detect a significant association. However, on the left side, we found a negative relationship between tea consumption and infertility (OR: 0.73; 95% CI: 0.57 to 0.93; P = 0.0122). Meanwhile, our study found no significant association between coffee (0.96, 0.81 to 1.13, P = 0.6189) or caffeine consumption (1.15, 0.93 to 1.42, P = 0.2148) and female infertility.
CONCLUSIONS: Tea consumption was non-linearly associated with infertility, whereas no significant associations were found between coffee, caffeine consumption and infertility.