Abstract：
OBJECTIVE: The association between tea consumption and kidney stones is inconsistent in observational studies. Thus, we performed a dose-response meta-analysis of prospective cohort studies and a two-sample Mendelian randomization (MR) analysis to identify this association.
METHODS: The prospective cohort studies reporting the relationship between tea consumption and kidney stones were searched from PubMed, the Cochrane Library, EMBASE, and Web of Science from inception to December 1, 2023. For MR analysis, the summary-level data for tea consumption and kidney stones were extracted from the UK Biobank available data and the 8th release of the FinnGen consortium, respectively. The inverse-variance weighted (IVW) method was the primary analytical method.
RESULTS: In our dose-response meta-analysis, four prospective cohort studies involving 1,263,008 participants were included, and tea consumption was found to have significant associations with kidney stones (RR: 0.80, 95% CI: 0.73-0.87). We also observed a substantially linear negative relationship between tea consumption and the risk of kidney stones. In MR analysis, the IVW method indicated that tea consumption was inversely associated with kidney stones (OR: 0.71, 95% CI: 0.53-0.94).
CONCLUSIONS: Our study confirmed a causal relationship between tea consumption and kidney stones, and higher tea consumption may reduce the risk of kidney stones.
METHODS: The prospective cohort studies reporting the relationship between tea consumption and kidney stones were searched from PubMed, the Cochrane Library, EMBASE, and Web of Science from inception to December 1, 2023. For MR analysis, the summary-level data for tea consumption and kidney stones were extracted from the UK Biobank available data and the 8th release of the FinnGen consortium, respectively. The inverse-variance weighted (IVW) method was the primary analytical method.
RESULTS: In our dose-response meta-analysis, four prospective cohort studies involving 1,263,008 participants were included, and tea consumption was found to have significant associations with kidney stones (RR: 0.80, 95% CI: 0.73-0.87). We also observed a substantially linear negative relationship between tea consumption and the risk of kidney stones. In MR analysis, the IVW method indicated that tea consumption was inversely associated with kidney stones (OR: 0.71, 95% CI: 0.53-0.94).
CONCLUSIONS: Our study confirmed a causal relationship between tea consumption and kidney stones, and higher tea consumption may reduce the risk of kidney stones.
摘要：
目的：在观察性研究中，饮茶与肾结石之间的关系不一致。因此，我们对前瞻性队列研究进行了剂量-反应荟萃分析,并进行了双样本孟德尔随机化(MR)分析,以确定这种关联.
方法：从PubMed搜索了报告茶消费与肾结石之间关系的前瞻性队列研究，Cochrane图书馆,EMBASE,和WebofScience从成立到2023年12月1日。对于MR分析，茶叶消费和肾结石的汇总数据是从英国生物银行现有数据和FinnGen联盟的第8次发布中提取的，分别。逆方差加权(IVW)方法是主要的分析方法。
结果：在我们的剂量反应荟萃分析中，纳入了四项前瞻性队列研究，涉及1,263,008名参与者，发现饮茶与肾结石有显著关联(RR:0.80,95%CI:0.73-0.87)。我们还观察到饮茶量与肾结石风险之间呈线性负相关。在MR分析中，IVW方法显示饮茶量与肾结石呈负相关(OR:0.71,95%CI:0.53-0.94).
结论：我们的研究证实了饮茶与肾结石之间的因果关系。和更多的茶消费可能会降低肾结石的风险。
方法：从PubMed搜索了报告茶消费与肾结石之间关系的前瞻性队列研究，Cochrane图书馆,EMBASE,和WebofScience从成立到2023年12月1日。对于MR分析，茶叶消费和肾结石的汇总数据是从英国生物银行现有数据和FinnGen联盟的第8次发布中提取的，分别。逆方差加权(IVW)方法是主要的分析方法。
结果：在我们的剂量反应荟萃分析中，纳入了四项前瞻性队列研究，涉及1,263,008名参与者，发现饮茶与肾结石有显著关联(RR:0.80,95%CI:0.73-0.87)。我们还观察到饮茶量与肾结石风险之间呈线性负相关。在MR分析中，IVW方法显示饮茶量与肾结石呈负相关(OR:0.71,95%CI:0.53-0.94).
结论：我们的研究证实了饮茶与肾结石之间的因果关系。和更多的茶消费可能会降低肾结石的风险。
