背景:先前的研究报道了习惯性饮茶与心血管疾病(CVD)风险之间因果关系的不一致结果。这项研究的目的是使用两个样本孟德尔随机(MR)分析来确定习惯性茶摄入量与CVD之间的关联。方法:茶消费与7种常见心血管疾病(心房颤动,高血压,急性心肌梗死,冠状动脉粥样硬化,外周血管疾病,心绞痛,和心力衰竭)使用MR分析模型进行评估。我们共进行了9种MR分析方法来分析最终结果。IVW方法被用作主要结果。另一种MR分析方法(简单模式,加权模式,简单中位数,加权中位数,惩罚加权中位数,Egger先生,和MR-Egger(bootstrap)作为IVW的补充。此外,使用留一法分析评估MR分析结果的稳健性.结果:IVW分析方法表明,饮茶与CVD风险之间没有因果关系(AF:OR,0.997,95%CI,0.992-1.0001,p=0.142;高血压:OR,0.976,95%CI,0.937-1.017,p=0.242;AMI:OR,0.996,95%CI,0.991-1.000,p=0.077;CA:OR,1.001,95%CI,0.993-1.009,p=0.854;PVD:OR,1.002,95%CI,1.000-1.005,p=0.096;心绞痛:OR,0.999,95%CI,0.993-1.006,p=0.818;HF:OR,0.999,95%CI,0.996-1.002,p=0.338)。另一种MR分析方法和进一步的留一法敏感性分析表明,结果是可靠的。结论:这项MR研究表明,习惯性茶摄入量与CVD风险之间没有遗传预测的因果关系。
Background: Previous studies have reported inconsistent results on the causal association between habitual tea consumption and the risk of cardiovascular disease (CVD). This study is aim to determine the association between habitual tea intake and CVD using two-sample Mendelian randomization (MR) analysis. Methods: The genetically predicted causation between tea consumption and 7 common cardiovascular diseases (atrial fibrillation, hypertension, acute myocardial infarction, coronary atherosclerosis, peripheral vascular disease, angina, and heart failure) was evaluated using MR analysis model. We performed a total of 9 MR analysis methods to analyze the final results. The IVW methods was used as the primary outcome. The other MR analysis method (simple mode, weighted mode, simple median, weighted median, penalized weighted median, MR Egger, and MR-Egger (bootstrap)) were performed as the complement to IVW. Also, the robustness of the MR analysis results was assessed using a leave-one-out analysis. Results: The IVW analysis methods indicated that there is no causal association between tea consumption and risk of CVD (AF: OR, 0.997, 95% CI, 0.992-1.0001, p = 0.142; hypertension: OR, 0.976, 95% CI, 0.937-1.017, p = 0.242; AMI: OR, 0.996, 95% CI, 0.991-1.000, p = 0.077; CA: OR, 1.001, 95% CI, 0.993-1.009, p = 0.854; PVD: OR, 1.002, 95% CI, 1.000-1.005, p = 0.096; angina: OR, 0.999, 95% CI, 0.993-1.006, p = 0.818; HF: OR, 0.999, 95% CI, 0.996-1.002, p = 0.338). The other MR analysis method and further leave-one-out sensitivity analysis suggested the results were robust. Conclusion: This MR study indicated that there was no genetically predicted causal association between habitual tea intake and risk of CVD.