PDF(Pubmed)
Abstract：
BACKGROUND: Numerous studies have reported the association between tea intake and lung diseases. However, the probable relationship between tea consumption on lung diseases still remain controversial and it is unclear whether these findings are due to reverse causality or confounding factor.
METHODS: In order to systematically investigate the causal connection between tea intake on respiratory system disorders, we employed a two-sample Mendelian randomized (MR) study. Genetic instruments for tea intake were identified from a genome-wide association study (GWAS) involving 447,385 individuals. Data on lung diseases were collected from a variety of publicly available genome-wide association studies. The main method used for MR analysis is the inverse variance weighting (IVW) method. To ensure the accuracy of the findings, further sensitivity analysis was conducted.
RESULTS: The IVW method in our MR analysis revealed no evidence to support a causal relationship between tea intake and lung diseases (IPF: OR = 0.997, 95% CI = 0.994-1.000, p = 0.065; Lung cancer: OR = 1.003, 95% CI = 0.998-1.008, P = 0.261; COPD: OR = 1.001, 95% CI = 0.993-1.006, p = 0.552; acute bronchitis: OR = 0.919, 95% CI = 0.536-1.576, p = 0.759; tuberculosis: OR = 1.002, 95% CI = 0.998-1.008, p = 0.301; pneumonia: OR = 0.789, 95% CI = 0.583-1.068, p = 0.125). The reliability of the results was further demonstrated by four additional MR analysis techniques and additional sensitivity testing.
CONCLUSIONS: We found no evidence of a link between tea intake on lung diseases in our MR results based on genetic information.
METHODS: In order to systematically investigate the causal connection between tea intake on respiratory system disorders, we employed a two-sample Mendelian randomized (MR) study. Genetic instruments for tea intake were identified from a genome-wide association study (GWAS) involving 447,385 individuals. Data on lung diseases were collected from a variety of publicly available genome-wide association studies. The main method used for MR analysis is the inverse variance weighting (IVW) method. To ensure the accuracy of the findings, further sensitivity analysis was conducted.
RESULTS: The IVW method in our MR analysis revealed no evidence to support a causal relationship between tea intake and lung diseases (IPF: OR = 0.997, 95% CI = 0.994-1.000, p = 0.065; Lung cancer: OR = 1.003, 95% CI = 0.998-1.008, P = 0.261; COPD: OR = 1.001, 95% CI = 0.993-1.006, p = 0.552; acute bronchitis: OR = 0.919, 95% CI = 0.536-1.576, p = 0.759; tuberculosis: OR = 1.002, 95% CI = 0.998-1.008, p = 0.301; pneumonia: OR = 0.789, 95% CI = 0.583-1.068, p = 0.125). The reliability of the results was further demonstrated by four additional MR analysis techniques and additional sensitivity testing.
CONCLUSIONS: We found no evidence of a link between tea intake on lung diseases in our MR results based on genetic information.
摘要：
背景：大量研究报道了茶摄入量与肺部疾病之间的关联。然而,饮茶与肺部疾病之间的可能关系仍存在争议，目前尚不清楚这些发现是由于反向因果关系还是混杂因素。
方法：为了系统地研究茶叶摄入对呼吸系统疾病的因果关系，我们采用了孟德尔随机(MR)双样本研究.从涉及447,385名个体的全基因组关联研究（GWAS）中鉴定了用于茶摄入的遗传工具。肺部疾病的数据是从各种公开的全基因组关联研究中收集的。用于MR分析的主要方法是方差逆加权(IVW)方法。为了确保调查结果的准确性，进行了进一步的敏感性分析.
结果：我们的MR分析中的IVW方法显示，没有证据支持茶摄入量与肺部疾病之间的因果关系（IPF：OR=0.997，95％CI=0.994-1.000，p=0.065；肺癌：OR=1.003，95％CI=0.998-1.008，P=0.261；COPD：OR=1.001，95％CI=0.50.0.0.0.5通过四种额外的MR分析技术和额外的灵敏度测试进一步证明了结果的可靠性。
结论：在基于遗传信息的MR结果中，我们没有发现茶摄入量与肺部疾病之间存在联系的证据。
方法：为了系统地研究茶叶摄入对呼吸系统疾病的因果关系，我们采用了孟德尔随机(MR)双样本研究.从涉及447,385名个体的全基因组关联研究（GWAS）中鉴定了用于茶摄入的遗传工具。肺部疾病的数据是从各种公开的全基因组关联研究中收集的。用于MR分析的主要方法是方差逆加权(IVW)方法。为了确保调查结果的准确性，进行了进一步的敏感性分析.
结果：我们的MR分析中的IVW方法显示，没有证据支持茶摄入量与肺部疾病之间的因果关系（IPF：OR=0.997，95％CI=0.994-1.000，p=0.065；肺癌：OR=1.003，95％CI=0.998-1.008，P=0.261；COPD：OR=1.001，95％CI=0.50.0.0.0.5通过四种额外的MR分析技术和额外的灵敏度测试进一步证明了结果的可靠性。
结论：在基于遗传信息的MR结果中，我们没有发现茶摄入量与肺部疾病之间存在联系的证据。
