Seniors

老年人
  • 文章类型: Journal Article
    尽管第三年龄大学(UTA)在老年人中越来越受欢迎,但没有很多可用的研究来研究所进行的教育活动对老年人坚持健康促进活动的影响。这项研究的目的是比较健康行为(例如,:身体活动,饮食习惯,酒精消费,吸烟,预防性测试表现)在参加和不参加UTA课程的老年人之间。
    该研究涉及631名(100%)60-92岁(x=70.28±6.09岁)的老年人。研究组大多数为女性(475;75.28%)。为了进行研究,使用了专有的问卷,由有关讨论主题的问题和基本问题组成,包括:年龄,性别,居住和教育的地方。波兰语版本的标准化问卷-“我的饮食行为”检查受访者的饮食行为。Chi2检验用于定性数据,对于定量数据-Mann-WhitneyU检验(无正态分布:TS-W<0.001)。使用线性和逻辑回归模型来检查在调整潜在的联合创始人后是否会保持关联。统计显著性水平设定为α<0.05。
    参与UTA活动的老年人数量较高:积极花费空闲时间(261;73.73%vs.93;26.27%;p<0.001),定期体力活动(270;76.27%vs.133;48.01%;p<0.001),身体活动的自我评估(259;73.16%vs.95;26.84%;p=0.004),体力活动的持续时间(<0.001),过去吸烟(133;37.57vs.76;27.44%;p=0.007)和饮酒取决于习惯频率(p<0.001)。未参加UTA课程的老年人数量在以下方面较低:定期年度牙科控制(161;58.12%;265;74.86%;p<0.001),乳房/睾丸定期自我检查(148;53.43%vs.218;61.58%;p=0.04)和常规实验室测试(232;83.75%vs.318;89.83%;p=0.02)。
    在UTA上课的老年人的健康促进行为在体育锻炼方面更为正确,充分参加预防性测试,酒精消费最差。总体情况可以得出结论,参加UTA课程似乎对接受调查的老年人的健康促进行为产生了积极影响。
    UNASSIGNED: Regardless of the fact that Universities of Third Age (UTA\'s) are becoming more and more popular among seniors there are not many available studies examining the impact of conducted educational activities on seniors\' adherence to health-promoting activities. The aim of the study was to compare health behaviors (e.g.,: physical activity, eating habits, alcohol consumption, tobacco smoking, preventive tests performance) between seniors attending and not attending UTA\'s classes.
    UNASSIGNED: The study involved 631 (100%) seniors aged 60-92 years (x =70.28 ± 6.09 years). The majority of the study group were women (475; 75.28%). To conduct the study, a proprietary questionnaire was used, consisting of questions regarding the discussed topic and basic questions including: age, gender, place of residence and education. Polish versions of standardized questionnaire-\"My eating behaviors\" examine eating behaviors of the respondents. The Chi2 test was used for qualitative data, and for quantitative data-the Mann-Whitney U test (No normal distribution: T S-W < 0.001). Linear and logistic regression models were used to check whether the associations would remain after adjustments for potential cofounders. The level of statistical significance was set at α < 0.05.
    UNASSIGNED: Number of seniors participating in UTA\'s activities was higher in terms of engaging in: actively spending free time (261; 73.73% vs. 93; 26.27%; p < 0.001), regular physical activity (270; 76.27% vs. 133; 48.01%; p < 0.001), self-assessment of physical activity (259; 73.16% vs. 95; 26.84%; p = 0.004), duration of physical activity (< 0.001), past tobacco smoking (133; 37.57 vs. 76; 27.44%; p = 0.007) and alcohol consumption depending on the habit frequency (p < 0.001). Number of seniors not participating in UTA\'s classes was lower in terms of: regular annual dental controls (161; 58.12%; vs. 265; 74.86%; p < 0.001), regular self-examination of breasts/testicles (148; 53.43% vs. 218; 61.58%; p = 0.04) and regular laboratory tests (232; 83.75% vs. 318; 89.83%; p = 0.02).
    UNASSIGNED: Health-promoting behaviors of seniors attending classes at the UTA\'s were more correct in terms of physical activity, adequate attendance with preventive test and worst in terms of alcohol consumption. Overall picture allows to conclude that participation in UTA\'s classes seems to have a positive impact on the examined health-promoting behaviors of the surveyed seniors.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    无家可归的老年人在心理健康需求和服务获取方面面临着不同的挑战。这项研究旨在通过检查精神疾病的患病率来阐明无家可归的老年人的心理健康景观,利用精神卫生服务,以及对精神保健的感知需求。这项研究包括纽约的177名无家可归的老年人,NY.研究结果表明,10.2%的人患有抑郁症,10.2%精神分裂症,和5.7%的双相情感障碍。尽管患病率很高,诊断出的精神健康状况和服务利用率之间存在显着差距,只有50%的抑郁症患者寻求治疗。对精神卫生服务的感知需求是这项研究的一个关键方面,超过一半的人患有抑郁症(61.1%;n=11),PTSD(75%;n=3),精神分裂症(77.8%;n=14),和其他精神疾病(100%;n=1)表示需要精神保健。此外,心理健康状况,孤独,社会支持水平在精神卫生服务需求中起着重要作用。
    Homeless seniors confront distinct challenges regarding their mental health needs and service access. This study aims to illuminate the mental health landscape of homeless seniors by examining the prevalence of mental illness, utilization of mental health services, and perceived need for mental health care. The study comprises 177 homeless seniors in New York, NY. Findings indicate 10.2% experiencing depression, 10.2% schizophrenia, and 5.7% bipolar disorder. Despite high prevalence, there is a significant gap between diagnosed mental health conditions and service utilization, with only 50% of those with depression seeking care. Perceived need for mental health services emerges as a critical aspect of the study, with over half of those suffering from depression (61.1%; n = 11), PTSD (75%; n = 3), schizophrenia (77.8%; n = 14), and other mental illnesses (100%; n = 1) expressing a need for mental health care. Also, mental health conditions, loneliness, and levels of social support play significant roles in a need for mental health services.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    目的:ESPEN和EASO最近制定了关于节育性肥胖(SO)的共识标准,采用骨骼肌质量与重量(SMM/W)的比率。新的证据表明,根据体重指数(SMM/BMI)调整骨骼肌质量可以提高健康结果的预测准确性。我们旨在验证ESPEN/EASO标准,并探讨SMM/BMI调整在预测中国西部老年人跌倒中的潜在益处。
    方法:我们进行了多中心,横断面研究,包括社区居住的老年人。使用标准的ESPEN/EASO共识标准(SOESPEN)和调整SMM/BMI的修改版本(SOESPEN-M)确定SO的诊断。SOESPEN协会,SOESPEN-M,并分析了它们与跌倒的成分。
    结果:在1353名参与者中,SO的患病率为13.2%(SOESPEN)和11.4%(SOESPEN-M),随着年龄和较高的BMI水平而增加。在BMI正常的参与者中,4.2%和6.2%被发现有SOESPEN和SOESPEN-M,分别。SMM/W和SMM/BMI与跌倒风险呈负相关(分别为p=0.042和p=0.021)。在调整混杂因素后,只有SOESPEN与跌倒显着相关(优势比[OR]1.61,95%置信区间[CI]1.08至2.40),而SOESPEN-M的关联没有达到显著性(OR1.55,95%CI0.99~2.43).
    结论:这项研究在中国西部社区居住的老年人中验证了ESPEN/EASO标准(SOESPEN)及其修改版本(SOESPEN-M)。SMM/BMI调整似乎提供了对SO患病率的较低估计,只有SOESPEN显示与跌倒有显著关联。
    OBJECTIVE: The ESPEN and the EASO recently developed consensus criteria for sarcopenic obesity (SO), employing the skeletal muscle mass to weight (SMM/W) ratio. Emerging evidence suggests that adjusting skeletal muscle mass for body mass index (SMM/BMI) could enhance the predictive accuracy for health outcomes. We aimed to validate the ESPEN/EASO criteria and explore the potential benefits of the SMM/BMI adjustment in predicting falls among older adults in Western China.
    METHODS: We conducted a multicenter, cross-sectional study and included community-dwelling older adults. The diagnosis of SO was determined using the standard ESPEN/EASO consensus criteria (SOESPEN) and a modified version adjusting SMM/BMI (SOESPEN-M). The associations of SOESPEN, SOESPEN-M, and their components with falls were analyzed.
    RESULTS: Among the 1353 participants, the prevalence of SO was 13.2 % (SOESPEN) and 11.4 % (SOESPEN-M), which increased with age and higher BMI levels. Within participants with a normal BMI, 4.2 % and 6.2 % were found to have SOESPEN and SOESPEN-M, respectively. SMM/W and SMM/BMI negatively correlated with fall risk (p=0.042 and p=0.021, respectively). Upon adjusting for confounders, only SOESPEN was significantly associated with falls (odds ratios [OR] 1.61, 95 % confidence interval [CI] 1.08 to 2.40), whereas the association for SOESPEN-M did not achieve significance (OR 1.55, 95 % CI 0.99 to 2.43).
    CONCLUSIONS: This research validated the ESPEN/EASO criteria (SOESPEN) and their modified version (SOESPEN-M) among community-dwelling older adults in Western China. The SMM/BMI adjustment appears to offer a lower estimate of SO prevalence, with only SOESPEN showing a significant association with falls.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    尽管许多研究已经调查了社区居住的老年人中轻度认知障碍(MCI)的可改变的危险因素,没有荟萃分析总结了这些发现.从2000年1月1日至2023年12月30日搜索了五个数据库。该协议已在PROSPERO注册。根据系统评价和荟萃分析指南的首选报告项目提取和报告数据。对可改变的危险因素进行相关荟萃分析。通过队列研究的GRADE评估每个因素的证据。在16,651次引用中,包括87项研究,涉及225,584名社区居住老年人。进行了14项荟萃分析,涉及20项研究,共44,199名参与者。分析显示,低到中等质量的证据支持糖尿病,2或更多合并症,焦虑,冷漠,抑郁症状,和身体虚弱是老年人发生MCI的危险因素.相反,高血压,激动,易怒可能不是危险因素。此外,中等质量的证据支持参与认知需求活动对MCI发病的保护作用.总的来说,这项研究是关于老年人MCI发展的各种危险因素的首次广泛证据汇编.我们的发现对于指导制定预防和管理策略以预防或可能逆转MCI的发作具有重要的潜力。
    Although numerous studies have investigated modifiable risk factors for mild cognitive impairment (MCI) among community-dwelling seniors, no meta-analysis has summarized these findings. Five databases were searched from January 1, 2000, to December 30, 2023. The protocol was registered with PROSPERO. Data were extracted and reported following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant meta-analyses of modifiable risk factors were performed. The evidence of each factor was assessed by the GRADE for cohort studies. Of 16,651 citations, 87 studies involving 225,584 community-dwelling seniors were included. Fourteen meta-analyses involving 20 studies with 44,199 participants were performed. The analyses revealed low-to-moderate-quality evidence supporting that diabetes, 2 or more comorbidities, anxiety, apathy, depressive symptoms, and physical frailty were risk factors for incident MCI in older adults. Conversely, hypertension, agitation, and irritability might not be risk factors. Additionally, moderate-quality evidence supports the protective effect of engaging in cognitive-demanding activities on the onset of MCI. Collectively, this study constitutes the first extensive compilation of evidence regarding the various risk factors for the development of MCI in older adults. Our findings hold significant potential to guide the formulation of prevention and management strategies to either prevent or potentially reverse the onset of MCI.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: English Abstract
    BACKGROUND: Taking into account the multi-directional beneficial effects of vitamin D3 and its widespread deficiency, regular supplementation is recommended. However, more and more attention is being paid to the risk of overdose with supplemented vitamin D3 and the associated serious health consequences.
    METHODS: The concentration of 25-hydroxyvitamin D (25(OH)D) is a routine test recommended upon admission to the Geriatrics Clinic of Wroclaw Medical University. The aim of the study was to analyze the results from January 2018 to June 2023. Additionally, information on the reported symptoms, gender and age of people with an increased level of vitamin D3 was collected.
    RESULTS: Analyzing a group of 1400 patients, it was noted that within 5 years, vitamin D3 concentrations exceeding the recommended level were recorded in 7 patients, including 3 with toxic levels. All abnormal results occurred in women. The most frequently reported symptoms included general weakness, lower limbs and joint pain, sleep disorders, low mood. People with toxic concentrations reported dizziness. In seniors there is a gradual increase in vitamin D concentration and its deficiency is less common. Higher concentrations were recorded in the group of older seniors, and concentrations considered toxic occur in the population >74 years of age. Supplements and drugs with vitamin D are most often used without consulting a doctor, without determining the appropriate dose, or without assessing the concentration of 25(OH)D in the serum.
    CONCLUSIONS: To prevent vitamin D deficiency in seniors, doses >4000 IU daily are not recommended. It is advisable to check all medications and supplements taken at each doctor\'s visit in terms of duplicating treatment with vitamin D. It is advisable to assess the status of vitamin D supply the concentration of 25(OH)D in order to select the appropriate dose. Assessment of 1,25-dihydroxyvitamin D concentration is recommended in cases of vitamin D toxicity. Med Pr Work Health Saf. 2024;75(3).
    UNASSIGNED: Biorąc pod uwagę wielokierunkowe korzystne działanie witaminy D3 i jej rozpowszechniony niedobór także w populacji polskiej, powszechnie zaleca się jej regularną suplementację. Coraz więcej uwagi zwraca się jednak na ryzyko przedawkowania suplementowanej witaminy D3 i związane z tym poważne skutki zdrowotne.
    UNASSIGNED: Kontrola stężenia 25-hydroksywitaminy D (25(OH)D) jest rutynowym badaniem zalecanym przy przyjęciu do Kliniki Geriatrii Uniwersytetu Medycznego we Wrocławiu. Celem pracy była analiza uzyskanych wyników w okresie od stycznia 2018 r. do czerwca 2023 r. Dodatkowo zebrano informacje odnośnie do zgłaszanych objawów, płci i wieku osób ze stwierdzonym podwyższonym stężeniem witaminy D3.
    UNASSIGNED: Analizując grupę 1400 pacjentów, odnotowano, że w ciągu 5 lat wartości przekraczające zalecane stężenia witaminy D3 odnotowano u 7 pacjentów, w tym u 3 był to poziom toksyczny. Wszystkie nieprawidłowe wyniki dotyczyły kobiet. W analizowanej populacji wśród najczęściej zgłaszanych objawów dominowały skargi na ogólne osłabienie, bóle kończyn dolnych, bóle stawów, zaburzenia snu i obniżenie nastroju. Dodatkowo osoby ze stężeniem toksycznym zgłaszały zawroty głowy. Analiza wykazała, że w populacji geriatrycznej obserwuje się stopniowy wzrost stężenia witaminy D i rzadziej występuje jej niedobór. Wyższe i toksyczne stężenia odnotowano u pacjentów >74 r.ż. Suplementy i leki z witaminą D są najczęściej stosowane bez konsultacji z lekarzem, bez ustalenia właściwej dawki i bez oceny stężenia 25(OH)D w surowicy.
    UNASSIGNED: W prewencji niedoboru witaminy D u osób >65 r.ż. nie należy stosować dawek >4000 j.m./d. Wskazana jest ocena wszystkich przyjmowanych przez seniorów leków i suplementów diety przy każdej wizycie lekarskiej pod względem powielania leczenia także witaminą D. W populacji osób starszych wskazana jest ocena stanu zaopatrzenia w witaminę D poprzez oznaczenia stężenia 25(OH)D w celu doboru właściwej dawki i korekty suplementowania. Oznaczenie stężenia 1,25-dihydroksywitaminy D jest wskazane w przypadku zatrucia witaminą D w celu wykluczenia jej pozanerkowej hydroksylacji. Med Pr Work Health Saf. 2024;75(3).
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    暂无摘要。
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    本研究旨在:1)探索城市社区中步行速度慢(SSWS)的老年人的行动体验;和2)调查他们的环境障碍和支持。
    对居住在重庆市市区的36个SSWS进行了访谈,中国。通过制图分析和专题分析揭示了影响其流动性的流动模式和建筑环境因素。
    SSWS主要将活动集中在其房屋半径400米的范围内。建筑环境主题包括地形,邻里服务,人行道,座位,交通安全,天气,绿化,和照明。重要的行动障碍包括长楼梯,陡坡,人行道上快速移动的物体,十字路口,和快速的交通。可用的扶手,附近的餐饮服务场所,充足的座位,绿化被确定为其流动性的支持因素。
    这项研究是第一个专门检查SSWS在建筑环境中的移动性的研究。我们建议在为通用设计框架建立基准时应考虑SSWS。这些改进不仅有助于慢步行者的流动性,而且对更广泛的人口产生积极影响。
    UNASSIGNED: This study aims to: 1) Explore the mobility experiences of seniors with slow walking speeds (SSWS) in urban neighborhoods; and 2) Investigate their environmental barriers and supports.
    UNASSIGNED: Go-along interviews were conducted with 36 SSWS residing in urban neighborhoods of Chongqing City, China. The mobility patterns and built environment factors influencing their mobility were revealed through cartographic analysis and thematic analysis.
    UNASSIGNED: SSWS primarily focused their activities within a 400-meter radius of their homes. Built environment themes included topography, neighborhood services, sidewalks, seating, traffic safety, weather, greenery, and lighting. Significant mobility barriers included long stairs, steep slopes, fast-moving objects on sidewalks, road crossings, and fast traffic. Available handrails, nearby food-service places, ample seating, and greenery were identified as supportive factors for their mobility.
    UNASSIGNED: This study stands out as the first to specifically examine the mobility of SSWS within the built environment. We suggest that SSWS should be taken into account when establishing a benchmark for general design frameworks. These improvements not only contribute to the mobility of slow walkers but also have positive impacts on the broader population.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:建筑法规确定设计建筑环境,以识别不同年龄和心理物理能力的用户的需求。老年人及其空间需求在那里得到了有限的覆盖。设计的基准是轮椅使用者。与独立步行者相比,它们的空间要求更高,包括大多数老年人。这使得难以使整个建筑环境适应行动不便较少的人的需求。这可以从空间设计和投资成本的角度来考虑。
    方法:本文从法律条件方面分析了3个国家的建筑法规,以塑造老年人和残疾人的建筑运动空间。使用分析和比较方法。这种研究变得有意义和必要。这些分析是在人口老龄化的背景下进行的。波兰社会年龄组的统计数据证明了这一点。接下来是对轮椅运动空间的法律要求的设计分析和替代方案的建议,例如,人们用手杖走路(案例研究)。他们的目的是指出限制建筑物中过度通信空间的方法,同时保持所有用户的功能价值。
    结果:研究可能表明法规和替代现行法律的更大多样化的可能性。他们致力于参与投资过程,以塑造无障碍建筑。它们也可以用于建筑法修正案的立法工作。
    结论:提出了建筑法规的变化以及针对老年人和残疾人(独立行走)的行动需求的详细方法。这些决策可以带来好处(节省空间和经济)。它们属于建筑环境的“所有人的设计”趋势和可持续性。这些要求基于不再有效的规范性法规。MedPr工作健康Saf。2024;75(3)。
    BACKGROUND: Building law regulations determine designing the built environment recognising the needs of users of different ages and psychophysical abilities. Seniors and their spatial needs are covered there to a limited extent. The benchmark for design are wheelchair users. Their spatial requirements are greater in relation to independent walkers, including most older people. This makes it difficult to adapt the whole built environment to the needs of people with less mobility dysfunction. This can be considered in terms of spatial design and investment costs.
    METHODS: The paper analyses the building regulations of 3 countries in terms of legal conditions to shape the architectural movement space of older people and disabled people. Analytical and comparative methods are used. Such research is becoming relevant and necessary. The analyses are conducted in the context of ageing populations. They are justified by statistical data on the age groups of Polish society. This is followed by design analyses of the legal requirements in the wheelchair movement space and proposals for alternatives, e.g., people walking with canes (case study). Their aim is to indicate methods to limit excessive communication spaces in buildings while maintaining functional values for all users.
    RESULTS: Research may show the possibility of greater diversification of regulations and alternatives to current laws. They are dedicated to participants in investment processes to shape accessible buildings. They can also be used in legislative work on amendments to the construction law.
    CONCLUSIONS: Changes in building regulations and a detailed approach to the mobility needs of older and disabled people (walking independently) are proposed. These decisions can provide benefits (spatial and economic savings). They fall into the \"design for all\" trend and sustainability of the built environment. These demands are based on no longer valid normative regulations. Med Pr Work Health Saf. 2024;75(3):189-197.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    大约三分之二因跌倒而被送往急诊科(ED)的患者在没有紧急治疗的情况下从急诊室出院。这项试点研究测试了实施由紧急医疗技术人员(EMT)执行的院前跌倒评估协议的可行性,以确定跌倒的患者是否需要ED评估或可以安全地转诊到社区资源。
    该方案由受过训练的EMT在2019年10月至2020年3月在舍布鲁克(QC)跌倒后对≥65岁的成年人进行管理。无论方案结果如何,所有患者均被转运至ED(推荐/不推荐转运)。目的是评估EMT是否可以完成协议,并就运输到ED做出适当的决定。次要目标旨在评估识别不需要运输的患者的准确性。并测量对可避免的救护车运输的影响。
    总共进行了125例EMT干预:17例患者属于不推荐运输组,占到医院与跌倒相关的EMT呼叫的14%,这是可以避免的。其中,110人被运送到ED。现场EMT干预的平均持续时间为31分钟。四十七名病人入院,主要是感染和骨折,包括不推荐运输组中的四个。
    这项研究表明,EMT可以实施跌倒评估方案,旨在识别需要进行ED评估的患者。结果允许在评估方案安全性的项目第二阶段之前修改方案。
    UNASSIGNED: Approximately two-thirds of patients transported to emergency departments (ED) for a fall are discharged from the ED without urgent treatment. This pilot study tests the feasibility of implementing a pre-hospital falls-assessment protocol performed by emergency medical technicians (EMTs) to determine whether a patient who fell needs an ED assessment or could be referred safely to a community resource.
    UNASSIGNED: The protocol was administered by trained EMTs to adults aged ≥ 65 after a fall between October 2019 and March 2020 in Sherbrooke (QC). All patients were transported to ED regardless of protocol outcome (transport recommended/not recommended). The objective was to assess if EMTs could complete the protocol and make the appropriate decision concerning the transport to ED. Secondary objectives aimed to assess the accuracy in identifying patients who do not require transport, and to measure the impact on avoidable ambulance transports.
    UNASSIGNED: A total of 125 EMTs interventions were carried out: 17 patients were in the transport not recommended group, representing 14% of transport to hospital for falls-related EMTs calls that could be possibly avoided. Of these, 110 were transported to ED. Mean duration of on-site EMTs interventions was of 31 minutes. Forty-seven patients were admitted, mostly for infections and fractures, including four in the transport not recommended group.
    UNASSIGNED: This study showed that EMTs can administer a falls-assessment protocol aimed at identifying patients that need an ED evaluation. Results permitted to amend the protocol before the second phase of the project evaluating the safety of the protocol.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:老年人的酒精和物质使用正在增加,其中许多人患有抑郁症,在这种情况下的治疗可能更危险。我们评估了患有难治性抑郁症(TRD)的老年人的酒精和其他物质使用模式。我们研究了与高饮酒量相关的患者特征,并研究了酒精对抗抑郁治疗期间临床变量与跌倒之间关联的调节作用。
    方法:这项次要和探索性分析使用了基线临床数据和治疗期间跌倒的数据,这些数据来自一项针对患有TRD的老年人的大型随机抗抑郁试验(OPTIMUM试验)。使用多变量有序逻辑回归来识别与高级酒精使用相关的变量。使用相互作用模型来评估酒精对治疗期间跌倒的调节作用。
    结果:在687名参与者中,51%的人承认使用酒精:10%是危险饮酒者(AUDIT-10评分≥5),41%是低风险饮酒者(评分1-4)。24%的参与者和21%的饮酒者使用苯二氮卓类药物。使用其他物质(主要是大麻)与饮酒有关:5%,9%,15%的弃权者,低风险饮酒者,和危险的饮酒者,分别。出乎意料的是,使用其他药物仅在戒断者中在抗抑郁治疗期间可预测跌倒风险增加.
    结论:本研究中,有一半的TRD患者承认使用酒精。与苯二氮卓类药物和其他物质同时使用酒精是常见的。在抗抑郁治疗期间使用酒精和其他物质的风险-例如跌倒-需要进一步研究。
    BACKGROUND: Alcohol and substance use are increasing in older adults, many of whom have depression, and treatment in this context may be more hazardous. We assessed alcohol and other substance use patterns in older adults with treatment-resistant depression (TRD). We examined patient characteristics associated with higher alcohol consumption and examined the moderating effect of alcohol on the association between clinical variables and falls during antidepressant treatment.
    METHODS: This secondary and exploratory analysis used baseline clinical data and data on falls during treatment from a large randomized antidepressant trial in older adults with TRD (the OPTIMUM trial). Multivariable ordinal logistic regression was used to identify variables associated with higher alcohol use. An interaction model was used to evaluate the moderating effect of alcohol on falls during treatment.
    RESULTS: Of 687 participants, 51% acknowledged using alcohol: 10% were hazardous drinkers (AUDIT-10 score ≥5) and 41% were low-risk drinkers (score 1-4). Benzodiazepine use was seen in 24% of all participants and in 21% of drinkers. Use of other substances (mostly cannabis) was associated with alcohol consumption: it was seen in 5%, 9%, and 15% of abstainers, low-risk drinkers, and hazardous drinkers, respectively. Unexpectedly, use of other substances predicted increased risk of falls during antidepressant treatment only in abstainers.
    CONCLUSIONS: One-half of older adults with TRD in this study acknowledged using alcohol. Use of alcohol concurrent with benzodiazepine and other substances was common. Risks-such as falls-of using alcohol and other substances during antidepressant treatment needs further study.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

公众号