Seniors

老年人
  • 文章类型: Journal Article
    虽然经典阻力运动是提高力量和控制姿势摇摆的有效方法,它可能不适合一些患有特定健康障碍的老年人(例如,动脉瘤)。因此,有必要探索替代模式。该研究旨在评估感觉运动训练对女性老年人群肌肉力量和姿势控制的影响,并随后将这些影响与传统的抗耐力联合训练计划进行比较。共有34位健康人士,年龄在65至75岁之间的活跃老年妇女,(平均年龄72.7±4.4岁,高度161.6±5.1厘米,和体重66.9±8.4kg)被随机分配到接受不同的10周干预的三组:阻力-耐力训练(RET,n=11),感觉运动训练(SMT,n=12)和对照组(COG,n=11)。在干预之前和之后,所有参与者都接受了主要和非主要腿的最大自愿收缩测试;睁眼和闭眼的姿势摇摆测试;新颖的视觉反馈平衡测试;10米最大步行速度(10mMWS)和爬楼梯测试。使用T检验和重复测量方差分析,接下来是Bonferroni事后测试,比较前后的测量结果,并评估组间的增益差异。结果显示时间对强度有显著的主要影响(p<0.001)。此外,时间×群体交互作用在强度上有显著差异(p<0.01),姿势控制(p<01),观察到上升和下降的垂直速度(p<0.001)。此外,RET组显著提高了两种优势的最大自愿收缩(16.3%,p≤0.01)和非优势腿(10.9%,p≤0.05)。SMT组改善了两种优势的最大自愿收缩(16.6%,p≤0.001)和非优势腿(12.7%,p≤0.01)。此外,他们还提高了睁眼姿势摇摆试验中压力中心(COP)的平均速度(24.2%,p≤0.05)以及闭眼(29.2%,p≤0.05),新型视觉反馈平衡测试中COP的平均距离(37.5%,p≤0.001),上升和下降的垂直速度(13.6%,p≤0.001和17.8%,p≤0.001,分别)。结果表明,不仅阻力训练,而且感觉运动干预也可以增强力量。这种干预还增强了上升和下降运动的姿势控制和功能能力。
    While classical resistance exercise is an effective way to improve strength and control postural sway, it may not be suitable for some elderly individuals with specific health disorders (e.g., aneurysms). Therefore, there is a need to explore alternative modalities. The study aimed to evaluate the effects of sensorimotor training on muscle strength and postural control in the female elderly population and subsequently compare these effects with a traditional combined resistance-endurance training program. A total of 34 healthy, active elderly women aged from 65 to 75 years, (average age 72.7 ± 4.4 years, height 161.6 ± 5.1 cm, and weight 66.9 ± 8.4 kg) were randomly assigned to three groups undergoing different 10-week interventions: the resistance-endurance training (RET, n = 11), the sensorimotor training (SMT, n = 12) and the control group (COG, n = 11). Prior to and after the interventions all participants underwent tests of maximal voluntary contraction of the dominant and non-dominant leg; postural sway tests with open and closed eyes; novel visual feedback balance test; 10-meter maximal walking speed (10 mMWS) and stair climb test. A T-test and repeated measures ANOVA were used, followed by the Bonferroni post hoc test, to compare the pre and post-measurements and assess differences in gains between groups. Results showed a significant main effect of time on strength (p < 0.001). In addition, significant differences in time × group interaction on strength (p < 0.01), postural control (p < 01), and ascendant and descended vertical speed (p < 0.001) were observed. Besides, the RET group improved significantly the maximal voluntary contraction of both dominant (16.3%, p ≤ 0.01) and non-dominant leg (10.9%, p ≤ 0.05). SMT group improved maximal voluntary contraction of both dominant (16.6%, p ≤ 0.001) and non-dominant leg (12.7%, p ≤ 0.01). In addition, they also improved mean velocity of the centre of pressure (COP) in postural sway test with eyes open (24.2%, p ≤ 0.05) as well as eyes closed (29.2%, p ≤ 0.05), mean distance of COP in novel visual feedback balance test (37.5%, p ≤ 0.001), ascendant and descended vertical velocity (13.6%, p ≤ 0.001 and 17.8%, p ≤ 0.001, respectively). Results show not only resistance training but sensorimotor intervention boosts strength too. This intervention also enhances postural control and functional abilities for both ascending and descending movements.
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  • 文章类型: Journal Article
    老年人的髋部骨折通常会导致不良的健康结果,这可能与手术时间和住院时间有关。新不伦瑞克省老年人髋部骨折的经验尚不清楚。
    这是一项回顾性观察性研究。所有65岁及以上的髋部骨折患者于2015年4月1日至2019年3月31日期间入住一家指定为一级创伤中心的医院。
    大多数(86.5%)在48小时内接受了手术,超过此时间范围接受手术的患者在急性护理中的停留时间明显更长(OR:3.79,95%CI:2.05-7.15)。满足急性护理需求后出院患者的平均总住院时间(总住院时间)为9.8天(SD=8.1),而因非医疗原因而延迟出院的患者为26.3天(SD=33.7)。长期接受急性护理(OR:1.93,95%CI:1.09-3.43)和年龄增加(OR:1.03,95%CI:1.001-1.06)与出院后一年死亡的可能性更高相关。超过24小时的手术时间(OR:2.80,95%CI:1.13-7.38)与出院后30天死亡的可能性更高相关。
    大多数患者在少于48小时的国家基准范围内进行了手术。在满足急性护理需求后仍留在医院的患者的总LOS增加了2.5倍。更好地了解患者的特征,比如脆弱,可以更好地预测住院时间更长和健康结局不良的患者。
    UNASSIGNED: Hip fractures in older adults often lead to adverse health outcomes, which may be related to time to surgery and longer hospital stays. The experience of older adults with hip fractures in New Brunswick is not known.
    UNASSIGNED: This was a retrospective observational study. All hip fracture patients 65 years of age and older admitted to one hospital designated as a Level One Trauma Centre between April 1, 2015 and March 31, 2019 comprised the sample.
    UNASSIGNED: The majority (86.5%) received surgery within 48 hours and those who had surgery beyond this time frame had a significantly longer stay in acute care (OR: 3.79, 95% CI: 2.05-7.15). The mean total length of stay (Total-LOS) for patients discharged after their acute care needs were met was 9.8 days (SD=8.1) compared to patients experiencing delays in discharge for nonmedical reasons which was 26.3 days (SD=33.7). An extended stay in acute care (OR: 1.93, 95% CI: 1.09-3.43) and increasing age (OR: 1.03, 95% CI: 1.001-1.06) were associated with a higher likelihood of death at one year post-discharge. Time to surgery beyond 24 hours (OR: 2.80, 95% CI: 1.13-7.38) was associated with a higher likelihood of death 30 days post-discharge.
    UNASSIGNED: Most patients had surgery within the national benchmark of less than 48 hours. The Total-LOS increased 2.5-fold in patients who remained in hospital after their acute care needs were met. A better understanding of patient characteristics, such as frailty, may better predict patients at risk for longer hospital stays and adverse health outcomes.
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  • 文章类型: Journal Article
    尽管第三年龄大学(UTA)在老年人中越来越受欢迎,但没有很多可用的研究来研究所进行的教育活动对老年人坚持健康促进活动的影响。这项研究的目的是比较健康行为(例如,:身体活动,饮食习惯,酒精消费,吸烟,预防性测试表现)在参加和不参加UTA课程的老年人之间。
    该研究涉及631名(100%)60-92岁(x=70.28±6.09岁)的老年人。研究组大多数为女性(475;75.28%)。为了进行研究,使用了专有的问卷,由有关讨论主题的问题和基本问题组成,包括:年龄,性别,居住和教育的地方。波兰语版本的标准化问卷-“我的饮食行为”检查受访者的饮食行为。Chi2检验用于定性数据,对于定量数据-Mann-WhitneyU检验(无正态分布:TS-W<0.001)。使用线性和逻辑回归模型来检查在调整潜在的联合创始人后是否会保持关联。统计显著性水平设定为α<0.05。
    参与UTA活动的老年人数量较高:积极花费空闲时间(261;73.73%vs.93;26.27%;p<0.001),定期体力活动(270;76.27%vs.133;48.01%;p<0.001),身体活动的自我评估(259;73.16%vs.95;26.84%;p=0.004),体力活动的持续时间(<0.001),过去吸烟(133;37.57vs.76;27.44%;p=0.007)和饮酒取决于习惯频率(p<0.001)。未参加UTA课程的老年人数量在以下方面较低:定期年度牙科控制(161;58.12%;265;74.86%;p<0.001),乳房/睾丸定期自我检查(148;53.43%vs.218;61.58%;p=0.04)和常规实验室测试(232;83.75%vs.318;89.83%;p=0.02)。
    在UTA上课的老年人的健康促进行为在体育锻炼方面更为正确,充分参加预防性测试,酒精消费最差。总体情况可以得出结论,参加UTA课程似乎对接受调查的老年人的健康促进行为产生了积极影响。
    UNASSIGNED: Regardless of the fact that Universities of Third Age (UTA\'s) are becoming more and more popular among seniors there are not many available studies examining the impact of conducted educational activities on seniors\' adherence to health-promoting activities. The aim of the study was to compare health behaviors (e.g.,: physical activity, eating habits, alcohol consumption, tobacco smoking, preventive tests performance) between seniors attending and not attending UTA\'s classes.
    UNASSIGNED: The study involved 631 (100%) seniors aged 60-92 years (x =70.28 ± 6.09 years). The majority of the study group were women (475; 75.28%). To conduct the study, a proprietary questionnaire was used, consisting of questions regarding the discussed topic and basic questions including: age, gender, place of residence and education. Polish versions of standardized questionnaire-\"My eating behaviors\" examine eating behaviors of the respondents. The Chi2 test was used for qualitative data, and for quantitative data-the Mann-Whitney U test (No normal distribution: T S-W < 0.001). Linear and logistic regression models were used to check whether the associations would remain after adjustments for potential cofounders. The level of statistical significance was set at α < 0.05.
    UNASSIGNED: Number of seniors participating in UTA\'s activities was higher in terms of engaging in: actively spending free time (261; 73.73% vs. 93; 26.27%; p < 0.001), regular physical activity (270; 76.27% vs. 133; 48.01%; p < 0.001), self-assessment of physical activity (259; 73.16% vs. 95; 26.84%; p = 0.004), duration of physical activity (< 0.001), past tobacco smoking (133; 37.57 vs. 76; 27.44%; p = 0.007) and alcohol consumption depending on the habit frequency (p < 0.001). Number of seniors not participating in UTA\'s classes was lower in terms of: regular annual dental controls (161; 58.12%; vs. 265; 74.86%; p < 0.001), regular self-examination of breasts/testicles (148; 53.43% vs. 218; 61.58%; p = 0.04) and regular laboratory tests (232; 83.75% vs. 318; 89.83%; p = 0.02).
    UNASSIGNED: Health-promoting behaviors of seniors attending classes at the UTA\'s were more correct in terms of physical activity, adequate attendance with preventive test and worst in terms of alcohol consumption. Overall picture allows to conclude that participation in UTA\'s classes seems to have a positive impact on the examined health-promoting behaviors of the surveyed seniors.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    本研究旨在:1)探索城市社区中步行速度慢(SSWS)的老年人的行动体验;和2)调查他们的环境障碍和支持。
    对居住在重庆市市区的36个SSWS进行了访谈,中国。通过制图分析和专题分析揭示了影响其流动性的流动模式和建筑环境因素。
    SSWS主要将活动集中在其房屋半径400米的范围内。建筑环境主题包括地形,邻里服务,人行道,座位,交通安全,天气,绿化,和照明。重要的行动障碍包括长楼梯,陡坡,人行道上快速移动的物体,十字路口,和快速的交通。可用的扶手,附近的餐饮服务场所,充足的座位,绿化被确定为其流动性的支持因素。
    这项研究是第一个专门检查SSWS在建筑环境中的移动性的研究。我们建议在为通用设计框架建立基准时应考虑SSWS。这些改进不仅有助于慢步行者的流动性,而且对更广泛的人口产生积极影响。
    UNASSIGNED: This study aims to: 1) Explore the mobility experiences of seniors with slow walking speeds (SSWS) in urban neighborhoods; and 2) Investigate their environmental barriers and supports.
    UNASSIGNED: Go-along interviews were conducted with 36 SSWS residing in urban neighborhoods of Chongqing City, China. The mobility patterns and built environment factors influencing their mobility were revealed through cartographic analysis and thematic analysis.
    UNASSIGNED: SSWS primarily focused their activities within a 400-meter radius of their homes. Built environment themes included topography, neighborhood services, sidewalks, seating, traffic safety, weather, greenery, and lighting. Significant mobility barriers included long stairs, steep slopes, fast-moving objects on sidewalks, road crossings, and fast traffic. Available handrails, nearby food-service places, ample seating, and greenery were identified as supportive factors for their mobility.
    UNASSIGNED: This study stands out as the first to specifically examine the mobility of SSWS within the built environment. We suggest that SSWS should be taken into account when establishing a benchmark for general design frameworks. These improvements not only contribute to the mobility of slow walkers but also have positive impacts on the broader population.
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  • 文章类型: Journal Article
    大约三分之二因跌倒而被送往急诊科(ED)的患者在没有紧急治疗的情况下从急诊室出院。这项试点研究测试了实施由紧急医疗技术人员(EMT)执行的院前跌倒评估协议的可行性,以确定跌倒的患者是否需要ED评估或可以安全地转诊到社区资源。
    该方案由受过训练的EMT在2019年10月至2020年3月在舍布鲁克(QC)跌倒后对≥65岁的成年人进行管理。无论方案结果如何,所有患者均被转运至ED(推荐/不推荐转运)。目的是评估EMT是否可以完成协议,并就运输到ED做出适当的决定。次要目标旨在评估识别不需要运输的患者的准确性。并测量对可避免的救护车运输的影响。
    总共进行了125例EMT干预:17例患者属于不推荐运输组,占到医院与跌倒相关的EMT呼叫的14%,这是可以避免的。其中,110人被运送到ED。现场EMT干预的平均持续时间为31分钟。四十七名病人入院,主要是感染和骨折,包括不推荐运输组中的四个。
    这项研究表明,EMT可以实施跌倒评估方案,旨在识别需要进行ED评估的患者。结果允许在评估方案安全性的项目第二阶段之前修改方案。
    UNASSIGNED: Approximately two-thirds of patients transported to emergency departments (ED) for a fall are discharged from the ED without urgent treatment. This pilot study tests the feasibility of implementing a pre-hospital falls-assessment protocol performed by emergency medical technicians (EMTs) to determine whether a patient who fell needs an ED assessment or could be referred safely to a community resource.
    UNASSIGNED: The protocol was administered by trained EMTs to adults aged ≥ 65 after a fall between October 2019 and March 2020 in Sherbrooke (QC). All patients were transported to ED regardless of protocol outcome (transport recommended/not recommended). The objective was to assess if EMTs could complete the protocol and make the appropriate decision concerning the transport to ED. Secondary objectives aimed to assess the accuracy in identifying patients who do not require transport, and to measure the impact on avoidable ambulance transports.
    UNASSIGNED: A total of 125 EMTs interventions were carried out: 17 patients were in the transport not recommended group, representing 14% of transport to hospital for falls-related EMTs calls that could be possibly avoided. Of these, 110 were transported to ED. Mean duration of on-site EMTs interventions was of 31 minutes. Forty-seven patients were admitted, mostly for infections and fractures, including four in the transport not recommended group.
    UNASSIGNED: This study showed that EMTs can administer a falls-assessment protocol aimed at identifying patients that need an ED evaluation. Results permitted to amend the protocol before the second phase of the project evaluating the safety of the protocol.
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  • 文章类型: Journal Article
    在2023-2024年的秋季和冬季,美国可能会经历COVID-19,流感,和呼吸道合胞病毒(RSV),可能导致10万人死亡。老年人将受到不成比例的影响。新发布的针对60岁及以上人群的RSV疫苗可能会减少预计仅因RSV而死亡的6000至10000老年人的死亡人数。使用大规模的全国调查,我们向60岁以上的美国人询问了他们的RSV疫苗接种状况以及他们打算在今年秋季和冬季接种疫苗.我们发现9%的老年人已经接种了疫苗。剩下的未接种疫苗的人,42%的人表示他们打算接种疫苗。我们发现那些对这种疾病有更高担忧的人,自我评估的风险水平更高,相信疫苗是安全和重要的,对卫生机构的信任度更高,男性更有可能寻求疫苗接种。对疫苗犹豫不决的受访者列出了缺乏必要性,关注副作用和安全性,缺乏信息是主要原因。大量未接种疫苗的老年人可能会导致过多的住院和死亡以及增加的社会成本。应立即实施针对老年人关注的循证缓解措施。
    In the fall and winter of 2023-2024, the United States may experience a \"tripledemic\" of COVID-19, influenza, and respiratory syncytial virus (RSV) that may lead to 100 000 deaths. Seniors will be disproportionally affected. The newly released RSV vaccines for those age 60 years and over may reduce the number of deaths for the expected 6000 to 10 000 seniors expected to die from RSV alone. Using a large national survey, we queried Americans over age 60 about their RSV vaccination status and their intention to vaccinate this fall and winter. We found that 9% of seniors had already been vaccinated. Of the remaining unvaccinated, 42% indicated their intent to vaccinate. We found that those with higher levels of concerns for the disease, higher levels of self-assessed risk, believing that vaccines were safe and important, higher levels of trust in health institutions, and men were more likely to seek out vaccinations. Vaccine-hesitant respondents listed a lack of necessity, concerns about side effects and safety, and a lack of information as primary reasons. The large number of unvaccinated seniors will likely lead to an excessive number of hospitalizations and deaths as well as augmented social costs. Evidence-based mitigation measures tailored to seniors\' concerns should be implemented immediately.
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  • 文章类型: Journal Article
    背景:老年人(>65岁)对移动健康(mHealth)应用程序的采用正在迅速增加。然而,使用这些应用程序并没有完全有效地支持痴呆症患者及其护理者的日常生活。这主要归因于mHealth应用程序的异构质量,强调在开发与痴呆症相关的mHealth应用程序时需要提高应用程序质量。
    目的:这项研究的目的是(1)评估用于痴呆症管理的移动应用程序的质量和内容,以及(2)调查应用程序质量与下载量之间的关系。
    方法:我们回顾了台湾GooglePlay商店和AppleAppStore中与痴呆症相关的mHealth应用程序。根据随机抽样方法对确定的移动应用程序进行了分层,并由五名独立审稿人进行了评估,他们在mHealth和相关医疗保健部门领域接受了足够的培训和熟练程度。根据移动应用程序评级量表的用户版本对应用程序质量进行评分。然后在应用质量评分和应用下载次数之间进行相关性分析。
    结果:在评估的17个应用程序中,只有一个是专门设计来提供痴呆症相关的教育。整体应用质量的平均得分为3.35(SD0.56),量表的参与度(平均3.04,SD0.82)和信息(平均3.14,SD0.88)部分获得最低评级。我们的分析显示,排名前三和排名后三的应用程序之间存在明显差异,特别是在参与类别的娱乐和兴趣子部分,评分范围从1.4到5。前三名的应用程序在其界面中有一个共同的功能,其中包括记忆,注意,焦点,计算,和速度训练游戏,而获得较低评级的应用程序被发现在提供足够的信息方面存在缺陷。尽管下载次数(5000或更多)与应用程序质量之间存在相关性(t15=4.087,P<.001),这可能不是应用程序的感知影响的重要决定因素。
    结论:与痴呆症相关的mHealth应用程序的质量差异很大。特别是,我们的结果表明,前三名质量应用程序在参与度和信息方面表现良好,他们都收到了超过5000次下载。由于样本量小和忽略异常情况的可能性,这项研究的结果有限。公开的移动应用程序专家评级可以帮助痴呆症患者及其护理人员选择优质的mHealth应用程序。
    BACKGROUND: The adoption of mobile health (mHealth) apps among older adults (>65 years) is rapidly increasing. However, use of such apps has not been fully effective in supporting people with dementia and their caregivers in their daily lives. This is mainly attributed to the heterogeneous quality of mHealth apps, highlighting the need for improved app quality in the development of dementia-related mHealth apps.
    OBJECTIVE: The aims of this study were (1) to assess the quality and content of mobile apps for dementia management and (2) to investigate the relationship between app quality and download numbers.
    METHODS: We reviewed dementia-related mHealth apps available in the Google Play Store and Apple App Store in Taiwan. The identified mobile apps were stratified according to a random sampling approach and evaluated by five independent reviewers with sufficient training and proficiency in the field of mHealth and the related health care sector. App quality was scored according to the user version of the Mobile Application Rating Scale. A correlation analysis was then performed between the app quality score and number of app downloads.
    RESULTS: Among the 17 apps that were evaluated, only one was specifically designed to provide dementia-related education. The mean score for the overall app quality was 3.35 (SD 0.56), with the engagement (mean 3.04, SD 0.82) and information (mean 3.14, SD 0.88) sections of the scale receiving the lowest ratings. Our analyses showed clear differences between the top three- and bottom three-rated apps, particularly in the entertainment and interest subsections of the engagement category where the ratings ranged from 1.4 to 5. The top three apps had a common feature in their interface, which included memory, attention, focus, calculation, and speed-training games, whereas the apps that received lower ratings were found to be deficient in providing adequate information. Although there was a correlation between the number of downloads (5000 or more) and app quality (t15=4.087, P<.001), this may not be a significant determinant of the app\'s perceived impact.
    CONCLUSIONS: The quality of dementia-related mHealth apps is highly variable. In particular, our results show that the top three quality apps performed well in terms of engagement and information, and they all received more than 5000 downloads. The findings of this study are limited due to the small sample size and possibility of disregarding exceptional occurrences. Publicly available expert ratings of mobile apps could help people with dementia and their caregivers choose a quality mHealth app.
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  • 文章类型: Journal Article
    本研究针对“2022年台湾老年人健身俱乐部补贴计划”的老年人,并提供样本。
    医生将诊断并确认身体状况是否适合参与。然后,专业体育教练将设计并安排适合老年人身体素质的渐进式健身小组课程,每周进行四次,每2小时,为期三个月的集体课程培训。之后,四名小组课程教师通过视频分析了三个阶段的运动能力,分为21项评价指标。数据收集将于2023年1月至5月进行。此外,老年人综合护理(ICOPE)用于评估情况。
    结果显示,在第6周,所有指标均显着优于第1周。第12周的所有指标均明显优于第1周和第6周的指标(p<.001),所有指标的收益最大(科恩的d:2.79-5.11),各指标ICC得分的信度(0.73-0.94)。
    关于如何安全有效地增强老年人的身体活动的渐进和多方面的指导可能是最合适的方法。通过逐步增强能量,参与者的身体活动和认知功能可以得到改善,尤其是音乐的整体节奏,可以结合高和低冲击,动态和静态平衡控制,敏捷性,灵活性,和可扩展性,以实现健康促进的好处。
    UNASSIGNED: This study is aimed at the seniors of the \"2022 Taiwan Senior Citizens Fitness Club Subsidy Plan\" with a sample.
    UNASSIGNED: The doctor will diagnose and confirm whether the physical condition suits participation. Then, the professional sports instructor will design and arrange a progressive fitness enhancement group course suitable for the Senior person\'s physical fitness, conducted four times a week, every 2 h, for three months of group course training. Afterward, four group course instructors analyzed the motor ability of the three periods through a video, divided into 21 evaluation indicators. The data collection will be from January to May 2023. In addition, the Integrated Care for Old People (ICOPE) was used to assess the situation.
    UNASSIGNED: The results showed that all indexes were significantly better than those in week one at week 6. All indexes at week 12 were significantly better than those in week one and week 6 (p < .001), and the benefit of all indicators was the largest (Cohen\'s d: 2.79-5.11), the reliability of the scores of each index ICC (0.73-0.94).
    UNASSIGNED: Progressive and multifaceted guidance on how to safely and effectively enhance the physical activity of senior citizens may be the most suitable method. Through progressive energy enhancement, the participants\' physical activity and cognitive function can be improved, especially the overall rhythm of the music, which can be combined with high and low impact, dynamic and static balance control, agility, flexibility, and extensibility to achieve the benefits of health promotion.
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  • 文章类型: Journal Article
    背景:生理失调/同种异体负荷和老年综合征的虚弱随着年龄的增长而增加。作为一种神经生理反应系统,同种异体通过限制与应激源相关的损伤来支持生存。虚弱反映力量下降,耐力,和身体能力继发于肌肉和骨骼的损失随着年龄的增长。一个建议,基于对70岁以上人群的大型队列研究,脆弱有助于老年人的静力负荷。然而,基于社区的小型研究尚未证实这种特定的关联。
    方法:为了进一步探索同种异体载荷和脆弱之间可能的关联,我们招募了211名年龄在55-91岁的大波兰居民,他们住在一个小村庄(Nekla,N=104)和大波兰的城市中心和首都(波兹南,N=107)。对于每一个,我们记录了年龄,自我报告的性别,和居住地,并估计10个生物标志物的同种异体负荷评分(ALS)和8个生物标志物的脆弱指数。我们预计以下情况:男性和农村居民的ALS和身体虚弱较高;年龄较大时,ALS的身体虚弱而不是ALS较高;ALS与性别和居住地的显着关联,但不是年龄或虚弱。通过t检验和多变量回归评估观察到的关联的显著性。
    结果:ALS在男性和女性之间以及Nekla和Poznan居民之间没有显着差异。然而,女性的虚弱程度明显高于男性。Nekla男性表现出明显较高的ALS,但没有虚弱,而Nekla女性表现出非显著高于Poznan的ALS和较低的身体虚弱。在多变量分析中,无论是年龄,也不是性,居住也不与ALS相关。相反,年龄,性别,和居住,但不是ALS,与脆弱显著相关。在Nekla,年龄和性别,但在波兹南唯一的年龄,与ALS有关。在女性中,年龄和居住地,但是在男人中,与ALS无关。在任何情况下,ALS都不会与虚弱显着相关。
    结论:在此示例中,与居住相关的生活方式因素,年龄,和性别影响压力相关的生理,在女性中更少,而ALS和脆弱并不共存,表明它们的潜在启动子是不同的。生理失调与虚弱的类似复杂关联,年龄,性别,和住所可能存在于许多当地环境中。了解这种变化可能有助于支持老年人的健康和医疗保健服务。
    BACKGROUND: Physiological dysregulation/allostatic load and the geriatric syndrome frailty increase with age. As a neurophysiological response system, allostasis supports survival by limiting stressor-related damage. Frailty reflects decreased strength, endurance, and physical abilities secondary to losses of muscle and bone with age. One suggestion, based on large cohort studies of person\'s ages 70 + years, is that frailty contributes to allostatic load at older ages. However, small community-based research has not confirmed this specific association.
    METHODS: To further explore possible associations between allostatic load and frailty, we enrolled 211 residents of Greater Poland aged 55-91 years living in a small village (Nekla, N = 104) and an urban center and capital of Greater Poland (Poznan, N = 107). For each, we recorded age, self-reported sex, and residence and estimated a 10-biomarker allostatic load score (ALS) and an 8-biomarker frailty index. We anticipated the following: higher ALS and frailty among men and rural residents; for frailty but not ALS to be higher at older ages; significant associations of ALS with sex and place of residence, but not with age or frailty. The significance of observed associations was evaluated by t-tests and multivariate regression.
    RESULTS: ALS did not vary significantly between men and women nor between Nekla and Poznan residents overall. However, women showed significantly higher frailty than men. Nekla men showed significantly higher ALS but not frailty, while Nekla women showed nonsignificantly higher ALS and lower frailty than Poznan. In multivariate analyses, neither age, nor sex, nor residence was associated with ALS. Conversely, age, sex, and residence, but not ALS, are associated significantly with frailty. In Nekla, both age and sex, but in Poznan only age, are associated with ALS. Among women, both age and residence, but among men, neither associated with ALS. In no case did ALS associate significantly with frailty.
    CONCLUSIONS: In this sample, lifestyle factors associated with residence, age, and sex influence stress-related physiology, less so in women, while ALS and frailty do not covary, suggesting their underlying promoters are distinct. Similar complex associations of physiological dysregulation with frailty, age, sex, and residence likely exist within many local settings. Knowledge of this variation likely will aid in supporting health and healthcare services among seniors.
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