UNASSIGNED: In this paper, we studied how native (L1) speakers of Russian and speakers of Mandarin Chinese learning Russian as a foreign language (L2) process Russian sentences with different word orders. We compared SVO (canonical) and OVS (non-canonical) orders in isolation and in context. Experiments focusing on the L2 processing of different word orders are still not very numerous, and those using context are extremely rare.
UNASSIGNED: In Experiment 1, target sentences were presented in isolation. In Experiment 2, one-sentence contexts introduced one NP mentioned in the target sentence, either the first (so that given information preceded new information, which is characteristic for Russian and many other languages) or the second. As a result, two factors could be compared: the syntactic (word order) and the contextual (whether the context is appropriate from the information-structural perspective). We used different measures to capture online and offline effects: word-by-word reading times, question-answering accuracy and sentence rating on a 1 to 5 scale (for L1 participants).
UNASSIGNED: In both experiments, RTs and question-answering accuracy data showed that non-canonical orders were difficult for L2 participants, but not for L1 participants. However, L1 participants gave non-canonical orders lower ratings in isolation, presumably because in naturally occurring texts, they are used only in particular contexts. As for the context factor in Experiment 2, some effects were the same for L1 and L2 processing: all participants read given NPs faster than new ones and preferred sentences with a \'given - new\' word order. The latter may reflect the universal principles of narrative coherence. However, unlike native speakers, L2 readers are not sensitive to more subtle contextual requirements of different word orders.

Filler particles like uhm in English or ähm in German show subtle language-specific differences and their variation in form is related to socio-linguistic variables like gender. The use of fillers in a second language has been shown to differ from monolinguals\' filler particle use in both frequency and form in different language contexts. This study investigates the language-specific use of filler particles by bilingual heritage speakers in both their languages, looking at the dominant majority language in the society and their minority heritage language spoken at home. This is done based on heritage Russian and German data and majority German and English data from the RUEG corpus. Language-specific fillers were extracted from the corpus and analyzed for their occurrence and segmental form. The frequency analysis suggests an influence of bilingualism, age group, and formality of the situation on the filler frequency across all languages. The number of filler particles is higher in formal, older, and bilingual speech. The form analysis reveals an effect of language and gender on the type of filler particle. The vocalic-nasal filler particles (e.g., uhm) are more frequently found in German and English and in female speech of these languages. Heritage speakers of Russian in contact with German and English show higher use of vocalic-nasal forms also in their Russian while producing similar gender related patterns to monolingual speakers in both their languages. The higher frequency of filler particles in formal situations, older speakers and in bilingual speech, is discussed related to cognitive load which is assumed to be higher in these contexts while speech style which differs between situations and social groups is also considered as explanation. The higher use of vocalic-nasal filler particles in German and English suggests language specific filler particle preferences also related to the socio-linguistic variable gender in these languages. The results from heritage speakers suggest and influence on filler particle form in their heritage language, while also revealing socio-linguistic usage patterns related to gender which are produced by heritage speakers similarly to monolinguals in their respective language.

Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac disorder characterized by marked clinical and genetic heterogeneity. Ethnic groups underrepresented in studies may have distinctive characteristics. We sought to evaluate the clinical and genetic landscape of Russian HCM patients. A total of 193 patients (52% male; 95% Eastern Slavic origin; median age 56 years) were clinically evaluated, including genetic testing, and prospectively followed to document outcomes. As a result, 48% had obstructive HCM, 25% had HCM in family, 21% were asymptomatic, and 68% had comorbidities. During 2.8 years of follow-up, the all-cause mortality rate was 2.86%/year. A total of 5.7% received an implantable cardioverter-defibrillator (ICD), and 21% had septal reduction therapy. A sequencing analysis of 176 probands identified 64 causative variants in 66 patients (38%); recurrent variants were MYBPC3 p.Q1233* (8), MYBPC3 p.R346H (2), MYH7 p.A729P (2), TPM1 p.Q210R (3), and FLNC p.H1834Y (2); 10 were multiple variant carriers (5.7%); 5 had non-sarcomeric HCM, ALPK3, TRIM63, and FLNC. Thin filament variant carriers had a worse prognosis for heart failure (HR = 7.9, p = 0.007). In conclusion, in the Russian HCM population, the low use of ICD and relatively high mortality should be noted by clinicians; some distinct recurrent variants are suspected to have a founder effect; and family studies on some rare variants enriched worldwide knowledge in HCM.

Characterization of the novel HLA-C*07:1083 allele in a Russian bone marrow donor.

Language Mixing (LM) occurs among neurotypical bilinguals as well as among bilingual persons with aphasia (BiPWAs). The current study aimed to investigate whether LM in BiPWAs stems from a linguistic impairment, an impairment in cognitive control, or both.
Twenty Russian-Hebrew-speaking BiPWAs were split into two groups based on aphasia severity (Severe/Moderate vs. Mild). Frequencies and patterns of LM in narrative production by BiPWAs in L1-Russian and in L2-Hebrew were analyzed. To investigate the underlying mechanisms of LM, all participants completed linguistic background questionnaires, the Bilingual Aphasia Test (BAT) in both languages, and a battery of 10 cognitive tests.
The results indicated an effect of aphasia severity and an effect of language. Higher LM frequency was observed in BiPWAs with severe/moderate aphasia symptoms as compared to BiPWAs with mild symptoms. In both groups, higher LM frequency was observed in L2-Hebrew narratives, the weaker post-stroke language for most participants in the sample. The results also showed qualitative LM differences in L1-Russsian and L2-Hebrew contexts. In L1-Russian narratives, BiPWAs mainly switched to L2-Hebrew nouns, while in L2-Hebrew narratives, they mainly inserted L1-Russian discourse markers and function words.
Linguistic factors such as pre- and post-stroke self-rated language proficiency and level of language impairment due to aphasia were found to predict LM frequency in L1-Russian and in L2-Hebrew. Cognitive abilities did not predict LM frequency. Based on our findings, we suggest that LM behavior in BiPWAs might be primarily related to language skills in L1 and L2, rather than to cognitive control impairments.

The most validated health-related quality-of-life (HRQOL) questionnaire specific to the metastatic spine cancer population is the Spine Oncology Study Group Outcomes Questionnaire version 2 (SOSGOQ2.0). The purpose of this study was to translate and validate a Russian version of the SOSGOQ2.0.
The SOSGOQ2.0 was translated into Russian and cross-culturally adapted. In this study, 64 eligible patients completed the SOSGOQ2.0_RUS along with the EQ-5D 5 Level, SF-36 quality-of-life questionnaires, and visual analog scale for pain assessment scale (VAS). Internal consistency was measured using Cronbach\'s alpha, in which a score of 0.65 or higher is acceptable. Test-retest reliability was evaluated by examining the intraclass correlation coefficient (ICC).
Included in this study were 64 Russian-speaking patients (median age 59 years) with metastatic spine disease. The most common primary tumors were breast, kidney, and prostate cancers. The overall Cronbach\'s alpha was 0.87, indicating high internal consistency. The overall ICC for the SOSGOQ2.0_RUS was 0.88 (95% CI 0.81-0.93), indicating high reliability and consistency of the measure. The physical function, pain, and mental health domains of the SF-36 moderately correlated with the same domains of the SOSGOQ2.0_RUS, with correlation coefficients ranging from 0.65 to 0.71.
The SOSGOQ2.0_RUS is a reliable and valid questionnaire for assessing the HRQOL in patients with metastatic spinal tumors. The questionnaire showed high internal consistency, test-retest reliability, and good construct validity when compared with other established questionnaires.

The HLA-B*35:02:21 allele differs from HLA-B*35:02:01:01 in codon 183 in exon 4.

This article focuses on the choice of nominal forms in a language with articles (Catalan) in comparison to a language without articles (Russian). An experimental study (consisting of various naturalness judgment tasks) was run with speakers of these two languages which allowed to show that in bridging contexts native speakers\' preferences vary when reference is made to one single individual or to two disjoint referents. In the former case, Catalan speakers chose (in)definite NPs depending on their accessibility to contextual information that guarantees a unique interpretation (or the lack of it) for the entity referred to. Russian speakers chose bare nominals as a default form. When reference is made to two disjoint referents (as encoded by the presence of an additional altre/drugoj \"other\" NP), speakers prefer an optimal combination of two indefinite NPs (i.e., un NP followed by un altre NP in Catalan; odin \"some/a\" NP followed by drugoj NP in Russian). This study shows how speakers of the two languages manage to combine grammatical knowledge (related to the meaning of the definite and the indefinite articles and altre in Catalan; and the meaning of bare nominals, odin and drugoj in Russian) with world knowledge activation and accessibility to discourse information.

Three novel alleles were characterized by next-generation sequencing in Russian individuals.

HLA genes play a major role for successful hematopoietic stem cell transplantation (HSCT). While the success of HSCT depends on a HLA compatibility between donor and patient, finding a suitable donor remains challenging because of the high polymorphic nature of HLA genes. In this study, HLA-A, -B, -C, -DRB1 and -DQB1 alleles were genotyped at the 3-fields resolution level using MiSeq Illumina of 3341 Russian volunteers from the Kirov bone marrow Registry. Full gene of HLA-A, -B and -C, exons 2-4 of HLA-DRB1 and exons 1-5 of HLA-DQB1 were amplified by multiplex long-range polymerase chain reaction (PCR) and each allele was determined by matching the targeted regions and the reference sequence consisting of the IPD-IMGT/HLA Database. A total of 79 alleles of HLA-A, 115 alleles of HLA-B, 67 alleles of HLA-C, 71 alleles of HLA-DRB1 and 34 alleles of HLA-DQB1 were identified. According to common, intermediate and well-documented catalogs, 38 alleles in HLA-A, 69 in HLA-B, 39 in HLA-C, 48 in HLA-DRB1 and 21 in HLA-DQB1 locus were common alleles, and 5, 7, 7, 7, 2 kinds, accordingly, to written above were well-documented alleles. A total of 12 novel alleles including 3 alleles in HLA-A, 3 alleles in HLA-B, 1 allele in HLA-C, 2 alleles in HLA-DRB1 and 3 alleles in HLA-DQB1 loci were found. Six haplotypes with a frequency of more than 1.0% accounted for 13.19% of the total haplotype frequencies. This information on rare and novel alleles found by HLA typing with NGS may be helpful for unrelated HSCT among Russians.