背景:生活在欧洲国家的非洲和中东血统的人患有2型糖尿病,伴随着女性肥胖的高患病率,但并非总是在男性中。这项研究的目的是检查芬兰移民人群的人体测量法与糖化血红蛋白和空腹血糖测量的血糖水平之间的关联是否存在差异。
方法:使用了移民健康与福祉研究健康检查中30-64岁参与者的基于人群的横断面数据,选择没有糖尿病的人(俄罗斯血统n=293,索马里血统n=184,库尔德血统n=275)。参照组是2011年健康调查中的非糖尿病参与者(n=653),代表芬兰总人口。人体测量包括体重指数(BMI),腰围(WC),腰围身高比(WHtR)和腰臀比(WHR,仅适用于Maamu研究参与者)。
结果:根据使用的是连续的还是分类的人体测量,年龄,性别和人体测量学解释了俄罗斯血统人群中HbA1c变化的13-18%,5-10%来自索马里的人,在库尔德人中占1-3%,在普通人群中占11-13%。还取决于是否使用连续或分类的人体测量,年龄,性别和人体测量学解释了13-19%的空腹血糖变化俄罗斯人,15-20%来自索马里的人,库尔德人中有13-17%,一般人口中有16-17%。除了BMI,与一般芬兰人群相比,库尔德人群的连续人体测量值与HbA1c之间的关联强度显著较低(WCp=0.044,WHtRp=0.040).
结论:在库尔德人中观察到人体测量与HbA1c之间的关联程度较低。这项研究的结果表明,在不同来源的非糖尿病人群中,使用HbA1c作为葡萄糖损害的筛查工具时,需要谨慎。
BACKGROUND: Persons of African and Middle-Eastern origin living in European countries have a high prevalence of type 2 diabetes, accompanied by high prevalence of obesity among women but not always among men. The aim of this
study was to examine whether there are differences in the association between anthropometric measures and glucose levels measured with glycated haemoglobin and fasting blood glucose among persons of migrant origin in Finland.
METHODS: Cross-sectional population-based data of the 30-64 year-old participants in the health examination of the Migrant Health and Wellbeing Study was used, selecting persons without diabetes (
Russian origin n = 293, Somali origin n = 184, Kurdish origin n = 275). The reference group were non-diabetic participants in the Health 2011 Survey (n = 653), representative of the general Finnish population. Anthropometric measures included body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) and waist-to-hip ratio (WHR, available for Maamu Study participants only).
RESULTS: Depending on whether continuous or categorical anthropometric measures were used, age, sex and anthropometrics explained 13-18% of variation in HbA1c among persons of
Russian origin, 5-10% among persons of Somali origin, 1-3% among persons of Kurdish origin and 11-13% among the general population. Also depending on whether continuous or categorical anthropometric measures were used, age, sex and anthropometrics explained 13-19% of variation in fasting blood glucose among persons of
Russian origin, 15-20% among persons of Somali origin, 13-17% among persons of Kurdish origin and 16-17% among the general population. With exception for BMI, strength of the association between continuous anthropometric measures and HbA1c was significantly lower among persons of Kurdish origin compared with the general Finnish population (p = 0.044 for WC and p = 0.040 for WHtR).
CONCLUSIONS: A low degree of association between anthropometric measures and HbA1c was observed among persons of Kurdish origin. Findings of this
study suggest caution is warranted when using HbA1c as a screening tool for glucose impairment among persons without diabetes in populations of diverse origin.