背景:先前的研究表明,多囊卵巢综合征(PCOS)的患病率可能因种族/民族而异,尽管很少有研究评估生活在相似地理和社会经济条件下的不同种族的女性。
目的:确定未选择的绝经前妇女多种族人群中PCOS的患病率。
方法:多中心前瞻性横断面研究。
方法:伊尔库茨克地区和布里亚特共和国的主要地区雇主,俄罗斯。
方法:在2016-19年期间,1398名绝经前妇女接受了病史和体检,盆腔超声,在强制性的年度就业相关健康评估中进行测试。
方法:PCOS患病率,总体上和按种族划分,在大量的医学上没有偏见的人口中,包括白种人(白人),蒙古语或亚洲(布里亚特),和混血儿,几个世纪以来生活在相似的地理和社会经济条件下。
结果:在对PCOS进行完整评估的165/1134名(14.5%)女性中诊断为PCOS。根据在接受完整评估的女性队列中观察到的PCOS临床表现的概率,我们还估计了264名评估不完整的女性的体重调整后的PCOS患病率:46.2或17.5%。因此,PCOS在人群中的总患病率为15.1%,与亚洲人相比,高加索人和混合种族妇女更高(16.0%和21.8%vs.10.8%,pz<0.05)。
结论:我们观察到,在绝经前妇女的医学无偏人群中,PCOS的患病率为15.1%。在这个西伯利亚绝经前白种人的女性人群中,生活在相似地理和社会经济条件下的亚洲和混合种族,高加索或混合人群的患病率高于亚洲女性.这些数据强调需要仔细评估PCOS的频率和临床表现的种族依赖性差异。
BACKGROUND: Previous studies have shown that the prevalence of polycystic ovary syndrome (PCOS) may vary according to race/ethnicity, although few studies have assessed women of different ethnicities who live in similar geographic and socio-economic conditions.
OBJECTIVE: To determine the prevalence of PCOS in an unselected multiethnic population of premenopausal women.
METHODS: A multicenter prospective cross-sectional study.
METHODS: The main regional employers of Irkutsk Region and the Buryat Republic, Russia.
METHODS: During 2016-19, 1398 premenopausal women underwent a history and physical exam, pelvic ultrasound, and testing during a mandatory annual employment-related health assessment.
METHODS: PCOS prevalence, overall and by ethnicity in a large medically unbiased population, including Caucasian (White), Mongolic or Asian (Buryat), and mixed ethnicity individuals, living in similar geographic and socio-economic conditions for centuries.
RESULTS: PCOS was diagnosed in 165/1134 (14.5%) women who had a complete evaluation for PCOS. Based on the probabilities for PCOS by clinical presentation observed in the cohort of women who had a complete evaluation we also estimated the weight-adjusted prevalence of PCOS in 264 women with an incomplete evaluation: 46.2 or 17.5%. Consequently, the total prevalence of PCOS in the population was 15.1%, higher among Caucasians and women of Mixed ethnicity compared to Asians (16.0% and 21.8% vs. 10.8%, pz <0.05).
CONCLUSIONS: We observed a 15.1% prevalence of PCOS in our medically unbiased population of premenopausal women. In this population of Siberian premenopausal women of Caucasian, Asian and Mixed ethnicity living in similar geographic and socio-economic conditions, the prevalence was higher in Caucasian or Mixed than Asian women. These data highlight the need to assess carefully ethnic-dependent differences in the frequency and clinical manifestation of PCOS.