本研究旨在探讨阴道微生物群系失调与多囊卵巢综合征(PCOS)之间的潜在关系。根据预先确定的排除和纳入标准,使用四个数据库来识别主要文献。搜索到的电子数据库包括MEDLINE,Embase,Cochrane对照试验登记册(中央),护理和相关健康文献累积指数(CINAHL),和WebofScience。在最初的双盲筛选和删除重复项之后,还有81条。根据预选的纳入和排除标准纳入文章,研究类型,和发布日期。具体来说,纳入了主要文献,这些文献集中于被诊断为PCOS的受试者,并讨论了PCOS与阴道微生物组的关系.文献综述,动物科目的研究,未讨论PCOS和阴道微生物组的研究被排除.这篇综述中包含的五篇文章的最新数据表明,PCOS与阴道微生物群系失调之间存在关系。具体来说,阴道菌群的生态失调可能是由于阴道pH值改变继发于阴道乳酸杆菌减少和包括链球菌在内的致病物种升高,放线菌,普雷沃氏菌,加德纳菌,和支原体物种。这种阴道微生物群系失调的表现通常是细菌性和真菌性阴道炎。因此,需要更多的研究来探索用益生菌治疗PCOS的可能性,这些益生菌旨在重建健康的乳杆菌优势的阴道微生物组.此外,对PCOS患者阴道菌群微生物组成的进一步研究可以确定诊断PCOS的微生物生物标志物.
The aim of this scoping
review was to explore the potential relationship between vaginal microbiome dysbiosis and polycystic ovarian syndrome (PCOS). Four databases were utilized to identify primary literature based on a pre-determined exclusion and inclusion criteria. The electronic databases searched include MEDLINE, Embase, Cochrane Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. After an initial double-blind screening and removal of duplicates, 81 articles remained. Articles were included based on preselected inclusion and exclusion criteria, type of study, and date of publishing. Specifically, primary literature that focused on subjects that were diagnosed with PCOS and that discussed PCOS in relation to the vaginal microbiome was included. Literature reviews, studies with animal subjects, and studies that did not discuss PCOS and the vaginal microbiome were excluded. Current data from the five articles included in this
review suggests that there is a relationship between PCOS and vaginal microbiome dysbiosis. Specifically, dysbiosis of the vaginal flora may be due to vaginal pH alterations secondary to decreased vaginal Lactobacillus species and elevated pathogenic species including Streptococcus, Actinomyces, Prevotella, Gardnerella, and Mycoplasma species. The manifestation of this vaginal microbiome dysbiosis is often bacterial and fungal vaginitis. Therefore, more studies are needed to explore the possibility of treating PCOS with probiotics designed to reestablish a healthy Lactobacillus-dominant vaginal microbiome. In addition, further studies on the microbial composition of the vaginal microbiota in PCOS patients could identify microbial biomarkers for diagnosing PCOS.