{Reference Type}: Journal Article
{Title}: Association of classic and 11-oxygenated androgens with polycystic ovaries and menstrual cycle prolongation in infertile women with PCOS.
{Author}: Ma C;Xu H;Zhang X;Feng G;Shi L;Su Y;Yang L;Zhao R;Qiao J;
{Journal}: Clin Chim Acta
{Volume}: 547
{Issue}: 0
{Year}: 2023 Jul 1
{Factor}: 6.314
{DOI}: 10.1016/j.cca.2023.117440
{Abstract}: <B>OBJECTIVE: </B>The etiology of polycystic ovary syndrome (PCOS) is unclear. This study aimed to evaluate the role of classic and 11-oxygenated (11oxyC19) androgens in two typical signs of PCOS, polycystic ovary morphology (PCOM) and menstrual cycle prolongation.<BR><B>METHODS: </B>A total of 462 infertile women with diagnosed PCOS and/or commonly accompanied metabolic disorders were recruited. Classic and 11oxyC19 androgens were determined with a sensitive high-performance liquid chromatography-differential mobility spectrometry tandem mass spectrometry apparatus. Least absolute shrinkage and selection operator logistic regression with fivefold cross-validation was applied to construct prediction models.<BR><B>RESULTS: </B>For PCOM, the most significant contributing androgen was testosterone (T), with the weight of 51.6%. The AUC of the prediction model was 0.824 in validation set. For menstrual cycle prolongation, androstenedione (A4) was the most significant contributing androgen with weights of 77.5%. The AUC the prediction model was less than 0.75. When including other variables, the most significant variable turned to be AMH both in PCOM and in menstrual cycle prolongation.<BR><B>CONCLUSIONS: </B>Androgens had more contribution in PCOM than in menstrual cycle prolongation. The classic androgen T or A4 contributed more than 11oxyC19 androgens. However, their contributions were diminished when other factors were considered, especially AMH.