目的:MASCC/ISOO临床实践声明(CPS)旨在为临床医生提供简洁的工具,它集中了癌症患者口腔并发症管理所需的实用信息。该CPS的重点是慢性移植物抗宿主病(cGVHD)的口腔表现的管理。
方法:本CPS是在对文献进行批判性评估的基础上开发的,随后是一组领先专家的结构化讨论。MASCC/ISOO口腔护理研究小组的成员。该信息以简洁的项目符号和表格的形式呈现,以生成有关最佳护理标准的简短手册。
结果:口服cGVHD的治疗目标是缓解疼痛和口干症,改善口腔功能,防止继发感染,防止牙列恶化,并尽早发现恶性转化。口腔粘膜病变的预防和治疗措施,唾液腺功能减退,详细介绍了口腔和口周组织的硬皮病变化,以及这些干预措施可能的并发症和副作用。
结论:异基因造血细胞移植后的患者,在口腔和口周组织中表现出cGVHD,应定期监测并根据需要由口腔护理从业者进行治疗。这种CPS为临床医生提供了实用的检查工具,预防,并治疗可能影响这些患者口腔的各种后遗症。
OBJECTIVE: A MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise tool for clinicians, which concentrates practical information needed for the management of oral complications of cancer patients. This CPS is focused on the management of oral manifestations of chronic graft-versus-host-disease (cGVHD).
METHODS: This CPS was developed based on critical evaluation of the literature followed by a structured discussion of a group of leading experts, members of the Oral Care Study Group of MASCC/ISOO. The information is presented in the form of succinct bullets and table to generate a short manual about the best standard of care.
RESULTS: The treatment goals in oral cGVHD are to relieve pain and xerostomia, improve oral function, prevent secondary infection, prevent deterioration of the dentition, and detect malignant transformation as early as possible. The prevention and treatment measures for oral mucosal lesions, hypofunction of the salivary glands, and sclerodermatous changes in the oral and perioral tissues are detailed, as well as the possible complications and side effects of these interventions.
CONCLUSIONS: Patients post allogeneic hematopoietic cell transplantations, with cGVHD manifest in the oral and perioral tissues, should be regularly monitored and treated as needed by an oral care practitioner. This CPS provides the clinician with practical tools for examining, preventing, and treating the various sequalae that may affect the oral cavity in these patients.