关键词： AGE, Advanced glycation end products ALT, Alanine aminotransferase AMPK, AMP-activated protein Kinase APPL1 and 2, Adaptor protein 1 and 2 ATP, Adenosine tri-phosphatase BMI, Basal Metabolic Index CD, Cluster of differentiation COL13A1, Collagen, type XIII, alpha 1 DAMP, Damage assocauted molecular pattern molecules EFCAB4B, EF-hand calcium binding domain 4B FA, Fatty acid FDFT1, Farnesyl-diphosphate farnesyltransferase 1 FFA, Free fatty acid GCKR, Glucokinase regulatory protein GLUT 5, Glucose transporter type 5 GWAS, Genome wide association studies HDL, High density lipoprotein HMGB1, High-mobility group protein B1 HOMA-IR, Homoestatic model assessment-insulin resistance HSC, Hepatic Stellate Cells Hh, Hedgehog IL6, Interleukin 6 IR, Insulin Resistance KC, Kupffer Cells LPS, Lipopolysacharrides LYPLAL1, Lypophospholipase like 1 MCP, Monocyte chemotactic protein NAD, Nicotinamide adenine dinucleotide NAFL, Nonalcoholic fatty liver NAFLD, Nonalcoholic fatty liver disease NASH, Nonalcoholic steatohepatitis NCAN, Neurocan gene NF-KB, Nuclear Factor Kappa B NK, Natural Killer NKL, Natural Killer T cells NLR, NOD like receptor NNMT, Nicotinamide N-methyltransferase gene OXLAM, Oxidized linolenic acid metabolite PAMP, Pathogen-associated Molecular pattern PARVB, Beta Parvin Gene PDGF, Platelet-derived growth factor PNPLA3 PNPLA3, Patatin-like phospholipase domain-containing protein 3 PPAR-α, Peroxisome proliferator activated receptor alpha PPP1R3B, Protein phosphatase 1 R3B PUFA, Poly unsaturated fatty acid PZP, Pregnancy-zone protein ROS, Reactive oxygen species SAMM, Sorting and assembly machinery component SCAP, SREBP cleavage-activating protein SFA, Saturated fatty acid SNP, Single nucleotide polymorphism SOCS3, Suppressor of cytokine signaling 3 SOD2, Superoxide dismutase 2 gene SREBP-1C, Sterol regulatory Element—Binding Protein 1-C gene TLR, Toll like receptor TNF α, Tumor necrosis factor Alpha UCP3, Uncoupling protein 3 gene adiponectin cytokines gut microbiota lipotoxicity

来  源：   DOI：10.1016/j.jceh.2015.02.002   PDF(Sci-hub)

Abstract：
Nonalcoholic fatty liver (NAFL) is an emerging global epidemic which progresses to nonalcoholic steatohepatitis (NASH) and cirrhosis in a subset of subjects. Various reviews have focused on the etiology, epidemiology, pathogenesis and treatment of NAFLD. This review highlights specifically the triggers implicated in disease progression from NAFL to NASH. The integrating role of genes, dietary factors, innate immunity, cytokines and gut microbiome have been discussed.
摘要：
非酒精性脂肪肝（NAFL）是一种新兴的全球流行病，在一部分受试者中发展为非酒精性脂肪性肝炎（NASH）和肝硬化。各种评论都集中在病因上，流行病学,NAFLD的发病机制和治疗。这篇综述特别突出了与从NAFL到NASH的疾病进展有关的触发因素。基因的整合作用，饮食因素，先天免疫,已经讨论了细胞因子和肠道微生物组。
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