■2型糖尿病(T2D)是一种常见的慢性代谢性疾病,而且它的患病率在全球范围内都在增加。运动对于T2D管理至关重要,然而,其机制的许多方面仍不清楚。本研究利用CiteSpace揭示了T2D运动干预的研究热点和前沿问题。
■使用WebofScienceCoreCollection(WoSCC)进行了从2013年1月1日至2022年12月31日的文献综述,关键字包括“锻炼”,2型糖尿病,“和”机制。“我们分析了CiteSpace生成的网络图,描绘了国家之间的关系,作者,和关键词。
■这项研究包括来自555种期刊的1,210篇英语论文,隶属于80个国家/地区的348个机构。值得注意的是,美国,中国,英国占所有出版物的近一半。哥本哈根大学在出版量方面领先,其次是哈佛医学院和科罗拉多大学。主要作者包括Kirwan,约翰·P(凯斯西储大学),马林,史蒂文·K(罗格斯大学),还有Pedersen,BenteKlarlund(哥本哈根大学)。基于关键词的共现分析,很明显,诸如“疾病”之类的术语,“胰高血糖素样肽1”和“心血管危险因素”表现出很高的中介中心性。
■分析重点介绍了正在进行的分子机制研究,如β细胞功能增强,exerkines,和表观遗传机制。新兴领域包括运动反应异质性,昼夜节律调节,转录因子,神经营养因子,和线粒体功能。未来的研究应该优先理解不同运动机制之间的相互作用,并优化T2D的运动处方。运动处方对于有效的干预措施至关重要。国家和机构之间的合作对于了解不同遗传背景和环境因素的影响至关重要。目前,有氧和阻力训练的结合被认为是最佳的锻炼形式。然而,考虑到时间效率,高强度间歇训练(HIIT)由于能够在较短的时间内达到类似的运动效果而获得了广泛的关注和研究。此外,昼夜节律调节可能会影响糖尿病个体在一天中不同时间的运动结果,特别是关于特定类型,剂量,和用于T2D精确干预的强度。
UNASSIGNED: Type 2 diabetes (T2D) is a common chronic metabolic disease, and its prevalence is increasing globally.
Exercise is crucial for T2D management, yet many aspects of its mechanisms remain unclear. This study employs CiteSpace to reveal research hotspots and frontier issues in
exercise intervention for T2D.
UNASSIGNED: A literature review spanning from January 1, 2013 to December 31, 2022, was conducted using the Web of Science Core Collection (WoSCC), with keywords including \"exercise,\" \"type 2 diabetes,\" and \"mechanisms.\" We analyzed network diagrams generated by CiteSpace, which depicted relationships among countries, authors, and keywords.
UNASSIGNED: This study includes 1,210 English papers from 555 journals, affiliated with 348 institutions across 80 countries/regions. Notably, the United States, China, and the United Kingdom account for nearly half of all publications. The University of Copenhagen leads in publication volume, followed by Harvard Medical School and the University of Colorado. Key authors include Kirwan, John P (Case Western Reserve University), Malin, Steven K (Rutgers University), and Pedersen, Bente Klarlund (University of Copenhagen). Based on co-occurrence analysis of keywords, it is evident that terms such as \"disease,\" \"glucagon-like peptide 1,\" and \"cardiovascular risk factor\" exhibit high intermediary centrality.
UNASSIGNED: The analysis highlights ongoing investigations into molecular mechanisms, such as β-cell function enhancement, exerkines, and epigenetic mechanisms. Emerging areas include exercise response heterogeneity, circadian rhythm regulation, transcription factors, neurotrophic factors, and mitochondrial function. Future studies should prioritize understanding interactions between different
exercise mechanisms and optimizing
exercise prescriptions for T2D.
Exercise prescriptions are crucial for effective interventions. Collaboration between countries and institutions is essential to understand the influences of different genetic backgrounds and environmental factors. Currently, a combination of aerobic and resistance training is considered the optimal form of exercise. However, considering time efficiency, high-intensity interval training (HIIT) has gained widespread attention and research due to its ability to achieve similar exercise effects in a shorter duration. Additionally, circadian rhythm regulation may affect the exercise outcomes of diabetic individuals at different times of the day, particularly concerning the specific types, doses, and intensities used for precision intervention in T2D.