目的:莫拉氏菌是一种非常罕见的病原体,可导致微生物性角膜炎(MK)。本研究旨在评估临床特征,诱发因素,三级眼科医院患者莫拉氏菌角膜炎的结局。
方法:这项回顾性研究于2015年至2022年进行,对在转诊眼科医院经阳性培养证实诊断为莫拉氏菌角膜炎的患者进行了研究。人口统计,诱发因素,最佳矫正视力(BCVA),并评估预后。
结果:共106例被诊断为莫拉氏菌角膜炎,进行了分析。平均年龄为54.42±19.43岁。患者的平均基线BCVA为2.28±0.6LogMAR,而在6个月的随访中,该量达到1.49±0.81(P值=0.02)。需要手术干预的患者在六个月随访中的平均BCVA显着低于仅接受药物治疗的患者(2.15±0.65vs.1.29±0.75LogMAR,P值=0.02)。糖尿病患者和非糖尿病患者的角膜穿孔患病率没有明显差异(P值=0.515)。三个诱发因素包括角膜穿孔(比值比=19.27,P值=0.001),高血压(HTN)(比值比=3.62,P值=0.03),年龄较大(比值比=1.03,P值=0.008)与更多的手术干预需求显著相关.
结论:在这个队列中,发现莫拉氏菌角膜炎需要手术干预的不良预后与角膜穿孔有关,HTN,和老年。
OBJECTIVE: The Moraxella species is a very uncommon pathogen that leads to microbial keratitis (MK). This study aimed to evaluate the clinical features, predisposing factors, and outcomes of Moraxella keratitis in patients of a tertiary eye hospital.
METHODS: This retrospective study was conducted from 2015 to 2022, on patients who were admitted with the diagnosis of Moraxella keratitis confirmed by positive culture in a referral eye hospital. Demographics, predisposing factors, best-corrected visual acuity (BCVA), and prognosis were assessed.
RESULTS: A total of 106 individuals diagnosed with Moraxella keratitis, were analyzed. The mean age was 54.42 ± 19.43 years. The mean baseline BCVA of the patients was 2.28 ± 0.6 LogMAR, while this amount reached 1.49 ± 0.81 in the 6-month follow-up (P-value = 0.02). The mean BCVA in the six-month follow-up of the patients who needed surgical interventions was significantly lower than the patients who received only medical treatment (2.15 ± 0.65 vs. 1.29 ± 0.75 LogMAR, P-value = 0.02). Patients with diabetes and those without diabetes did not substantially vary in the prevalence of corneal perforation (P-value = 0.515). Three predisposing factors including corneal perforation (odds ratio = 19.27, P-value = 0.001), hypertension (HTN) (odds ratio = 3.62, P-value = 0.03), and older age (odds ratio = 1.03, P-value = 0.008) were significantly associated with more need for surgical interventions.
CONCLUSIONS: In this cohort, poor prognosis necessitating surgical interventions in Moraxella keratitis was found to be associated with corneal perforation, HTN, and older age.