PDF(Pubmed)
Abstract：
Corneal melt and perforation can arise from various etiologies, including the use of toxic topical drops, particularly topical non-steroidal anti-inflammatory drugs (NSAIDs). The literature has frequently documented the association between the use of topical NSAIDs and the subsequent development of corneal ulcers. More recently, reports have emerged linking the use of oral NSAIDs and colchicine to impaired corneal wound healing and corneal perforation. This case report presents an instance of corneal melting and subsequent perforation in a medically unburdened patient who had been self-administering oral NSAIDs for one year. The evidence presented in this report suggests a plausible association between the prolonged administration of oral NSAIDs and corneal melt. Consequently, healthcare practitioners should be mindful of this potential risk when considering the prolonged use of oral NSAIDs.
摘要：
角膜融化和穿孔可由各种病因引起，包括使用有毒的局部滴剂，特别是局部非甾体抗炎药（NSAIDs）。文献经常记录局部使用NSAIDs与随后的角膜溃疡发展之间的关联。最近,已有报道将口服NSAIDs和秋水仙碱的使用与角膜伤口愈合受损和角膜穿孔联系起来.此病例报告提供了一个无医学负担的患者的角膜融化和随后的穿孔的实例，该患者已自行口服NSAIDs一年。本报告中提供的证据表明，长期口服NSAIDs与角膜融化之间存在合理的联系。因此,在考虑长期口服NSAIDs时,医护人员应注意这一潜在风险.
