背景:寻常痤疮是一种非常常见的炎症性皮肤病,显著影响受影响个体的生活质量。以前的研究表明,寻常痤疮患者的锌含量通常较低,硒,和维生素D。然而,这三种营养素很少在一项研究中被共同检查。这项研究的目的是比较血清锌水平,硒,与对照组相比,寻常痤疮患者的维生素D。
方法:这项病例对照研究包括100名在皮肤科诊所就诊的寻常痤疮成年患者,在2020年。在同一诊所就诊的100名没有寻常痤疮的患者作为对照组进行了评估。参与者的社会人口统计学特征,包括年龄,性别,职业,酒精消费,和吸烟记录。此外,人体测量指数,比如体重和身高,测量并相应计算体重指数(BMI)。使用Tutakne和Chari的分级系统确定痤疮严重程度。血清锌,硒,并对所有参与者的外周血样本中的维生素D水平进行评估。
结果:痤疮患者和对照组的年龄相当,性别,体重,高度,BMI,职业,酒精消费,和吸烟(p>0.05)。血清锌,硒,痤疮患者的维生素D水平均明显低于对照组(p<0.001)。此外,锌和维生素D水平异常的频率在痤疮患者中显著较高(分别为p=0.002和p=0.001),但是两组之间在血清硒水平异常方面没有显着差异(p=0.228)。此外,血清锌,硒,与其他疾病严重程度等级相比,4级痤疮患者的维生素D水平较低(p<0.001)。
结论:寻常痤疮患者的血清锌水平较低,硒,和维生素D与对照组相比。此外,疾病的严重程度与这些营养素的低水平之间存在相关性。
BACKGROUND: Acne vulgaris is a very common inflammatory skin disease that significantly impacts the quality of life of affected individuals. Previous studies have indicated that individuals with acne vulgaris often have low levels of zinc, selenium, and vitamin D. However, these three nutrients have rarely been collectively examined in a single study. The objective of this study was to compare serum levels of zinc, selenium, and vitamin D in patients with acne vulgaris in comparison to a control group.
METHODS: This case-control study included 100 adult patients with acne vulgaris attending a dermatology clinic, in 2020. A group of 100 patients without acne vulgaris attending the same clinics were evaluated as controls. Participants\' sociodemographic characteristics, including age, sex, occupation, alcohol consumption, and tobacco smoking were recorded. In addition, anthropometric indices, such as weight and height, were measured and the body mass index (BMI) was calculated accordingly. Acne severity was determined using Tutakne and Chari\'s grading system. Serum zinc, selenium, and vitamin D levels were evaluated in peripheral blood samples of all the participants.
RESULTS: Acne patients and controls were comparable regarding age, sex, weight, height, BMI, occupation, alcohol consumption, and tobacco smoking (p > 0.05). Serum zinc, selenium, and vitamin D levels were all significantly lower in acne patients than in controls (p < 0.001). Furthermore, the frequency of abnormal zinc and vitamin D levels was significantly higher in acne patients (p = 0.002 and p = 0.001, respectively), but there was no significant difference between the two groups regarding abnormal serum selenium levels (p = 0.228). Also, serum zinc, selenium, and vitamin D levels lower levels in patients with grade 4 acne compared to other disease severity grades (p < 0.001).
CONCLUSIONS: Patients with acne vulgaris have lower levels of serum zinc, selenium, and vitamin D compared to the control group. Additionally, there is a correlation between the severity of the disease and lower levels of these nutrients.