PDF(Pubmed)
Abstract：
Pre-eclampsia and eclampsia are the second leading causes of maternal mortality and morbidity. It also results in high perinatal mortality and morbidity. Since eclampsia is preceded by preeclampsia and shows the progression of the disease, they share the same pathogenesis and determining factors. The purpose of this study was to determine determinants of preeclampsia, since it is essential for its prevention and/or its associated consequences. An unmatched case-control study was conducted from September 1-30, 2023 among women who gave birth from June 1, 2020, to August 31, 2023, at Hiwot Fana Comprehensive Specialized University Hospital. Women who had preeclampsia were considered cases, while those without were controls. The sample size was calculated using EPI Info version 7 for a case-control study using the following assumptions: 95% confidence interval, power of 80%, case-to-control ratio of 1:2, and 5% non-response rate were 305. Data was collected using Google Form, and analyzed using SPSS version 26. Variables that had a p-value of < 0.05 on multivariable logistic regression were considered statistically significant, and their association was explained using an odds ratio at a 95% confidence interval. A total of 300 women (100 cases and 200 controls) with a mean age of 24.4 years were included in the study. Rural residence (AOR 2.04, 95% CI 1.10-3.76), age less than 20 years (AOR 3.04, 95% CI 1.58-5.85), history of hypertensive disorders of pregnancy (AOR 5.52, 95% CI 1.76-17.33), and no antenatal care (AOR 2.38, 95% CI 1.19-4.75) were found to be the determinants of preeclampsia. We found that living in a rural areas, previous history of preeclampsia, no antenatal care, and < 20 years of age were significantly associated with preeclampsia. In addition to previous preeclampsia, younger and rural resident pregnant women should be given attention in preeclampsia screening and prevention.
摘要：
先兆子痫和子痫是孕产妇死亡率和发病率的第二主要原因。它还导致高围产期死亡率和发病率。由于子痫先于先兆子痫，并显示疾病的进展，它们具有相同的发病机制和决定因素。这项研究的目的是确定先兆子痫的决定因素，因为它对预防和/或相关后果至关重要。一项无与伦比的病例对照研究于2023年9月1日至30日在HiwotFana综合专业大学医院对2020年6月1日至2023年8月31日分娩的妇女进行。患有先兆子痫的妇女被认为是病例，而那些没有控制的人。使用EPIInfo版本7进行病例对照研究，使用以下假设计算样本量：95％置信区间，80%的功率，病例与对照的比例为1:2,5%无缓解率为305.数据是使用谷歌表格收集的，并使用SPSS26版进行了分析。在多变量逻辑回归中p值<0.05的变量被认为具有统计学意义，他们的关联使用95%置信区间的比值比进行解释.共有300名妇女（100例和200名对照），平均年龄为24.4岁。农村住宅（AOR2.04，95%CI1.10-3.76），年龄小于20岁（AOR3.04，95%CI1.58-5.85），妊娠期高血压疾病的病史（AOR5.52，95％CI1.76-17.33），未发现产前护理(AOR2.38,95%CI1.19-4.75)是先兆子痫的决定因素。我们发现生活在农村地区，以前的先兆子痫病史，没有产前护理，<20岁与子痫前期显著相关。除了以前的先兆子痫，在子痫前期筛查和预防中应注意年轻和农村居民孕妇。
