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Abstract：
OBJECTIVE: Orofacial clefts (OFCs) are some of the most common congenital anomalies worldwide. The aim of this case-control study was to evaluate the association of OFCs with selected maternal characteristics.
METHODS: Data on isolated non-syndromic cases of OFCs were extracted from the population-based registry of congenital anomalies of Tuscany. A sample of live-born infants without any congenital anomaly was used as the control group. We investigated the association with sex and some maternal characteristics: age, body mass index, smoking, and education. Adjusted odds ratios (OR) were calculated using a logistic regression model. Analyses were performed for the total OFCs and separately for cleft lip (CL) and cleft palate (CP).
RESULTS: Data on 219 cases and 37,988 controls were analyzed. A higher proportion of males (57.9%) was observed, particularly for CL. A decreasing trend among the maternal age classes was observed (OR:0.81 (95%CI 0.70-0.94)). Underweight mothers had a higher prevalence of OFCs, in particular for CL (OR:1.88 (95%CI 1.08-3.26)).
CONCLUSIONS: We found an association of OFCs with lower maternal age. The association with maternal age remains controversial and further epidemiological evidence is needed through multicenter studies. We observed that CL was more common in underweight mothers, suggesting actions of primary prevention.
METHODS: Data on isolated non-syndromic cases of OFCs were extracted from the population-based registry of congenital anomalies of Tuscany. A sample of live-born infants without any congenital anomaly was used as the control group. We investigated the association with sex and some maternal characteristics: age, body mass index, smoking, and education. Adjusted odds ratios (OR) were calculated using a logistic regression model. Analyses were performed for the total OFCs and separately for cleft lip (CL) and cleft palate (CP).
RESULTS: Data on 219 cases and 37,988 controls were analyzed. A higher proportion of males (57.9%) was observed, particularly for CL. A decreasing trend among the maternal age classes was observed (OR:0.81 (95%CI 0.70-0.94)). Underweight mothers had a higher prevalence of OFCs, in particular for CL (OR:1.88 (95%CI 1.08-3.26)).
CONCLUSIONS: We found an association of OFCs with lower maternal age. The association with maternal age remains controversial and further epidemiological evidence is needed through multicenter studies. We observed that CL was more common in underweight mothers, suggesting actions of primary prevention.
摘要：
目的：面部裂痕（OFC）是全球最常见的先天性畸形。这项病例对照研究的目的是评估OFC与选定的母体特征的关联。
方法：从基于人群的托斯卡纳先天性异常登记中提取关于孤立的非综合征性OFC病例的数据。没有任何先天性异常的活产婴儿样本被用作对照组。我们调查了与性别和一些母亲特征的关系：年龄，身体质量指数,吸烟,和教育。使用逻辑回归模型计算调整后的比值比(OR)。对总OFC进行分析，并分别对唇裂（CL）和left裂（CP）进行分析。
结果：分析了219例病例和37,988例对照的数据。观察到男性比例较高（57.9％），特别是CL。观察到产妇年龄段呈下降趋势（OR：0.81（95CI0.70-0.94））。体重过轻的母亲的OFC患病率较高，特别是对于CL（OR：1.88（95CI1.08-3.26））。
结论：我们发现OFC与低母亲年龄有关。与产妇年龄的关系仍然存在争议，需要通过多中心研究进一步的流行病学证据。我们观察到CL在体重不足的母亲中更常见，建议采取一级预防行动。
方法：从基于人群的托斯卡纳先天性异常登记中提取关于孤立的非综合征性OFC病例的数据。没有任何先天性异常的活产婴儿样本被用作对照组。我们调查了与性别和一些母亲特征的关系：年龄，身体质量指数,吸烟,和教育。使用逻辑回归模型计算调整后的比值比(OR)。对总OFC进行分析，并分别对唇裂（CL）和left裂（CP）进行分析。
结果：分析了219例病例和37,988例对照的数据。观察到男性比例较高（57.9％），特别是CL。观察到产妇年龄段呈下降趋势（OR：0.81（95CI0.70-0.94））。体重过轻的母亲的OFC患病率较高，特别是对于CL（OR：1.88（95CI1.08-3.26））。
结论：我们发现OFC与低母亲年龄有关。与产妇年龄的关系仍然存在争议，需要通过多中心研究进一步的流行病学证据。我们观察到CL在体重不足的母亲中更常见，建议采取一级预防行动。
