PDF(Pubmed)
Abstract：
UNASSIGNED: Early identification of new residual risk factors for coronary heart disease (CHD) is warranted. In this study, we aim to investigate the association between the serine concentration, an important amino acid in one-carbon metabolism, and CHD in Chinese hospitalized patients.
UNASSIGNED: This case-control study included 428 case-control pairs comprising patients with CHD with a maximum coronary artery stenosis degree of >70% and controls with stenosis of <30%. The individuals were matched by age, sex, and date of coronary angiography at Peking University First Hospital from January 1, 2016, to December 31, 2019. Conditional logistic regression was used to investigate the associations between the serine concentration and CHD.
UNASSIGNED: Patients with CHD were aged 63.48 ± 10.38 years, and 43.73% were male. Compared with controls, patients with CHD had a slightly lower serine concentration (13.35 ± 4.20 vs 13.77 ± 4.08 μg/mL), but the difference was not significant. In the multivariable conditional logistic regression analysis, for every 1 μg/mL increase in serine concentration, the odds of CHD decreased by 6% (95% confidence interval [CI] 0.90-0.99; P = 0.010). Patients with a serine concentration of ≥13.41 μg/mL had a lower CHD risk than those with a serine concentration of <13.41 μg/mL (odds ratio [OR] 0.57, 95% CI 0.39-0.84; P = 0.004). Subgroup analyses showed that sex interacted with the relationship between serine concentration and CHD (P interaction = 0.039), which was more significant in males (OR 0.93, 95% CI 0.87-0.98; P = 0.013) than in females.
UNASSIGNED: This study observed an inverse association between the serine concentration and CHD prevalence in Chinese hospitalized patients, which revealed that serine might play a protective role in CHD.
UNASSIGNED: This case-control study included 428 case-control pairs comprising patients with CHD with a maximum coronary artery stenosis degree of >70% and controls with stenosis of <30%. The individuals were matched by age, sex, and date of coronary angiography at Peking University First Hospital from January 1, 2016, to December 31, 2019. Conditional logistic regression was used to investigate the associations between the serine concentration and CHD.
UNASSIGNED: Patients with CHD were aged 63.48 ± 10.38 years, and 43.73% were male. Compared with controls, patients with CHD had a slightly lower serine concentration (13.35 ± 4.20 vs 13.77 ± 4.08 μg/mL), but the difference was not significant. In the multivariable conditional logistic regression analysis, for every 1 μg/mL increase in serine concentration, the odds of CHD decreased by 6% (95% confidence interval [CI] 0.90-0.99; P = 0.010). Patients with a serine concentration of ≥13.41 μg/mL had a lower CHD risk than those with a serine concentration of <13.41 μg/mL (odds ratio [OR] 0.57, 95% CI 0.39-0.84; P = 0.004). Subgroup analyses showed that sex interacted with the relationship between serine concentration and CHD (P interaction = 0.039), which was more significant in males (OR 0.93, 95% CI 0.87-0.98; P = 0.013) than in females.
UNASSIGNED: This study observed an inverse association between the serine concentration and CHD prevalence in Chinese hospitalized patients, which revealed that serine might play a protective role in CHD.
摘要：
■早期发现冠心病（CHD）新的残余危险因素是必要的。在这项研究中,我们的目的是研究丝氨酸浓度之间的关联，一碳代谢中的重要氨基酸,中国住院患者的冠心病。
■这项病例对照研究包括428对病例对照，包括最大冠状动脉狭窄程度>70％的冠心病患者和狭窄<30％的对照组。这些人的年龄相匹配，性别,2016年1月1日至2019年12月31日在北京大学第一医院行冠状动脉造影。使用条件逻辑回归来研究丝氨酸浓度与CHD之间的关联。
■冠心病患者年龄为63.48±10.38岁，43.73%为男性。与对照组相比，冠心病患者的丝氨酸浓度略低（13.35±4.20vs13.77±4.08μg/mL），但差异不显著。在多变量条件Logistic回归分析中，丝氨酸浓度每增加1μg/mL，冠心病的几率降低了6%(95%置信区间[CI]0.90-0.99;P=0.010).丝氨酸浓度≥13.41μg/mL的患者比丝氨酸浓度<13.41μg/mL的患者具有更低的CHD风险(比值比[OR]0.57,95%CI0.39-0.84;P=0.004)。亚组分析表明，性别与丝氨酸浓度和冠心病之间的关系相互作用（P交互作用=0.039），男性比女性更显著(OR0.93,95%CI0.87-0.98;P=0.013)。
■本研究观察到中国住院患者的丝氨酸浓度与冠心病患病率呈负相关，这表明丝氨酸可能在CHD中起保护作用。
■这项病例对照研究包括428对病例对照，包括最大冠状动脉狭窄程度>70％的冠心病患者和狭窄<30％的对照组。这些人的年龄相匹配，性别,2016年1月1日至2019年12月31日在北京大学第一医院行冠状动脉造影。使用条件逻辑回归来研究丝氨酸浓度与CHD之间的关联。
■冠心病患者年龄为63.48±10.38岁，43.73%为男性。与对照组相比，冠心病患者的丝氨酸浓度略低（13.35±4.20vs13.77±4.08μg/mL），但差异不显著。在多变量条件Logistic回归分析中，丝氨酸浓度每增加1μg/mL，冠心病的几率降低了6%(95%置信区间[CI]0.90-0.99;P=0.010).丝氨酸浓度≥13.41μg/mL的患者比丝氨酸浓度<13.41μg/mL的患者具有更低的CHD风险(比值比[OR]0.57,95%CI0.39-0.84;P=0.004)。亚组分析表明，性别与丝氨酸浓度和冠心病之间的关系相互作用（P交互作用=0.039），男性比女性更显著(OR0.93,95%CI0.87-0.98;P=0.013)。
■本研究观察到中国住院患者的丝氨酸浓度与冠心病患病率呈负相关，这表明丝氨酸可能在CHD中起保护作用。
