BACKGROUND: Rheumatology in Germany is facing major challenges. The need for rheumatological care is increasing and can no longer be met in some regions for capacity reasons. Too many people with an inflammatory rheumatic disease (IRD) have to forego appropriate care or receive it too late. The 4th new edition of the memorandum of the German Society for Rheumatology and Clinical Immunology (DGRh) provides information on rheumatological care in Germany. It was produced under the leadership of the DGRh together with the Professional Association of German Rheumatologists (BDRh), the Association of Acute Rheumatology Clinics (VRA), the German Rheumatism League (DRL) and the German Rheumatism Research Center (DRFZ).
METHODS: The memorandum describes the current state and development of the following areas: number of people with IRD, outpatient, inpatient and rehabilitative care structures, number of specialists in rheumatology, education and training, quality of care, health economic aspects and digital care concepts. Proposals for health policy measures to safeguard rheumatological care are presented.
RESULTS: Prevalence: approximately 1.8 million adults in Germany have an IRD. The prevalence is increasing, due to changes in the demographic structure of the population, improved diagnostics, treatment and longer survival. Care structures: outpatient specialist care (ASV) for rheumatic diseases is developing as a cross-sectoral care model for hospital outpatient clinics and rheumatology practices. Hospitals have been able to be certified as rheumatology centers since 2020, which enables structural developments. Specialists in rheumatology: as of 31 December 2023, there were 1164 specialists in rheumatology working in Germany. This included 715 physicians accredited to work in practices for national health assurance patients, 39% of whom were employees. In hospitals, 39% of doctors worked part-time. At least 2 rheumatology specialists per 100,000 adults are needed, i.e. around 1400, in order to provide adequate care. This means that there is a shortage of around 700 rheumatology specialists in the outpatient sector alone. Of all working specialists, 30% are currently aged 60 years old and over. Medical training: only 10 out of 38 (26%) state universities have an independent chair in rheumatology. In addition, 11 rheumatology departments are subordinate to a nonrheumatology chair. In the rheumatology-integration into student training (RISA) III study, only 16 out of 36 faculties fulfilled the recommended minimum number of compulsory hours of student rheumatology teaching. Continuing education in rheumatology: the annual postgraduate training qualifications do not cover the demand for rheumatology specialists, which is additionally increasing due to intensified workload, reduced capacities through retirement, and part-time work. Quality of care: since the introduction of highly effective medication patients with IRD have a much better chance of achieving remission of their disease. With early initiation of targeted therapy, the lives of many patients are hardly restricted at all: however, waiting times for a first rheumatological visit often last more than 3 months. Quality target is a first consultation within the first 6 weeks after the onset of symptoms. Models for early consultation, delegation of medical services, structured patient training and digital care concepts have been positively evaluated but are not covered financially.
RESULTS: the total annual costs for inflammatory joint diseases alone amount to around 3 billion euros. The direct costs have significantly risen since the introduction of biologics, while the indirect costs for sick leave, disability and hospitalization have fallen.
CONCLUSIONS: The core demands of this memorandum are a significant and sustainable increase in the number of further training positions in the outpatient and inpatient sector, the creation of chairs or at least independent departments for rheumatology at all universities and the further implementation of new and cross-sectoral forms of care. This will ensure modern needs-based rheumatological care for all patients in the future.
UNASSIGNED: HINTERGRUND: Die Rheumatologie in Deutschland steht vor großen Herausforderungen: der Bedarf an rheumatologischer Versorgung steigt und kann aus Kapazitätsgründen bereits jetzt in einigen Regionen nicht mehr gedeckt werden. Zu viele Menschen mit einer entzündlich-rheumatischen Erkrankung (ERE) müssen auf eine angemessene Versorgung verzichten oder erhalten diese zu spät. Die 4. Neuauflage des Memorandums der Deutschen Gesellschaft für Rheumatologie und Klinische Immunologie e. V. (DGRh) informiert über die rheumatologische Versorgung in Deutschland. Es wurde unter Führung der DGRh mit dem Berufsverband Deutscher Rheumatologen (BDRh), dem Verband Rheumatologischer Akutkliniken (VRA), der Deutschen Rheuma-Liga (DRL) und dem Deutschen Rheuma-Forschungszentrum (DRFZ) erstellt.
METHODS: Das Memorandum beschreibt den aktuellen Stand und die Entwicklung folgender Bereiche: Anzahl der Personen mit ERE, ambulante, stationäre und rehabilitative Versorgungsstrukturen, Anzahl an Fachärzt:innen für Rheumatologie, Aus- und Weiterbildung, Versorgungsqualität, gesundheitsökonomische Aspekte und digitale Versorgungskonzepte. Vorschläge für gesundheitspolitische Maßnahmen zur Sicherung der rheumatologischen Versorgung werden dargestellt.
UNASSIGNED: Prävalenz: Etwa 1,8 Mio. Erwachsene in Deutschland haben eine ERE. Die Prävalenz steigt aus verschiedenen Gründen: Veränderungen der Altersstruktur der Bevölkerung, verbesserte Diagnostik und Therapie mit längerem Überleben. Versorgungsstrukturen: Neben der regulären kassenärztlichen Versorgung hat sich die ambulante spezialfachärztliche Versorgung (ASV) als sektorenübergreifendes Versorgungsmodell etabliert. Krankenhäuser können sich seit 2020 als rheumatologische Zentren zertifizieren lassen, was strukturelle Weiterentwicklungen ermöglicht. Fachärzt:innen (FÄ) für Rheumatologie: Zum 31.12.2023 waren in Deutschland 1164 FÄ für Rheumatologie berufstätig. Vertragsärztlich waren dies 715 FÄ, davon 39 % angestellt. In Krankenhäusern waren 39 % der FÄ in Teilzeit tätig. Für eine bedarfsgerechte ambulante Versorgung benötigen wir mindestens 2 FÄ für Rheumatologie pro 100.000 Erwachsene, das sind rund 1400. Es fehlen also allein im ambulanten Bereich zum jetzigen Zeitpunkt etwa 700 FÄ für Rheumatologie. Von allen berufstätigen FÄ sind 30 % derzeit 60 Jahre und älter. Ärztliche Ausbildung: Nur 10 von 38 (26 %) staatlichen Universitäten verfügen über einen eigenständigen rheumatologischen Lehrstuhl. Darüber hinaus sind 11 rheumatologisch geführte Abteilungen einem nicht-rheumatologischen Lehrstuhl untergeordnet. Nur 16 von 36 Fakultäten erfüllten in der RISA III-Studie die empfohlene Mindestzahl an Pflichtstunden studentischer rheumatologischer Lehre. Rheumatologische Weiterbildung: Die jährlichen Weiterbildungsabschlüsse für Rheumatologie decken nicht den Bedarf an rheumatologischen FÄ, der durch steigende Arbeitsbelastung, reduzierte Kapazitäten durch Pensionierung und zunehmende Teilzeittätigkeit noch zunimmt. Versorgungsqualität: Rheuma-Betroffene haben seit Einführung hochwirksamer Medikamente eine deutlich bessere Aussicht auf eine Remission ihrer Erkrankung. Bei frühzeitiger adäquater Therapie ist die Lebensführung vieler Betroffener kaum noch eingeschränkt. Die Wartezeit auf eine rheumatologische Erstvorstellung beträgt aber oft mehr als 3 Monate. Qualitätsziel ist eine Vorstellung innerhalb der ersten 6 Wochen nach Symptombeginn. Frühsprechstunden, Delegation ärztlicher Leistungen, strukturierte Patientenschulungen und digitale Versorgungskonzepte wurden positiv evaluiert, sind aber nicht finanziell gedeckt. Kosten: Die jährlichen Gesamtkosten allein für entzündliche Gelenkerkrankungen belaufen sich auf etwa 3 Mrd. €. Die direkten Kosten sind seit Einführung der Biologika deutlich gestiegen, während indirekte Kosten für Krankschreibung, Erwerbsunfähigkeit und stationäre Aufenthalte gesunken sind.
UNASSIGNED: Kernforderungen dieses Memorandums sind: die deutliche und nachhaltige Steigerung der Zahl von Weiterbildungsstellen im ambulanten und stationären Bereich, die Schaffung von Lehrstühlen oder mindestens eigenständigen Abteilungen für Rheumatologie an allen Universitäten sowie die weitere Umsetzung neuer und sektorenübergreifender Versorgungsformen. Dies stellt eine bedarfsgerechte, moderne rheumatologische Versorgung für alle Betroffenen auch in Zukunft sicher.

Climate change has significant consequences for children\'s respiratory health. Rising temperatures and extreme weather events increase children\'s exposure to allergens, mould, and air pollutants. Children are particularly vulnerable to these airborne particles due to their higher ventilation per unit of body weight, more frequent mouth breathing, and outdoor activities. Children with asthma and cystic fibrosis are at particularly high risk, with increased risks of exacerbation, but the effects of climate change could also be observed in the general population, with a risk of impaired lung development and growth. Mitigation measures, including reducing greenhouse gas emissions by healthcare professionals and healthcare systems, and adaptation measures, such as limiting outdoor activities during pollution peaks, are essential to preserve children\'s respiratory health. The mobilisation of society as a whole, including paediatricians, is crucial to limit the impact of climate change on children\'s respiratory health.

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OBJECTIVE: To establish a next-generation reference interval (RI) for total IgE (tIgE) and evaluate its usefulness.
METHODS: A new allergen-specific IgE (sIgE)-based tIgE RI, including a continuous RI in children, was established using the NHANES 2005-2006 project. The usefulness of the RI was evaluated by sensitivity (Sen), specificity (Spec), positive predictive value (PPV), negative predictive value (NPV), κ coefficient and consistency.
RESULTS: The new tIgE RI showed better performance in identifying allergic sensitization (Sen 0.53, Spec 0.90, PPV 0.83, NPV 0.68, κ 0.44, consistency 0.72) than allergic diseases (Sen 0.37, Spec 0.75, PPV 0.55, NPV 0.60, κ 0.13, consistency 0.59). The 2014 U.S. tIgE RI was more effective in identifying allergic diseases (consistency 0.63 vs. 0.54, P<0.001) but less accurate in identifying allergic sensitization (consistency 0.59 vs. 0.67, P<0.001) in children than in adults. The new RI improved the accuracy of identifying allergic sensitization in children to a level similar to that in adults (consistency 0.72 vs 0.73, P=0.37) and maintained its advantage in identifying allergic diseases in children (consistency 0.64 vs 0.55, P<0.001).
CONCLUSIONS: The established next-generation tIgE RI is useful for identifying allergic sensitization, especially in children.

The ability of organophosphate pesticides to disturb immune function has been demonstrated by in vivo and in vitro studies, but evidence of such effects on humans remains scarce. To assess the association between organophosphate pesticides exposure and cytokine levels in Mexican flower workers, a cross-sectional study was carried out. A questionnaire was provided to 121 male flower workers, and urine and blood samples were collected. Using gas chromatography, urinary concentrations of dialkylphosphate metabolites were determined. The serum cytokine levels, IL-4, IL-5, IL-6, IL-8, and IL-10, were measured using multiplex analysis, and levels of INF-γ and TNF-α by ELISA. We found that a higher dialkylphosphate concentration decreased the pro-inflammatory cytokines INF-γ (β = -0.63; 95 % CI: -1.22, -0.05), TNF-α (β= -1.18; 95 % CI: -2.38, 0.02), and IL-6 (β= -0.59; 95 % CI: -1.29, 0.12), and increased IL-10 (β=0.56; 95 % CI: 0.02, 1.09), the main anti-inflammatory cytokine, suggesting an imbalance of the immune response in flower workers.

Hypereosinophilic syndrome (HES) encompasses a heterogeneous and complex group of different subtypes within the wider group of hypereosinophilic disorders. Despite increasing research interest, several unmet needs in terms of disease identification, pathobiology, phenotyping, and personalized treatment remain to be addressed. Also, the prospective burden of non-malignant HES and, more in general, HE disorders is currently unknown. On a practical note, shortening the diagnostic delay and the time to an appropriate treatment approach probably represents the most urgent issue, even in light of the great impact of HES on the quality of life of affected patients. The present document represents the first action that the Italian Society of Allergy, Asthma, and Clinical Immunology (SIAAIC) has finalized within a wider project aiming to establish a collaborative national network on HES (InHES-Italian Network on HES) for patients and physicians. The first step of the project could not but focus on defining a common language as well as sharing with all of the medical community an update on the most recent advances in the field. In fact, the existing literature has been carefully reviewed in order to critically integrate the different views on the topic and derive practical recommendations on disease identification and treatment approaches.

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OBJECTIVE: To investigate dermatology and allergology nurses\' experiences of relocation from an outpatient clinic to a newly established COVID-19 infectious disease ward.
METHODS: A phenomenological-hermeneutical approach was applied.
METHODS: Three focus groups with nurses were conducted from June to August 2020. Data were analysed in accordance with Ricoeur\'s theory of interpretation.
RESULTS: The relocation represented a challenging period that involved uncertainty and evoked feelings of excitement and dedication towards the nursing profession. Nurses felt obligated to help; however, they also experienced that they did not have a say in the relocation. The placement on the infectious disease ward was characterized by adaptations in three areas: unfamiliar working environment, unfamiliar team competencies and inadequate nursing training. E-learning training was experienced as insufficient, as it did not enhance the nurses\' specific competencies or confidence in caring for patients with COVID-19.
CONCLUSIONS: The relocation of nurses from an outpatient clinic to a new COVID-19 infectious disease ward created a dilemma between nurses\' sense of duty and their right to self-determination. A prompt relocation into a newly established unfamiliar field caused frustrations because there were no unspoken rules to rely on. Managers should take nurses\' experiences and perceptions under careful consideration and strive for more involvement in future scenarios.
UNASSIGNED: No patient or public contribution.