%0 Journal Article
%T Next-generation reference interval for total IgE in the United States: A retrospective real-world analysis.
%A Fang H
%A Li J
%A Wen X
%A Ren L
%A Liu E
%J Clin Chim Acta
%V 563
%N 0
%D 2024 Sep 15
%M 39074651
%F 6.314
%R 10.1016/j.cca.2024.119895
%X <B>OBJECTIVE: </B>To establish a next-generation reference interval (RI) for total IgE (tIgE) and evaluate its usefulness.<BR><B>METHODS: </B>A new allergen-specific IgE (sIgE)-based tIgE RI, including a continuous RI in children, was established using the NHANES 2005-2006 project. The usefulness of the RI was evaluated by sensitivity (Sen), specificity (Spec), positive predictive value (PPV), negative predictive value (NPV), κ coefficient and consistency.<BR><B>RESULTS: </B>The new tIgE RI showed better performance in identifying allergic sensitization (Sen 0.53, Spec 0.90, PPV 0.83, NPV 0.68, κ 0.44, consistency 0.72) than allergic diseases (Sen 0.37, Spec 0.75, PPV 0.55, NPV 0.60, κ 0.13, consistency 0.59). The 2014 U.S. tIgE RI was more effective in identifying allergic diseases (consistency 0.63 vs. 0.54, P<0.001) but less accurate in identifying allergic sensitization (consistency 0.59 vs. 0.67, P<0.001) in children than in adults. The new RI improved the accuracy of identifying allergic sensitization in children to a level similar to that in adults (consistency 0.72 vs 0.73, P=0.37) and maintained its advantage in identifying allergic diseases in children (consistency 0.64 vs 0.55, P<0.001).<BR><B>CONCLUSIONS: </B>The established next-generation tIgE RI is useful for identifying allergic sensitization, especially in children.