■青光眼是全球范围内不可逆性失明的主要原因,Molteno和Ahmed青光眼植入物,在不同的机制上运作,已用于治疗复杂的青光眼,取得了不同的成功。
■评估复杂性青光眼患者Molteno青光眼植入物(MGI)与Ahmed青光眼阀(AGV)的安全性和有效性。
■我们全面搜索了PubMed,谷歌学者,CochraneLibraryandScienceDirect)从成立到2023年7月,并对MGI患者和AGV患者的复杂性青光眼患者进行了比较研究。主要结果是不同时间间隔的眼内压降低。次要结果包括手术成功率,高血压期,抗青光眼药物(AGM)和总并发症。
■在此荟萃分析中,纳入四项研究的患者群体为257名难治性患者,新生血管性或晚期未控制的青光眼。术后眼压降低在两组之间没有显着差异(MD:-1.34,95%CI[-2.78,0.09])。从次要结果来看,手术成功率(RR:0.88,95%CI[0.51,1.53]),高血压期(RR:0.74,95%CI[0.39,1.40])不显著.术后抗青光眼药物(MD:-0.07,95%CI[-0.79,-0.65]和总并发症(RR:1.36,95%CI[1.07,1.72])显着。
■MGI和AGV患者的主要结局没有显著差异。从次要结果来看,AGV与减少抗青光眼药物的使用有关,并显着降低了并发症的数量。
■https://www.crd.约克。AC.uk/prospro/display_record.php?RecordID=475539,标识符CRD42023475539。
UNASSIGNED: Glaucoma is a leading cause of irreversible blindness globally and for decades, Molteno and Ahmed glaucoma implants, operating on different mechanisms, have been used to treat complicated glaucoma with varying success.
UNASSIGNED: To assess the safety and efficacy of the Molteno glaucoma implant (MGI) versus the Ahmed glaucoma valve (AGV) in patients with complicated glaucoma.
UNASSIGNED: We comprehensively searched PubMed, Google Scholar, Cochrane Library and Science Direct) from inception till July 2023 and studies comparing patients with MGI and those with AGV in patients with complicated glaucoma. The primary outcome was intra-ocular pressure reduction at different time intervals. Secondary outcomes included surgical success rate, hypertensive phase, anti-glaucoma medication (AGM) and total complications.
UNASSIGNED: In this meta-analysis, four studies were included with a patient population of 257 with refractory, neovascular or advanced uncontrolled glaucoma. Postoperative intra-ocular pressure reduction did not show significant difference between the two groups (MD: -1.34, 95% CI [-2.78, 0.09]). From the secondary outcomes, surgical success rate (RR: 0.88, 95% CI [0.51,1.53]), hypertensive phase (RR: 0.74, 95% CI [0.39,1.40]) were insignificant. Postoperative anti-glaucoma medication (MD: -0.07, 95% CI [-0.79, -0.65] and total complications (RR:1.36, 95% CI [1.07, 1.72]) were significant.
UNASSIGNED: No significant difference was observed between the patients with MGI and AGV for the primary outcome. From the secondary outcome, AGV was associated with reduced anti-glaucoma medication use and significantly lowered the number of complications.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=475539, identifier CRD42023475539.